DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and Mlh3

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_006515766.1	Gene:	Mlh3 / 217716	MGIID:	1353455	Length:	1443	Species:	Mus musculus

Alignment Length:	962	Identity:	203/962 - (21%)
Similarity:	358/962 - (37%)	Gaps:	278/962 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            |:.:..|...|:.||..:.||...|:||..|||||.||.|.|::..:..| |:|.|||.|:...:
Mouse     2 IRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQ-VQVIDNGLGMAGDD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVEL------- 149
            :|.:..:|.|||.....||.....:|||||||:|:..::..|..:..|:|.:...|::
Mouse    66 VEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKAL 130

  Fly   150 -DHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRIL 213
             .||..:.:.|     |||||.:.|||...||||:.....:  ||.|:.|.::|..|:...:...
Mouse   131 ATHEADLTRPS-----VGTTVTVYNLFYQFPVRRKSMDPRL--EFEKVRQRVEALSLMHPSISFS 188

  Fly   214 CSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADL 278
            ..|..   :.::|||....:::.:....|:|             .|:.|    :||
Mouse   189 LRNDV---SGSMVLQLPKTKDICSRFCQIYG-------------LGKSQ----KLR--------- 224

  Fly   279 ADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSR---------------- 327
                  :|      |....:|:..|:|||..|    .:::.||.|||.|
Mouse   225 ------EI------RFKYKEFEFSGYISSEAH----YNKNMQFLFVNRRLVLRTKLHKLIDFLLR 273

  Fly   328 ----PCDPKN--IAKVMNEVYHRYNVQQQPFIY-LNIITARSDVDVNLTPDKRQLLINNERILLL 385
                .|.|||  .::.||......:..:...|| :|:.....:.||.:.|
Mouse   274 KESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEP--------------- 323

  Fly   386 ALKKSLLDTFGQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRF 450
              .|:|::        ||..:|.::.:.|     |..:|.|:   :....|:|.||:...:....
Mouse   324 --AKTLIE--------FQSWDTVLICIQE-----GVKRFLKQ---EKLFVELSGEDIKEFNEDNG 370

  Fly   451 MDVLTQWRRTGDTKGTAPSVPVKRRCSES-------------EELVTRTLKMQKIHTFLSQESPN 502
            ..:.      |.|..|  .|....:|.:|             |....::..:::|.|..::...|
Mouse   371 FSLF------GTTLQT--HVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQN 427

  Fly   503 EQSSKC-------EAESDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRID 560
            ...|:.       ...:||:.....:|..::.:...|:...|:....|.|........:|.
Mouse   428 PGDSETIRKKTVGSLYTDASDGPCYSKSVESVLQDSNNSAYLEPRVSEEEVAKTSHSGENE---- 488

  Fly   561 CKVLTPIKSRRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFD 625
                   |.::|..|.||....   .|:..::.|.|.....|.||      .:..:|:.|.....
Mouse   489 -------KWKKSFLENKTSGRI---HETSPKMFSSPIQMHHLLEE------READLEMQTISSTV 537

  Fly   626 EEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQ 690
            ..|...:|.|   .:|.:.||:...:            .....|.|.|:|.:...:.|..:.|.:
Mouse   538 NVMAANIPQN---NDIPSQLEKWKDA------------PEVGCQPLPFETTLLRVRGTQRKKERR 587

  Fly   691 REIDKEDFARMEI----IGQFNL---GFI--IVKLEDDLFIVDQHA--TDEKYNFETLQRTTQLE 744
            :   ||..:|..:    .||..|   |||  :|:.|        ||  |:.:::|:...|...:.
Mouse   588 K---KEPSSRGRVNVFSYGQVKLCSTGFITHVVQSE--------HAKSTETEHSFKNYARPGPVS 641

  Fly   745 YQR---------LAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKR 800
            .|.         :..|.:.:||:.                    :..|:         .:|.:||
Mouse   642 AQETFGKRTHHAIETPDSSDLTST--------------------LSKES---------SQPPNKR 677

  Fly   801 W-----EFGKED----IDELIFMLQDAPEGTICRPSRVRAM-----------FASRACRKSVMIG 845
            :     .:|.|:    .|:.:.:.|::     |:.|....:           :.|..|||....|
Mouse   678 FCRTNTGYGTENKPVATDDNLALFQES-----CKESHTDRLLPDASSFPWCRYVSDGCRKIDKRG 737

  Fly   846 T---ALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLINIAMLINSDENDE 894
            :   .:.|..::|   :|:|.:|: :...:|:      ::.::....|.|.|
Mouse   738 SFKQVVRRKLSLR---SQVGSLEK-FKRQYGK------VSSSLDTEKDNNTE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	200/946 (21%)
		HATPase_c	46..>151	CDD:294057	40/112 (36%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	32/165 (19%)
		MutL_C	703..847	CDD:214857	32/186 (17%)
Mlh3	XP_006515766.1	HATPase_MutL-MLH-PMS-like	12..192	CDD:340403	64/187 (34%)
		MutL_Trans_MLH3	206..349	CDD:239568	40/214 (19%)
		MutL_C	1185..1365	CDD:214857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820