Protein Alignment unc-5 and UNC5C

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_005263378.1
• Gene: UNC5C / 8633
• HGNCID: 12569
• Length: 950
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 307/1044 - (29%)
• Similarity: 446/1044 - (42%)
• Gaps: 210/1044 - (20%)

  Fly    93 SSSGLGSSGAAGGSGI---LLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHS 154
            |:||.||  ||.....   |.|.|      |.:....||.||||||..::|||:|..|.||||.:
Human    32 SASGTGS--AAQDDDFFHELPETF------PSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPA 88

  Fly   155 LQVIFKCSGSSQPPPSTH--ETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGV 217
            .|:.|||: |.......|  :..||..:|:.:.||:..|.|..|:|.||...:.|:|.||||.|.
Human    89 TQIYFKCN-SEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152

  Fly   218 VKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVI--TADSEPG 280
            .||:.|.|.|||:||:|.|.|....:.|.....|:|.||.|.|..::.|.||..:|  ..|....
Human   153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFY 217

  Fly   281 ITVSAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPS 343
            ||:. ..||.:|..|...|||:|.|:||..:|.|.:|.:|||||||||||:.|..|  :| |:..
Human   218 ITID-HNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRC-GRGY 280

  Fly   344 QGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWS 408
            |  ||:|||.||.||||||.|.|..:||.|....||.|                 .||:.||.||
Human   281 Q--KRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVD-----------------GRWTPWSKWS 326

  Fly   409 ICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSD 473
            .|..||...|||:|.                                       :|:...|
Human   327 TCGTECTHWRRRECT---------------------------------------APAPKNG---- 348

  Fly   474 IIPGYGKSLCAGKDIQTAECRGEQC--------------------QIGKDDFDWTLYLGLAFITA 518
                 ||. |.|..:|:..|....|                    ....|..|..||:|:.....
Human   349 -----GKD-CDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVI 407

  Fly   519 VCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPG---VVEKKEMRMHIEASNMGYDYVNPGH 580
            ||.|....:.....|    ..|.:....::|:..:.|   .|..|..|..:.|
Human   408 VCLAISVVVALFVYR----KNHRDFESDIIDSSALNGGFQPVNIKAARQDLLA------------ 456

  Fly   581 RYLPGEHIMGMGIGCGGVTEHHYDV----PNLSANYTNPIDHLSVDYLSETGESSTAD-----TS 636
              :|.:......:..|.|...| ||    |..::...:|:.:|.:...:.:|..:..|     ||
Human   457 --VPPDLTSAAAMYRGPVYALH-DVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTS 518

  Fly   637 NSTFDM------NGKLSILNASKSSTYEMLGSAGGQLRLYGGELL-------LFVPEHAI--GKH 686
            ..:..|      |..||:.|.|.:...:...:|.|.....||.|:       |.:|..||  |:.
Human   519 KLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRV 583

  Fly   687 VKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAP--EQWHVHIY 749
            .:.:|:  :...|..|.. ..:|..|.:.||...|......:||:|.:.|| ..|  |.|.:.:
Human   584 YEMYVT--VHRKETMRPP-MDDSQTLLTPVVSCGPPGALLTRPVVLTMHHC-ADPNTEDWKILL- 643

  Fly   750 HADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLL 814
                ::......|...|.||||...||.::||:|....|:||.|..:.:|.....:..:.::||.
Human   644 ----KNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLA 704

  Fly   815 AFSQHTPP---SNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVR 876
            .|.    |   |:...|:|:|.:.|..::.....::|.::||..|.|.:...|..::.||.:.:.
Human   705 IFG----PLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIH 765

  Fly   877 SADV-------EAAAPYEHAIPYQHILSNNS-ILHCEFSLRRQDQNS------LCVDFGQGSEDD 927
              |:       :..|.|:. ||:.|:.|.:. .|||.|:|.|...|:      |||...:| |..
Human   766 --DIAHSLWKSKLLAKYQE-IPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEG-EGQ 826

  Fly   928 YYTFNIP-AHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRAD 991
            .:..|.. :...:|....|....||..::.....:          .:|...::.:|.:||.|:..
Human   827 IFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAF----------SIPLPIRQKLCSSLDAPQTR 881

  Fly   992 ERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGR 1056
            ..|||:||.|||.|||:.|||||:|||..||:|||.: |...|:.|        .|...|:||||
Human   882 GHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQ-NFPDGNLS--------MLAAVLEEMGR 937

  Fly  1057 QDVL 1060
            .:.:
Human   938 HETV 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	30/86 (35%)
		Ig strand B	249..253	CDD:409389	1/3 (33%)
		Ig strand C	263..267	CDD:409389	0/3 (0%)
		Ig strand E	286..290	CDD:409389	1/3 (33%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	1/2 (50%)
		TSP1	327..379	CDD:214559	27/53 (51%)
		TSP1	401..>422	CDD:214559	11/20 (55%)
		ZU5	656..752	CDD:470600	26/106 (25%)
		UPA	810..915	CDD:465384	30/115 (26%)
		Death_UNC5-like	973..1064	CDD:260051	38/88 (43%)
UNC5C	XP_005263378.1	Ig	171..257	CDD:472250	30/86 (35%)
		Ig strand B	184..188	CDD:409353	1/3 (33%)
		Ig strand C	198..202	CDD:409353	0/3 (0%)
		Ig strand E	222..226	CDD:409353	1/3 (33%)
		Ig strand F	236..241	CDD:409353	3/4 (75%)
		Ig strand G	250..253	CDD:409353	1/2 (50%)
		TSP1	263..314	CDD:214559	27/53 (51%)
		TSP1	319..367	CDD:214559	20/96 (21%)
		ZU5	547..650	CDD:128514	26/111 (23%)
		UPA	697..836	CDD:465384	37/146 (25%)
		Death_UNC5C	863..945	CDD:260064	38/88 (43%)