Protein Alignment Pms2 and pms2

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_002932025.1
• Gene: pms2 / 100490402
• XenbaseID: XB-GENE-998793
• Length: 848
• Species: Xenopus tropicalis
• Alignment Length: 914
• Identity: 390/914 - (42%)
• Similarity: 531/914 - (58%)
• Gaps: 119/914 - (13%)

  Fly    19 PTTALSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDN 83
            |::.|:..||.|.:.:||:|||||||||||.|||||:|||||||||.::||||:.|.:|:|||||
 Frog     5 PSSELAKAIKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDN 69

  Fly    84 GSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVE 148
            |.||||.|.||:|.|:||||:::|.||:.|||||||||||||||||||:.|.|.||:..||.::.
 Frog    70 GCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLV 134

  Fly   149 LDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRIL 213
            .||.|:|.::||.:|..||||.:..||.|||||.::|.||:|||||||.|:|||||:::.||||.
 Frog   135 YDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRIT 199

  Fly   214 CSNHTPKGAKTIVLQTHGD-QEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGAD 277
            |:|...:|.:..|:.:.|. .:|..||.|:||.:|...|:|..      ||..:|...: |.|..
 Frog   200 CTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPFV------QLPPSETVCE-EYGLI 257

  Fly   278 LADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVY 342
            ..||.             ...:.:.|:||.|.||.||||.||||||:|.|||||..::|::||||
 Frog   258 HEDTP-------------HGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVY 309

  Fly   343 HRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQMQNT 407
            |.||..|.||:.|||..:...||:|:||||||:|:..|::||..||.||...|..|.....|..|
 Frog   310 HLYNRHQYPFVVLNICVSSECVDINVTPDKRQILLQEEKLLLALLKTSLNAVFSSTVNKLGMNQT 374

  Fly   408 TIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAP-SVP 471
                :::....|.|......:|....|.:...    :.:..|..:..:..:       ||| |.|
 Frog   375 ----LVDAAGTSRKLNLQALASPPSDHTDAKS----SLAVSRLKEAFSHHQ-------TAPASSP 424

  Fly   472 VKRRCSESEELVTRTLKMQKIHTFLSQESPNEQS----------------------SKCEAESDA 514
                       :|:.:|.|       |.|||::.                      |:.|.:::.
 Frog   425 -----------LTKPIKAQ-------QPSPNQRKLVSFFSMNPKECVASRPSGRIHSESEIKNEH 471

  Fly   515 ASDVDMAKKDKTQVSLDNS-----------FLNLKELAKESEAYDLLTKPQ--NTPRIDCKVLTP 566
            .:.:.:...||.:...|:.           .....||:...........|:  :|....|.|
 Frog   472 GNSLTLGADDKLESDCDSGKGSSSVPDSEVGCTTPELSSHQSGESETGSPETLHTAENKCAV--- 533

  Fly   567 IKSRRSIF-----EFKTDAMALDKQESPAELNSQPPSFTQLSEETD----IASDEDDHIELPTRI 622
             :..|:|.     .:..:...:|....|:..:...|:..:...|.|    ..:.:.|.::.|..|
 Frog   534 -EHSRAILGQEDEPYPEELAQIDIALKPSYCDDTIPTCKRAKVEDDALPSACTVQPDTVDAPMNI 597

  Fly   623 EFDEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEA 687
            :     ....|..||...:|..:|.|....:..|:.:|.|         ||:.:|||..|.:||.
 Frog   598 Q-----RRTKPLPFSMANLTKGMERIKQQQRIKEETERYR---------RFRAKINPGDNQAAED 648

  Fly   688 ELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQ 752
            ||::||.||.||:|||||||||||||.||:.|||::||||||||||||.||:.|.|:.|||..||
 Frog   649 ELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEMLQQETVLQGQRLIAPQ 713

  Fly   753 NLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQD 817
            .|.||||||.||::::|:|:||||.|..|.|||.|::|:|:..|.||.|.||::||:||||||.|
 Frog   714 KLHLTAVNETVLIDNLDIFKKNGFDFIFDEEAPITERVKLISLPTSKNWTFGQQDIEELIFMLSD 778

  Fly   818 APEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLIN 882
            :| |.:|||||||.|||||||||||||||||:.: .|::|:|.|||||.|||||||||||||:.|
 Frog   779 SP-GVMCRPSRVRQMFASRACRKSVMIGTALNVH-EMKKLVTHMGEIEHPWNCPHGRPTMRHIAN 841

  Fly   883 IAML 886
            :.|:
 Frog   842 LDMI 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	187/351 (53%)
		mutL	33..880	CDD:234630	382/892 (43%)
pms2	XP_002932025.1	mutl	11..342	CDD:273155	186/350 (53%)
		mutL	12..844	CDD:234630	387/904 (43%)