Protein Alignment Pms2 and mlh3

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_031746133.1
• Gene: mlh3 / 100493832
• XenbaseID: XB-GENE-991852
• Length: 1316
• Species: Xenopus tropicalis
• Alignment Length: 891
• Identity: 183/891 - (20%)
• Similarity: 326/891 - (36%)
• Gaps: 234/891 - (26%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            |:.:.|:..||:.||..:.|:...|:|||.|||||.:|.:.::: |.....::|.|||||:...:
 Frog     2 IRCLKKEVQHKLRSGVTISSVGQCVEELVLNSIDALSTCIAVRI-DLETVRIQVVDNGSGLCPED 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMV-IQTRHKSTDVGVKVELDHEGR- 154
            |:.:..:|.|||.....||..::..||||||::|:..:|.:| |.::.|:|. ....:|...|:
 Frog    66 LDRLGMRYFTSKCHSLNDLENLKFHGFRGEAIASIADVSSIVEISSKCKNTS-KTFYKLIQNGKL 129

  Fly   155 --IKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNH 217
              :::.:......|||..:.|||..|||||:...:.:  ||..:.|.:::..|:...:.....|
 Frog   130 LSVQEANTSRPSAGTTFSVYNLFYNLPVRRKCMDQTV--EFENIRQRVESLSLIHPSISFSLKN- 191

  Fly   218 TPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTT 282
              ....::|||....::|.:....|:|..::..|..:          :.::|
 Frog   192 --DAMHSVVLQLAKTKDVCSRFCQIYGLPRSQKLCEI----------QHKVR------------- 231

  Fly   283 SPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSR-------------------- 327
                           :|.:.|:| ||.   |..::..|:.:||:|
 Frog   232 ---------------EFDMWGYI-SCE---GHYNKRMQYLYVNNRLVLKTKLHQHIDFLLRKESL 277

  Fly   328 PCDPKNI----------AKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINN--- 379
            .|.||||          ::...|:|        ....:||....|:.||...|.|..:...:
 Frog   278 ICKPKNINVGKTSSPGRSRSCQELY--------GIFIININCHYSEYDVCFEPAKTLIEFKDWDT 334

  Fly   380 -----ERILLLALKKSLL-------DTFGQTPATF--------------------------QMQN 406
                 |..:...||:..|       ||.|::.:.|                          ..:|
 Frog   335 VLRFVEEGVKAFLKREKLYVEPPKEDTLGKSESNFIACTDFQLVKKQDIEVFKDACCNVRHNYEN 399

  Fly   407 TTIVSMLEPKTNSGKTKFPK------ESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKG 465
            :.:.|....:|.:..|:...      ..:.:..|:.:.|.:.         |.:::.||..
 Frog   400 SILQSKSVCRTANVSTQVLNVNATIHNDTSESTHDSILECNT---------DKISKSRRFS---- 451

  Fly   466 TAPSVPVKRRCSESEELVTRTLKMQK-------IHTFLSQESPNEQSSKCEA--ESDAASDVDMA 521
                   .|.|:|:|.....|.:.|:       ..||...|.....::.|.|  :.||..:.:.|
 Frog   452 -------PRNCNENEFCAAPTTECQQDTGEKCNADTFSHAECSELPNNSCCAVIQIDACENENSA 509

  Fly   522 KKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDC----KVLTPIKSRRS-----IFE-- 575
            ::.:|.........|.:..|.... |..||..::...|.|    ..|.|..|..|     :|:
 Frog   510 QEKQTDGQCGAEQCNTQSAATLCN-YKDLTVDESASGIGCFRLLNHLCPNPSMHSSKAEGLFKLF 573

  Fly   576 -----------FKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEME 629
                       ||.::..|:....|....|. ||:::::||.       ..|.:...:.|.....
 Frog   574 SRPGPLSGQEMFKNNSHTLNSSTRPNSKGSL-PSYSKITEER-------KKITVSKNVSFANAEP 630

  Fly   630 EGLPSN------------FSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFK-TEINPNQ 681
            ....||            .:..|...:.::....|:|....|....|.|....|..| |::|..|
 Frog   631 RTTISNSTKKNCNRLLGLVAQRESLETFKQYFGKLQASTSCQSAPATVTSDTSLYLKHTDLNLCQ 695

  Fly   682 NTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQ 746
            |.|::.....|:.:|:|....     ||.|        .|.|::..:.|:......|.....:.|
 Frog   696 NNSSKNTHCNEVVEENFTSSN-----NLMF--------QFPVNEITSSEEILIPMSQNPKSPDPQ 747

  Fly   747 RLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRL 792
            .   |:...||       |.|.:..::.|...::...:.|.|..:|
 Frog   748 H---PKESPLT-------LPHYERLKQTGSSAQITFGSLAAKLSKL 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	93/382 (24%)
		mutL	33..880	CDD:234630	181/885 (20%)
mlh3	XP_031746133.1	HATPase_MutL-MLH-PMS-like	9..192	CDD:340403	59/189 (31%)
		MutL_Trans_MLH3	206..348	CDD:239568	30/191 (16%)
		MutL_C	1022..1201	CDD:214857