DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pms2 and Lef1

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001365988.1	Gene:	Lef1 / 16842	MGIID:	96770	Length:	412	Species:	Mus musculus

Alignment Length:	172	Identity:	35/172 - (20%)
Similarity:	55/172 - (31%)	Gaps:	63/172 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 QP-PSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSG-----EITTSLEE---IAS 650
            || ||  .||.:|.::             .|...|..|.|...::|     .:|..:::   ...
Mouse   225 QPYPS--SLSGDTSMS-------------RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTD 274

  Fly   651 SLKAHEQQQRDRRTRTKLQRLRFKTEINP--------NQNTSAEAELQREIDKEDFARMEIIGQF 707
            |...|.:.|.::|...:.:|...|..:|.        ..|..||..|     ||..|..:|:|:
Mouse   275 SDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTL-----KESAAINQILGR- 333

  Fly   708 NLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLA 749
                                     .:..|.|..|.:|..||
Mouse   334 -------------------------RWHALSREEQAKYYELA 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	35/172 (20%)
		HATPase_c	46..>151	CDD:294057
		MutL_Trans_hPMS_2_like	238..381	CDD:239566
		MutL_C	703..847	CDD:214857	8/47 (17%)
Lef1	NP_001365988.1	CTNNB1_binding	1..211	CDD:400583
		CTNNB1-binding	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..191
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..296		5/29 (17%)
		SOX-TCF_HMG-box	296..367	CDD:238684	17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1472
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950