Protein Alignment Pms2 and Pms2

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_061519472.1
• Gene: Pms2 / 1269980
• VectorBaseID: AGAMI1_010973
• Length: 934
• Species: Anopheles gambiae
• Alignment Length: 961
• Identity: 475/961 - (49%)
• Similarity: 624/961 - (64%)
• Gaps: 128/961 - (13%)

  Fly    11 EEEPDVPPPTTALSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGL 75
            |.|..:.|.|.|.|.:|.||.|:|||:||||||||:||:|||||||||:||||||:|:||:..|.
Mosquito     4 ELETPMLPATNAESSKINAIDKETVHRICSGQVVLNLAIAVKELVENSLDAGATLIEVKLRGCGA 68

  Fly    76 QSVEVSDNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKS 140
            :.||||||||||||.|.||:||||||||::||.||..:|||||||||||||||||||:|.|||.:
Mosquito    69 ELVEVSDNGSGVEEKNFEGLTAKYHTSKLKEFTDLESIETFGFRGEALSSLCALSDMIITTRHST 133

  Fly   141 TDVGVKVELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCL 205
            .....|:.|:|||||:.|:|||..|||||.|.|||:|||||:::|.||||:||.:||||||||||
Mosquito   134 APHATKLTLNHEGRIQTRAPCAHPVGTTVSLTNLFATLPVRKKEFQRNIKREFQRMCQILQAYCL 198

  Fly   206 VTKGVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPF-GQGQLTEAELR 269
            |:.||||:|:|||.||.|::::.|.|...|:.|::|:||.:|.|:|:.|.... |.|::
Mosquito   199 VSVGVRIICTNHTAKGGKSVIMSTQGSSRVLDNVTALFGTKQTAELMQLVPCIGGNGKI------ 257

  Fly   270 ADLESGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNI 334
            .|||: :|..|  |..::.|:|:..|.:.:::||:||||.||:|||::||||:|:|||||:||.|
Mosquito   258 QDLEA-SDFDD--SMALTQEEVDNFNLSRYKIEGYISSCAHGSGRSTKDRQFYFINSRPCEPKQI 319

  Fly   335 AKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTP 399
            :|::|:.||||||.||||::||::..||:|||||||||||:|:|||:||:||::||:..||...|
Mosquito   320 SKLINDAYHRYNVHQQPFVFLNLMLDRSEVDVNLTPDKRQVLVNNEKILMLAIRKSIKKTFQTVP 384

  Fly   400 ATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHE--EVSEEDVPTTSTQRFM--DVLTQWR-- 458
            ::|.|||..:      ...|........|.|||:.|  |..|:.:.::|:.:..  |:|..::
Mosquito   385 SSFTMQNQNL------SDTSRLLNISLPSDKDDEEENGEEREDFLNSSSSDKCTAGDLLFTFQPP 443

  Fly   459 --RTGDTKGTAPSVPVKR--RCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVD 519
              .:|...||......||  .||..         |||:..||:....:::|  |   :|:.:|.:
Mosquito   444 KMASGFGGGTGGGQKRKRSSNCSGG---------MQKMIDFLNTTKASQKS--C---NDSMTDEE 494

  Fly   520 MAKKDKTQVSLDNSFLNLKELAKESEAYDL--LTKPQNTPRIDCKVLTPIKSRRSI--------- 573
                       |.:..:.|:...|...|||  |.:|.:..|.:..|...:|..|.|
Mosquito   495 -----------DATMRSSKQAKNEENPYDLTILKEPSSEERDEHVVQESVKVIRCINGKEQDPPF 548

  Fly   574 -FEFKTDAMAL------DKQESPAEL-----------NSQPPSFTQLSEETDIASDEDDHIEL-- 618
             .|.:.|.:::      ..|||..||           :|..||.:|.|....|    ||.:|:
Mosquito   549 QEERQRDELSMKANAGTSSQESVTELVSFLSCKTEASDSSSPSLSQTSASRAI----DDGMEIIP 609

  Fly   619 ---------------PTRIE-----------------FDEEM--EEGLPSNF---SSGEITTSLE 646
                           |.:.|                 .|:|:  |||...:.   :..:::.|.:
Mosquito   610 ESSSETLLSLAEFAAPIKREPSDKSIASSISTSQSILLDDELSDEEGQADDMRHRNQQQLSVSWD 674

  Fly   647 EIASSLKAHEQQQRDRRT--RTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNL 709
            .:...:| .||..:..||  :..|.|||||::|||..|.:||:|||.||.|:|||:|||:|||||
Mosquito   675 SLEQLIK-REQTLQSARTADQNSLTRLRFKSKINPTSNKAAESELQTEITKDDFAKMEIVGQFNL 738

  Fly   710 GFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKN 774
            |||||:|.||||||||||||||||||.|||||.|:.|||.|||.|||||||||||::::||||.|
Mosquito   739 GFIIVRLGDDLFIVDQHATDEKYNFEDLQRTTVLQNQRLVVPQPLELTAVNEMVLIDNLDVFEMN 803

  Fly   775 GFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTICRPSRVRAMFASRACR 839
            |||||||..||.||||||:.||:|:.||||||||||||||:|||| .|:||||||||||||||||
Mosquito   804 GFKFEVDGAAPTTKKVRLMAKPYSRNWEFGKEDIDELIFMMQDAP-STVCRPSRVRAMFASRACR 867

  Fly   840 KSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLINIAMLINSD 890
            ||||||.|||.. .|.|||..||||:|||||||||||||||:|:||:...|
Mosquito   868 KSVMIGRALSVR-EMERLIRHMGEIDQPWNCPHGRPTMRHLVNLAMIRQID 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	213/351 (61%)
		mutL	33..880	CDD:234630	459/927 (50%)
Pms2	XP_061519472.1	None