Protein Alignment Pms2 and mlh1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_002933455.3
• Gene: mlh1 / 100170640
• XenbaseID: XB-GENE-5838711
• Length: 749
• Species: Xenopus tropicalis
• Alignment Length: 878
• Identity: 186/878 - (21%)
• Similarity: 367/878 - (41%)
• Gaps: 217/878 - (24%)

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            ::|.|:.:.:..|::|.:|:|:...|.|:||::||.:||.:|.:::.:||.|::.:::.|||:|:
 Frog     1 MAGVIRRLEETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVTVKDGGMKLIQIQDNGTGI 65

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDH- 151
            .:.:|:.:..::.|||::.|.||..:.|:|||||||:|:..::.:.|.|  |:.|........:
 Frog    66 RKEDLDIVCERFTTSKLQSFEDLSNISTYGFRGEALASISHVAHVTITT--KTADGKCAYRASYA 128

  Fly   152 EGRIK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCS 215
            :|::| ...|||...||.:.:.:||..:..||:.. ::..:|..::.:::..|.:...|:    |
 Frog   129 DGKLKTPPKPCAGNQGTQISVEDLFYNISTRRKAL-KSPSEEHARIVEVVSRYAIHNSGI----S 188

  Fly   216 NHTPKGAKTIV-LQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLA 279
            ....|..:|:. ::|..:...:.||..:||...:.:|:
 Frog   189 FSVKKQGETMADVRTLSNATTVDNIRTVFGNAVSRELI--------------------------- 226

  Fly   280 DTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFF--FVNSRPCDPKNIAKVMNEVY 342
                 ::..|: |:|   .|:::|::::..:     |..:..|  |:|:|..:...:.|.:..||
 Frog   227 -----EVGCEE-EKL---AFKMKGYVTNANY-----SMKKCIFLLFINARLVESTALKKAIETVY 277

  Fly   343 HRYNVQQ-QPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSL-LDTFGQTPATFQMQ 405
            ..|..:. .||:||::..|..:||||:.|.|.::...:|..::..:::.: ....|...:.....
 Frog   278 AAYLPKNTHPFLYLSLEIAPQNVDVNVHPTKHEVHFLHEDSIIERVQQHIESKLLGSNSSRMYFT 342

  Fly   406 NTTIVSMLEPKTN---SGKTKFPKESSKDDQHEE--VSEEDVPTTSTQRFMD-----------VL 454
            .|     |.|..:   |..||.|..||...:..|  .:.:.|.|.|.::.:|           :|
 Frog   343 QT-----LLPGNSVCASNVTKPPPASSTSQKSSEKVYAHQMVRTDSREQKLDAFLQPVNRPPLIL 402

  Fly   455 TQWRRTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAA---- 515
            :..:...:.:|...|    |..||..|: ..|..::.:....:..:|:....|.:...|:.
 Frog   403 SDCQAPDNAEGQKDS----RLPSEDTEM-AETSDLEMLDVLEATANPDNSVLKQKETDDSTNIVQ 462

  Fly   516 --------SDVDMAKKDKTQVSLD------------NSFLNLKELAKE---SEAYDLLTKPQNTP 557
                    |||:|.::|::..||.            .|.|:|::..:|   |...|:|   :|..
 Frog   463 PRKRPRKESDVEMVEEDESVKSLTAASMPRRRIINLTSILSLQKKIEECGHSSLQDML---RNHS 524

  Fly   558 RIDCKVLTPIKSRRSIFEFKTDAMALDKQESPAELNSQPPSF-------TQLSEET---DIA--- 609
            .:.|  :||   :.::.:|:|....|:..:...||..|...:       .:|||..   |:|
 Frog   525 FVGC--VTP---QWALAQFQTKLYLLNTTKLSQELFYQILIYDFGNFGIMKLSEPAPLYDLAMLA 584

  Fly   610 --SDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLR 672
              |.|....|       ::..:|||            .|.|...||
 Frog   585 LDSTESGWTE-------EDGPKEGL------------AEYIVQFLK------------------- 611

  Fly   673 FKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLED--------DLFIV----DQ 725
                        .:||:.     .|:..:||..:.||..:.:.|::        .|||:    :.
 Frog   612 ------------KKAEMM-----ADYFSLEIDQEGNLIGLPILLDNYIPPMEGLPLFILRLATEV 659

  Fly   726 HATDEKYNFETLQRTTQLEY--QRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATK 788
            :..|||..||:..:...:.|  ::..:.:.....|.||       .:...:.:::..:|......
 Frog   660 NWDDEKECFESFSKECSMFYSIRKQYILEESSSNADNE-------SLTGSSSWRWTTEHILYKAF 717

  Fly   789 KVRLL-GKPHSKRWEFGKEDIDELIFMLQDAPE 820
            :..|| .||.|:         |..|..|.:.|:
 Frog   718 RTHLLPPKPFSE---------DGSILQLANLPD 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	185/875 (21%)
		HATPase_c	46..>151	CDD:294057	36/104 (35%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	30/145 (21%)
		MutL_C	703..847	CDD:214857	26/133 (20%)
mlh1	XP_002933455.3	mutl	3..312	CDD:273155	90/356 (25%)
		Mlh1_C	497..749	CDD:406741	62/324 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010