DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-5 and unc5a

DIOPT Version :9

Sequence 1:	NP_001286450.1	Gene:	unc-5 / 36703	FlyBaseID:	FBgn0034013	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	XP_021336747.1	Gene:	unc5a / 799734	ZFINID:	ZDB-GENE-080219-19	Length:	916	Species:	Danio rerio

Alignment Length:	1007	Identity:	298/1007 - (29%)
Similarity:	437/1007 - (43%)	Gaps:	201/1007 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGSSQPPPSTHETH------VDP 178
            |...|:.||.|||||:.|::|||:|..|.|:::.:.|:.|||:|.     ..|:..      |||
Zfish    44 PVAFSDQLPHFLIEPDDVYIVKNKPVTLTCRSTPATQIYFKCNGE-----WVHQDQHLIDRDVDP 103

  Fly   179 HTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRL 243
            .||:.:.:|...|.|..|::.||...:.|:|.|||:.|..|||.|.|.|||:||:|.:.|....:
Zfish   104 ATGLPVMQVKIDISRQQVEKIFGLEDYWCQCVAWSTTGTQKSQKAFVRIAYLRKNFEEEPLGKEV 168

  Fly   244 ELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG-TLIFRQVALQHMANYSCSAEN 307
            .|.....|||.||.|.|..::.|.:|..:|...::|...::.. .||.:|..|....||:|.|:|
Zfish   169 ALDQELLLRCHPPEGVPPAEVEWQRNEELIDPKTDPNFFITTDHNLIIKQTRLADTGNYTCVAKN 233

  Fly   308 IAGRRVSDSAVLIVYVNGGWSTWSPWRECKC-AGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQK 371
            |..||.|.||.:|||||||||||:.|..|.. .|:..|  ||||:|.||.|||||..|.|..:||
Zfish   234 IVARRKSSSATVIVYVNGGWSTWATWSSCSAVCGRGWQ--KRSRSCTNPTPLNGGTSCEGQSLQK 296

  Fly   372 SADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEE 436
            ||..|.||.|                 ..||.||.||.|.|:|...|.|:|     ||
Zfish   297 SACTATCPVD-----------------GGWSEWSKWSPCGADCSMWRSREC-----TQ------- 332

  Fly   437 AGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQC-QI 500
                                       |:..||         ||. |.|.|:|:..|..||| |.
Zfish   333 ---------------------------PTPGTG---------GKD-CQGLDLQSLNCTSEQCPQT 360

  Fly   501 GKDDFDWTLYLGLAFITAVCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKKEMRMH 565
            .....|..||:|:..: |:|.|....::...         |...:..:|||    |.:...:...
Zfish   361 ASGAEDVALYVGMVTV-ALCLALLLVVLVLV---------YRRKKEGLDAD----VADSSILTTG 411

  Fly   566 IEASNMGYDYVNPGHRYLP-------GEHIMGMGIGC--------GGVTEHHYDVPNLSANYTNP 615
            .:.  ||.....|| .:.|       ..|::.:....        |.:...|......|.:....
Zfish   412 FQP--MGIKPSKPG-VWAPRRAARCKNSHLLTIQPDLTTSTSSYQGSLRSRHEVSSKFSMSNGPL 473

  Fly   616 IDHL-SVDYLSETGE-SSTADTSNSTFDMNGKLSILNASKSST-YEMLGSAGGQLRLYGGELLLF 677
            :|.| :..:....|: ||.||...|.......|..|.....:| |......||:|.|....:.|.
Zfish   474 LDPLPNGSHTLHNGKLSSDADDFMSRLSSQTYLKTLPRENGNTSYGTFNFLGGRLTLPNTGISLL 538

  Fly   678 VPEHAIGKHVKKHVSLLLLSDECSRV---SCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLV 739
            :|..||.:.....:.|.:...|..|:   .|.|    |.|.||...|......:||||.:.||..
Zfish   539 IPPEAIPRGKIYEIYLTIQKKEDMRLPLAGCQT----LLSPVVSCGPPGVMLTRPVILCMDHCSD 599

  Fly   740 A-PEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPR 803
            | .|.|.:.:.....|.     .|...:.:||:.::.|.:.||||....:.|||||.|.:|.|..
Zfish   600 ACLENWAIRLKKQSYEG-----TWEDVLLLGEDLLSEPYYCQLEAETCRVFTEQLGRFALVGESL 659

  Fly   804 IQQPSIKMKLLAFSQHTPPSNANCS-----LRIYVVKDFPNSRDICANV---EAKLGGSFLGESQ 860
            ....:.::|||.|:.      |.||     :|:|...|   ::|:...|   |.:|||..:.|..
Zfish   660 SMAAAKRLKLLLFAP------AYCSTLEYNIRVYCTDD---TQDLLKEVMQMERQLGGRLIDEPH 715

  Fly   861 VFAFTLNSRNLNIRVRSADVEAAAPYEH----------AIPYQHILSNNS-ILHCEFSLRRQDQN 914
            |..|..:..||.:.:..      .|:.|          .||:.||.|.:. .|||.|:|.||..:
Zfish   716 VLLFKDSYHNLRLSIHD------MPHTHWRSKLLAGYQEIPFYHIWSGSQRTLHCSFTLERQSLS 774

  Fly   915 ------SLCVDFGQGSEDDY-YTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFV- 971
                  :|||...:|....: ..|||        |:::....:..:.:        |:|.....
Zfish   775 TSDLSCTLCVWQVEGEGQSFSLDFNI--------AKDIRPLDSDFLLL--------ENCSPALAG 823

  Fly   972 ----QLPHATKRLICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSS 1032
                |:|:..::.||.:||.|..:..||||||::|..||::::||:|:|||..||:|||
Zfish   824 PSAFQIPYLIRQKICSSLDAPCPNGADWRLLAQRLKLDRHMSFFASKSSPTSVILDLWE------ 882

  Fly  1033 PGSSSNSVSHTIMALLLTLKEMGRQDVLDIIV 1064
               :.:..|..:..|...:.|:|:|:.:..:|
Zfish   883 ---TQHFHSGNLNQLAAVMAEIGKQEAMIFLV 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	29/88 (33%)
		Ig	236..321	CDD:299845	28/85 (33%)
		TSP1	327..379	CDD:214559	27/52 (52%)
		TSP1	401..>422	CDD:214559	11/20 (55%)
		ZU5	655..749	CDD:295340	29/98 (30%)
		Death_UNC5-like	973..1064	CDD:260051	31/90 (34%)
unc5a	XP_021336747.1	Ig	161..247	CDD:325142	28/85 (33%)
		TSP1	253..304	CDD:214559	27/52 (52%)
		TSP1	309..358	CDD:214559	26/97 (27%)
		ZU5	514..616	CDD:128514	29/105 (28%)
		UPA	663..802	CDD:319235	42/161 (26%)
		Death_UNC5A	829..912	CDD:260065	32/92 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595332
Domainoid	1	1.000	65	1.000	Domainoid score	I10013
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2014
OMA	1	1.010	-	-		QHG45590
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm25359
orthoMCL	1	0.900	-	-		OOG6_102612
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910