Protein Alignment Pms2 and mlh-1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_499796.2
• Gene: mlh-1 / 176783
• WormBaseID: WBGene00003373
• Length: 758
• Species: Caenorhabditis elegans
• Alignment Length: 808
• Identity: 175/808 - (21%)
• Similarity: 295/808 - (36%)
• Gaps: 255/808 - (31%)

  Fly    25 GQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEE 89
            |.|:.:.:|.|:::.:|:|:.....|:|||||||:|||||.:.:.:::.||:.::|||||.|:|.
 Worm     2 GLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNGKGIER 66

  Fly    90 MNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGR 154
            .:...:..::.|||:::|.||:.::|:|||||||:||..::.:.|.::........:........
 Worm    67 EDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCAYQANFLDGKM 131

  Fly   155 IKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHTP 219
            .....|.|...||.:...:||..||.||...|
 Worm   132 TADTKPAAGKNGTCITATDLFYNLPTRRNKMT--------------------------------- 163

  Fly   220 KGAKTIVLQTHGDQEVMAN------------ISAIFGARQAADLVPLKSPFGQGQLTEAELRADL 272
                     |||::..|.|            :|......||.|.    ...|.|...:.....
 Worm   164 ---------THGEEAKMVNDTLLRFAIHRPDVSFALRQNQAGDF----RTKGDGNFRDVVCNL-- 213

  Fly   273 ESGADLADTTSPQISTEDVERLNQADFQLEGFIS----SCRHGAGRSSR-DRQFF--FVNSRP-- 328
             .|.|:|||..| :|.... ||.   |...|.||    |......::.: .|.||  |:|.|.
 Worm   214 -LGRDVADTILP-LSLNST-RLK---FTFTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVR 272

  Fly   329 CDPKNIAK-VMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLL-INNERI---LLLALK 388
            ||   |.| .::||.....:..| |..|::....:.:|||:.|.|..:: :..|.|   :....:
 Worm   273 CD---ILKHPIDEVLGARQLHAQ-FCALHLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIRAYFE 333

  Fly   389 KSLLDTFGQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDV 453
            |.:.:.||     |:..:               .:.|:|...|.::..:    :|.:.:.:.::.
 Worm   334 KVIGEIFG-----FEALD---------------VEKPEEEQPDIENLVM----IPMSQSLKSIEA 374

  Fly   454 LTQWRRTGDTKGTAPSVPV-----KRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESD 513
            :    |..|||....|.|.     |:|....|  |....|.:||..|:::......::   :..|
 Worm   375 I----RKPDTKPEFKSSPSAWKSDKKRVDYME--VRTDAKERKIDEFVTRGGAVGPTT---SNDD 430

  Fly   514 AASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKS---RRSIFE 575
            ......:.|:.:|:.|...          |.|..||     ||...|..:::.:.:   ||
 Worm   431 IFGGSGILKRARTEDSTGG----------EKEPEDL-----NTDFDDVSMVSLVSTADGRR---- 476

  Fly   576 FKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIEL-PTRIEFDEEMEEGLPSNFSSG 639
                                      |:|..|:..|:|...|. .|..||          :|.|.
 Worm   477 --------------------------LNESQDLGEDDDVDFEYGKTHREF----------HFESI 505

  Fly   640 EITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEII 704
            |:                               .:.||..|.:.|.         :|.|.....:
 Worm   506 EV-------------------------------LRKEIIANSSQSL---------REMFKTSTFV 530

  Fly   705 GQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHID 769
            |..|:..::::....|:.:|         |.|:.|  :..||                     |.
 Worm   531 GSINVKQVLIQFGTSLYHLD---------FSTVLR--EFFYQ---------------------IS 563

  Fly   770 VFEKNGF-KFEVDHEAPATKKV-RLLGK 795
            ||....: .:.:|.|.||..:: .|||:
 Worm   564 VFSFGNYGSYRLDEEPPAIIEILELLGE 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	174/807 (22%)
		HATPase_c	46..>151	CDD:294057	39/104 (38%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	41/165 (25%)
		MutL_C	703..847	CDD:214857	19/95 (20%)
mlh-1	NP_499796.2	mutl	2..316	CDD:273155	101/371 (27%)
		Mlh1_C	501..756	CDD:374528	28/163 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820