Protein Alignment unc-5 and UNC5A

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_011532988.1
• Gene: UNC5A / 90249
• HGNCID: 12567
• Length: 997
• Species: Homo sapiens
• Alignment Length: 930
• Identity: 258/930 - (27%)
• Similarity: 389/930 - (41%)
• Gaps: 182/930 - (19%)

  Fly   120 PGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGS-SQPPPSTHETHVDPHTGVN 183
            ||...:.||.||:|||.|::|||:|.:|.|||..:.|:.|||:|. .:......|...|..:|:.
Human    36 PGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLP 100

  Fly   184 MEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSR 248
            ..||...:.|..|::.||...:.|:|.||||.|..|||.|.:.|||:||:|.|.|.:..:.|...
Human   101 TMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQG 165

  Fly   249 AELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVS-AGTLIFRQVALQHMANYSCSAENIAGRR 312
            ..|.|.||.|.|..::.|.:|..::....:|.:.:: ..:|:.||..|...|||:|.|:||..||
Human   166 IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARR 230

  Fly   313 VSDSAVLIVYVNGGWSTWSPWRECKCAGKPSQGR---KRSRTCNNPMPLNGGAQCPGPQIQKSAD 374
            .|.||.:|||||||||||:.|..|..    |.||   ||||:|.||.||||||.|.|..:||:|.
Human   231 RSASAAVIVYVNGGWSTWTEWSVCSA----SCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTAC 291

  Fly   375 CAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGD 439
            ...||.|                 ..||.||.||.|..:|...|.|:|
Human   292 ATLCPVD-----------------GSWSPWSKWSACGLDCTHWRSREC----------------- 322

  Fly   440 LLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQC---QIG 501
                                            ||..|..|...|.|.|:.|..|..:.|   ..|
Human   323 --------------------------------SDPAPRNGGEECQGTDLDTRNCTSDLCVHTASG 355

  Fly   502 KDDFDWTLYLGLAFITAVCFAFGTALI----CCARRGIRTNPHYNMARSVMDADYMP-GVVEKKE 561
            .:|.  .||:||..: |||......::    |..:.|:.::.   ...|::.:.:.| .:...|.
Human   356 PEDV--ALYVGLIAV-AVCLVLLLLVLILVYCRKKEGLDSDV---ADSSILTSGFQPVSIKPSKA 414

  Fly   562 MRMHI-----EASNMGYDYV--------NPGHRY-LPGEHIMGMGIGCGGVTEHHYDVPNLSANY 612
            ...|:     :.|.....|.        .|..:: |...|::. .:|.|..|.||
Human   415 DNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLS-PLGGGRHTLHH---------- 468

  Fly   613 TNPIDHLSVDYLSETGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLF 677
                       .|.|.|:....:..||  .|...|:...:.:.||......||:|.:....:.|.
Human   469 -----------SSPTSEAEEFVSRLST--QNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLL 520

  Fly   678 VPEHAIGKHVKKHVSLLLLSDECSRV---SCATESSILCSSVVHSAPRNYSFVKPVILKIPHC-L 738
            :|..||.:.....:.|.|...|..|:   .|.|    |.|.:|...|......:||||.:.|| .
Human   521 IPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQT----LLSPIVSCGPPGVLLTRPVILAMDHCGE 581

  Fly   739 VAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPR 803
            .:|:.|.:.:.....|.     :|...:.:|||..:...:.||||:..::.|||||.|.:|.|..
Human   582 PSPDSWSLRLKKQSCEG-----SWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEAL 641

  Fly   804 IQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNS 868
            ....:.::|||.|:. ...::...::|:|.:.|..::......:|.:|||..:.|.:|..|..:.
Human   642 SVAAAKRLKLLLFAP-VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSY 705

  Fly   869 RNLNIRVRSADVEAA-------APYEHAIPYQHILSNNS-ILHCEFSLRRQDQNS---LCVDFGQ 922
            .||.:.:.  ||.::       ..|:. ||:.||.:... .|||.|:|.|...::   .|
Human   706 HNLRLSIH--DVPSSLWKSKLLVSYQE-IPFYHIWNGTQRYLHCTFTLERVSPSTSDLAC----- 762

  Fly   923 GSEDDYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRL-ICGALD 986
                     .:....:.|..:..:...|.| .:|.:|.....:|  ...|||.:.:.. ...||.
Human   763 ---------KLWVWQVEGDGQSFSINFNIT-KVDGRGCRTAVTC--SHYQLPTSPQNAPALPALP 815

  Fly   987 P------PRAD---ERDWRL 997
            |      |:|.   |..|:|
Human   816 PTLPPACPQAHLLLETPWQL 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	28/85 (33%)
		Ig strand B	249..253	CDD:409389	1/3 (33%)
		Ig strand C	263..267	CDD:409389	0/3 (0%)
		Ig strand E	286..290	CDD:409389	1/3 (33%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	1/2 (50%)
		TSP1	327..379	CDD:214559	27/54 (50%)
		TSP1	401..>422	CDD:214559	10/20 (50%)
		ZU5	656..752	CDD:470600	27/99 (27%)
		UPA	810..915	CDD:465384	29/112 (26%)
		Death_UNC5-like	973..1064	CDD:260051	10/35 (29%)
UNC5A	XP_011532988.1	Ig	153..239	CDD:472250	28/85 (33%)
		Ig strand B	166..170	CDD:409353	1/3 (33%)
		Ig strand C	180..184	CDD:409353	0/3 (0%)
		Ig strand E	204..208	CDD:409353	1/3 (33%)
		Ig strand F	218..223	CDD:409353	3/4 (75%)
		Ig strand G	232..235	CDD:409353	1/2 (50%)
		TSP1	245..296	CDD:214559	27/54 (50%)
		TSP1	301..349	CDD:214559	20/96 (21%)
		ZU5	495..598	CDD:128514	27/106 (25%)
		UPA	645..782	CDD:465384	31/154 (20%)