DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and Mlh1

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_081086.2	Gene:	Mlh1 / 17350	MGIID:	101938	Length:	760	Species:	Mus musculus

Alignment Length:	912	Identity:	183/912 - (20%)
Similarity:	349/912 - (38%)	Gaps:	244/912 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            ::|.|:.:.:..|::|.:|:|:...|.|:||::||.:||.:|.:::.:|:.||:.:::.|||:|:
Mouse     4 VAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQIQDNGTGI 68

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHE 152
            .:.:|:.:..::.|||::.|.||..:.|:|||||||:|:..::.:.|.|:........:.... :
Mouse    69 RKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYS-D 132

  Fly   153 GRIK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSN 216
            |::: ...|||...||.:.:.:||..: :.||...:|..:|:.|:.:::..|.:...|:    |.
Mouse   133 GKLQAPPKPCAGNQGTLITVEDLFYNI-ITRRKALKNPSEEYGKILEVVGRYSIHNSGI----SF 192

  Fly   217 HTPKGAKTIV-LQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLAD 280
            ...|..:|:. ::|..:...:.||.:|||...:.:|:
Mouse   193 SVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELI---------------------------- 229

  Fly   281 TTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRY 345
                ::..||    ....|::.|:||:..:...:..   ...|:|.|..:...:.|.:..||..|
Mouse   230 ----EVGCED----KTLAFKMNGYISNANYSVKKCI---FLLFINHRLVESAALRKAIETVYAAY 283

  Fly   346 NVQQ-QPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSL-LDTFGQTPATFQMQNTT 408
            ..:. .||:||::..:..:||||:.|.|.::...:|..:|..:::.: ....|...:......|.
Mouse   284 LPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLGSNSSRMYFTQTL 348

  Fly   409 IVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVK 473
            :..:..|...:.:                     |||..           .:..|.|:...|
Mouse   349 LPGLAGPSGEAAR---------------------PTTGV-----------ASSSTSGSGDKV--- 378

  Fly   474 RRCSESEELVTRTLKMQKIHTFL---SQESPNE-------QSSKCEAESDAASDVDMAKKDKTQV 528
                .:.::|....:.||:..||   |...|::       :.::.|...:.|:     ::|:..:
Mouse   379 ----YAYQMVRTDSREQKLDAFLQPVSSLGPSQPQDPAPVRGARTEGSPERAT-----REDEEML 434

  Fly   529 SLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQESPAELN 593
            :|...    .|.|.|||..:                     |.|:.|      ..|..:..|..:
Mouse   435 ALPAP----AEAAAESENLE---------------------RESLME------TSDAAQKAAPTS 468

  Fly   594 SQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTS------LEEIASSL 652
            |...|..:..|::|:                  ||.|    |.|..|:|.:      :..:.|.|
Mouse   469 SPGSSRKRHREDSDV------------------EMVE----NASGKEMTAACYPRRRIINLTSVL 511

  Fly   653 KAHEQ-QQRDRRT-RTKLQRLRFKTEINPN-------------QNTSAEAELQREIDKEDFARME 702
            ...|: .:|...| |..|:...|...:||.             ..|....||..:|...|||
Mouse   512 SLQEEISERCHETLREMLRNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA--- 573

  Fly   703 IIGQFNLGFIIVKLEDDLFIVDQHATDE----------------KYNFETLQRTTQLEYQRLAVP 751
                 |.|.:.:.....||.:...|.|.                :|..|.|::..::    ||..
Mouse   574 -----NFGVLRLSEPAPLFDLAMLALDSPESGWTEDDGPKEGLAEYIVEFLKKKAEM----LADY 629

  Fly   752 QNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATK--KVRLLGKPHSKRWEFGKEDIDELIFM 814
            .::|:.....::           |....:|...|..:  .:.:|.......|:..||..:.|
Mouse   630 FSVEIDEEGNLI-----------GLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESL--- 680

  Fly   815 LQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRH 879
                        |:..|||.|  .||..:    |..:|...:.....|...:||     :.|:.|
Mouse   681 ------------SKECAMFYS--IRKQYI----LEESTLSGQQSDMPGSTSKPW-----KWTVEH 722

  Fly   880 LI 881
            :|
Mouse   723 II 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	180/906 (20%)
		HATPase_c	46..>151	CDD:294057	34/104 (33%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	29/143 (20%)
		MutL_C	703..847	CDD:214857	27/161 (17%)
Mlh1	NP_081086.2	mutl	6..315	CDD:273155	88/353 (25%)
		HATPase_c	31..>132	CDD:294057	33/101 (33%)
		MutL_Trans_MLH1	211..335	CDD:239565	31/162 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..375		6/52 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..488		23/145 (16%)
		Interaction with EXO1. /evidence=ECO:0000250\|UniProtKB:P40692	412..654		57/322 (18%)
		Mlh1_C	505..760	CDD:293022	52/269 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820