Protein Alignment unc-5 and Unc5a

DIOPT Version :9

• Sequence 1: NP_001286450.1
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: NP_071542.1
• Gene: Unc5a / 60629
• RGDID: 621755
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 971
• Identity: 285/971 - (29%)
• Similarity: 429/971 - (44%)
• Gaps: 174/971 - (17%)

  Fly   120 PGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGS-SQPPPSTHETHVDPHTGVN 183
            ||...:.||.||:|||.|::|||:|.:|.|||..:.|:.|||:|. .:......|...|..:|:.
  Rat    36 PGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDSSSGLP 100

  Fly   184 MEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSR 248
            ..||...:.|..|::.||...:.|:|.||||.|..|||.|.:.|||:||:|.|.|.:..:.|...
  Rat   101 TMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQG 165

  Fly   249 AELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVS-AGTLIFRQVALQHMANYSCSAENIAGRR 312
            ..|.|.||.|.|..::.|.:|..::....:|.:.:: ..:|:.||..|...|||:|.|:||..||
  Rat   166 IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARR 230

  Fly   313 VSDSAVLIVYVNGGWSTWSPWRECKCAGKPSQGR---KRSRTCNNPMPLNGGAQCPGPQIQKSAD 374
            .|.||.:|||||||||||:.|..|..    |.||   ||||:|.||.||||||.|.|..:||:|.
  Rat   231 RSTSAAVIVYVNGGWSTWTEWSVCSA----SCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTAC 291

  Fly   375 CAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGD 439
            ...||.|                 ..||:||.||.|..:|...|.|:|
  Rat   292 ATLCPVD-----------------GSWSSWSKWSACGLDCTHWRSREC----------------- 322

  Fly   440 LLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQC-QIGKD 503
                                            ||..|..|...|.|.|:.|..|..:.| .....
  Rat   323 --------------------------------SDPAPRNGGEECRGADLDTRNCTSDLCLHTASC 355

  Fly   504 DFDWTLYLGLAFITAVC-----FAFGTALICCARR-GIRTNPHYNMARSVMDADYMP-GVVEKKE 561
            ..|..||:||..: |||     .|.|  ||.|.:: |:.::.   ...|::.:.:.| .:...|.
  Rat   356 PEDVALYIGLVAV-AVCLFLLLLALG--LIYCRKKEGLDSDV---ADSSILTSGFQPVSIKPSKA 414

  Fly   562 MRMHI-----EASNMGYDYV--------NPGHRY-LPGEHIMGMGIGCGGVTEHHYDVPNLSANY 612
            ...|:     :.|.....|.        .|..:: |...|::. .:|.|..|.||
  Rat   415 DNPHLLTIQPDLSTTTTTYQGSLCSRQDGPSPKFQLSNGHLLS-PLGSGRHTLHH---------- 468

  Fly   613 TNPIDHLSVDYLSETGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLF 677
                       .|.|.|:....:..||  .|...|:...:.:..|......||:|.:....:.|.
  Rat   469 -----------SSPTSEAEDFVSRLST--QNYFRSLPRGTSNMAYGTFNFLGGRLMIPNTGISLL 520

  Fly   678 VPEHAIGKHVKKHVSLLLLSDECSRV---SCATESSILCSSVVHSAPRNYSFVKPVILKIPHC-L 738
            :|..||.:.....:.|.|...|..|:   .|.|    |.|.||...|......:||||.:.|| .
  Rat   521 IPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQT----LLSPVVSCGPPGVLLTRPVILAMDHCGE 581

  Fly   739 VAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPR 803
            .:|:.|.:.:.....|.     :|...:.:|||:.:...:.||||...::.|||||.|.:|.|..
  Rat   582 PSPDSWSLRLKKQSCEG-----SWEDVLHLGEESPSHLYYCQLEAGACYVFTEQLGRFALVGEAL 641

  Fly   804 IQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNS 868
            ....:.:::||.|:. ...::...::|:|.:.|..::......:|.:|||..:.|.:|..|..:.
  Rat   642 SVAATKRLRLLLFAP-VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSY 705

  Fly   869 RNLNIRVRSADVEAA-------APYEHAIPYQHILS-NNSILHCEFSLRRQDQNS---LCVDFGQ 922
            .||.:.:.  ||.::       ..|:. ||:.||.: ....|||.|:|.|.:.::   .|..:..
  Rat   706 HNLRLSIH--DVPSSLWKSKLLVSYQE-IPFYHIWNGTQQYLHCTFTLERINASTSDLACKVWVW 767

  Fly   923 GSEDDYYTFNIPAHSMSGS--AEELASTTNTTISIDRQGN---YVNESCVMDFVQLPHATKRLIC 982
            ..|.|..:|||..:....:  ||.||        ::.:|.   .|..|.    .::|...::.|.
  Rat   768 QVEGDGQSFNINFNITKDTRFAELLA--------LESEGGVPALVGPSA----FKIPFLIRQKII 820

  Fly   983 GALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECR--ANSSPGSSSNSVS 1041
            .:||||.:...|||.||:||:.|.::::||:|.|||..||||||.|  .|.:.|..:.:|:
  Rat   821 ASLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLGQLAAAVA 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	29/88 (33%)
		Ig	236..321	CDD:299845	28/85 (33%)
		TSP1	327..379	CDD:214559	27/54 (50%)
		TSP1	401..>422	CDD:214559	10/20 (50%)
		ZU5	655..749	CDD:295340	27/97 (28%)
		Death_UNC5-like	973..1064	CDD:260051	30/71 (42%)
Unc5a	NP_071542.1	I-set	151..239	CDD:254352	29/87 (33%)
		Ig	153..239	CDD:299845	28/85 (33%)
		TSP1	245..296	CDD:214559	27/54 (50%)
		ZU5	495..598	CDD:128514	27/106 (25%)
		Interaction with DCC. /evidence=ECO:0000250	661..679		3/17 (18%)
		Death_UNC5A	811..894	CDD:260065	30/71 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353244
Domainoid	1	1.000	91	1.000	Domainoid score	I7498
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1925
OMA	1	1.010	-	-		QHG45590
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm45956
orthoMCL	1	0.900	-	-		OOG6_102612
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910