DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-5 and Unc5cl

DIOPT Version :9

Sequence 1:	NP_001286450.1	Gene:	unc-5 / 36703	FlyBaseID:	FBgn0034013	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	NP_690036.4	Gene:	Unc5cl / 76589	MGIID:	1923839	Length:	518	Species:	Mus musculus

Alignment Length:	434	Identity:	96/434 - (22%)
Similarity:	151/434 - (34%)	Gaps:	110/434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 TFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRV 703
            |..|..||.:.:|.:      :...||.|.|....:.|.:|..|:....::.|||:|:.|.....
Mouse    93 TRQMMHKLLVFSARE------VDHRGGCLILQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAP 151

  Fly   704 SCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAPEQWHVHIYHADSEHDEL--SVNWRRAV 766
            |.:.... |.|.||...|...||:||..|...||...|.|     ..|.|.:..|  :.:|:...
Mouse   152 SLSHRQG-LVSPVVACGPHGASFLKPCTLTFKHCAQQPSQ-----ACAYSSNTSLLDAKDWKPLG 210

  Fly   767 SVGEETINTPMFVQLEATHVF-----IMTEQLGHFTVVAEPRIQQPSIK-MKLLAFSQHTPPSNA 825
            ..|              ||:.     |:......:|.|.|..:.|.:.| ::|..|.....|...
Mouse   211 QPG--------------THISRDECRILLSHFSLYTCVLEAPLGQTARKWLQLAMFCSPLVPGQT 261

  Fly   826 NCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFT-------LNSRNLNIRVRSADVEAA 883
            :..||:|.:.:.|.:.......|...||...|..|:|.||       |..:.::....:.|..::
Mouse   262 HLQLRVYFLNNTPCALQWAITNEQPHGGRMRGPCQLFDFTGARADQCLKLKYISEGWENVDDSSS 326

  Fly   884 APYEHAIPYQHILSNNSILHC---EFSLRRQDQNSLCVDFGQGSEDDYYTFNIPAHSMSGSAEEL 945
                ..:|:.||....    |   .|..||:..|        |:|:           .|....|:
Mouse   327 ----QLVPHLHIWHGK----CPFRSFCFRRKAAN--------GNEE-----------CSALTNEI 364

  Fly   946 ASTTNTTISIDRQGNYVNESCVMDFVQL--------------PHATKRLICGALDPPRADER--- 993
            ..|.:|          ..:.....:|::              |..::..:|..| ||...|:
Mouse   365 IVTMHT----------FQDGLETKYVEILRFQASEEETWAVPPPVSQPPLCNRL-PPELFEQLQM 418

  Fly   994 ----------DWRLLAKKLN-TDRYIAYFATKASPTEQILNLWE 1026
                      |||.||..|. ....|.:.:.:.||...||.|:|
Mouse   419 LLEPNSVTGNDWRRLASHLGLCGMKIRFLSCQRSPAAAILELFE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352
		Ig	236..321	CDD:299845
		TSP1	327..379	CDD:214559
		TSP1	401..>422	CDD:214559
		ZU5	655..749	CDD:295340	27/93 (29%)
		Death_UNC5-like	973..1064	CDD:260051	19/82 (23%)
Unc5cl	NP_690036.4	ZU5	108..185	CDD:366307	24/77 (31%)
		Interaction with RELA and NFKB1. /evidence=ECO:0000250	186..400		48/269 (18%)
		Peptidase S68. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00485	208..235		5/40 (13%)
		UPA	243..>346	CDD:375055	23/110 (21%)
		DD	408..488	CDD:387368	17/56 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840