Protein Alignment Pms2 and Mlh1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_320342.5
• Gene: Mlh1 / 1280495
• VectorBaseID: AGAMI1_003300
• Length: 674
• Species: Anopheles gambiae
• Alignment Length: 676
• Identity: 155/676 - (22%)
• Similarity: 291/676 - (43%)
• Gaps: 145/676 - (21%)

  Fly    25 GQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEE 89
            |.|:.:.:..|::|.:|:::...|.|:||::|||:||.||.:.|.:|..||:|:::.|||:|:..
Mosquito     4 GVIRKLDEVVVNRIAAGEIIQRPANALKEMIENSLDAKATSITITVKAGGLRSLQIQDNGTGIRR 68

  Fly    90 MNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGR 154
            .:|..:..::.|||::.|.||..:.|:|||||||:|:..::.:.|.|:.|......|...: :|:
Mosquito    69 EDLGIVCERFTTSKLQSFDDLSSISTYGFRGEALASISHVAHLTIVTKTKHEKCAYKACYE-DGK 132

  Fly   155 IK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAY-------CLVTKGVR 211
            :| ...|.|...||.:.:..||..:|:|::.. :...:||.::..::..|       |.:.|
Mosquito   133 LKGDIKPIAGNQGTQITVDELFYNVPMRKQAL-KTPNEEFQRISDVVSRYAVHNPHACFILK--- 193

  Fly   212 ILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGA 276
                    |..:|..::|.....|..||.||:||.....|||:            |||
Mosquito   194 --------KFGETATIRTQAKTTVAHNIGAIYGAGIGKALVPI------------ELR------- 231

  Fly   277 DLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEV 341
                        ::|.:|.     :||::::.....   .:.....|:|.|..:...:.|.::.:
Mosquito   232 ------------DEVMQLT-----VEGYVTNVNFSL---KKGISLMFINHRAVECSALKKAIDAI 276

  Fly   342 YHRYNVQ-QQPFIYLNIITARSDVDVNLTPDKRQL-LINNERI---LLLALKKSLLDTFGQTPAT 401
            |..|..: ..||:||::.....:||||:.|.|.:: .::.|.|   :.|.::::||.  |....:
Mosquito   277 YAVYLPKGSAPFVYLSLELNPQNVDVNVHPTKHEVHFLHEEEIVEKVKLLVERALLG--GNAARS 339

  Fly   402 FQMQNTTIVSMLEPKTNSGKTKFPKESSK--------DDQHEEVSEEDVPTTSTQRFMDVLTQWR 458
            :       ...|.|    |.|: |.:|||        .|:...:..:.|.|:.:::.::......
Mosquito   340 Y-------TQALLP----GATQ-PLDSSKVNESMVGGGDEKPRLDYKFVRTSHSEQKLEKFFNIS 392

  Fly   459 RTGDTKGTAPSVPVKRR--------------CSESEELVTRTLKMQKIHTFLSQ-ESPNEQS-SK 507
            .:|.........|:|..              .|..:::|.|..::..|||...| ||..::: .|
Mosquito   393 GSGAGSSAGGGDPIKEEPQDEVVEPKLTQPSPSRKKKVVKRETRLHSIHTLRQQVESDGDENLRK 457

  Fly   508 CEAESDAASDVDMAKKDKTQVSLDNSFL--NLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSR 570
            ...|......:|   :::..:..|....  .::.:|:|.....||....|..|:  .:..|:..:
Mosquito   458 IFRELTYVGTID---REQVLIQYDTKMYLSKVQPIAEELFYQLLLFNFGNFERL--TLSEPLDLK 517

  Fly   571 RSIFEFKTD-AMALDKQESPAE---------LNSQPPSFTQLSEETDIASDEDDHIE-------- 617
            |.:.....| |....:::.||:         |.|:.|   .|.|..:::..||..:|
Mosquito   518 RLVHAGLDDPASGYTEEDGPADELADVIVQKLVSKAP---VLREYYNLSIREDGCLESLPKLLDN 579

  Fly   618 --------------LPTRIEFDEEME 629
                          |.|.:|::||.|
Mosquito   580 YIPSLVFLPMYVIRLATDVEWEEEQE 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	96/360 (27%)
		mutL	33..880	CDD:234630	153/668 (23%)
Mlh1	XP_320342.5	None