Protein Alignment unc-5 and unc5da

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: NP_001315278.2
• Gene: unc5da / 566274
• ZFINID: ZDB-GENE-080908-2
• Length: 967
• Species: Danio rerio
• Alignment Length: 1043
• Identity: 271/1043 - (25%)
• Similarity: 423/1043 - (40%)
• Gaps: 233/1043 - (22%)

  Fly   124 SNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGS-SQPPPSTHETHVDPHTGVNMEEV 187
            |.|||.||.||:..::||:.|..|:|:|..:||:.|||:|. ......|...|::..||:.:.||
Zfish    40 SGTLPHFLQEPDDAYIVKSNPIKLRCRARPALQIFFKCNGEWVHQNQHTSLEHIELGTGLKIREV 104

  Fly   188 TATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELR 252
            ...:.|..|::|.|...:.|.|.|||..|..||:.|||.|||:||:|.|.|..:.:.:.....|.
Zfish   105 MINVSRQQVEDFHGPEDYWCLCVAWSHLGTAKSRKATVRIAYLRKNFEQEPQGMEVPINGMIVLH 169

  Fly   253 CEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG-TLIFRQVALQHMANYSCSAENIAGRRVSDS 316
            |.||.|.|..::.|.||..::.:..:..|...|. .||..:..|....||:|.|.||..||.|.:
Zfish   170 CRPPEGVPAAEVEWLKNEELVHSLEDINIDTRADHNLIINEARLSDSGNYTCLASNIVARRRSAT 234

  Fly   317 AVLIVYVNGGWSTWSPWREC--KCAGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACP 379
            |::||:||||||:|:.|.||  :| |:..|  ||:|||.||.||||||.|.|..:|||...:.||
Zfish   235 AMVIVFVNGGWSSWTDWSECNVRC-GRGVQ--KRTRTCTNPAPLNGGAFCEGMSVQKSTCTSPCP 296

  Fly   380 EDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGA 444
            .|                 ..||.|:.||.|::||.:.|.|:|
Zfish   297 VD-----------------GGWSEWTMWSECTSECERQRTREC---------------------- 322

  Fly   445 PGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQC----------Q 499
                                       :|..|.:|..||.|..:.|..|.|:.|          :
Zfish   323 ---------------------------TDPEPKHGGRLCDGAALDTDNCTGDLCIQDRKLLHDVK 360

  Fly   500 IGKDDF----DWTLYLGLA--FITAVCFAFGTAL--------------------------ICCAR 532
            :.:.|.    |..||.|||  .:|.|.......|                          ...||
Zfish   361 VPQADVESSNDVALYSGLAAGVVTVVVLVIAVTLYRRNQSEYGVDVIDSSALTGGFQSFSFKSAR 425

  Fly   533 RG------IRTNPHYNMARSVMDADYMPGVVEKK------------EMRMHIEAS---NMGYDYV 576
            :|      ....|...::|:.......|..:||:            ::::.:.:|   ::|....
Zfish   426 QGNPLLMNSSMQPDLTVSRTYTSPICFPDSMEKELIPEPALFDPLPDLKVKVHSSFMVSLGVSER 490

  Fly   577 NPGHRYLPGEHI---MGMGIGCGGVTEHHYDVPNLSANYTNPIDHLSVDYLSETGESSTADTSNS 638
            ...|...|.:..   :...||.||.|                        |...|:|.......:
Zfish   491 AEYHAKAPSQTFPRGVVQEIGGGGGT------------------------LGGRGKSQLTSIQPA 531

  Fly   639 TFD--MNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECS 701
            ...  .|||.::      .|..:.|..||:|.:....:.|.||..||.:.....:.:.:...:.|
Zfish   532 LISSMTNGKRAL------RTSGVFGHGGGRLVVPNAGVSLLVPHGAIEEDTTWELYMSITQQDSS 590

  Fly   702 RVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCL-VAPEQWHVHIYHADSEHDELSVNWRRA 765
            .:|...:..:|...|.:..| ..:...||.|.:.||. |..|.|::.:.....::     :|...
Zfish   591 ALSDEAQEILLSPEVTYGPP-GLTLSCPVALTVAHCADVNSEDWNIKLKRQTQDN-----SWEEV 649

  Fly   766 VSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLLAFSQHTPPSNANCSLR 830
            :.:.||:.:....:..:..|  ::.|:.|.:.:|.|...|....:::|.||. :..|:..|.|:|
Zfish   650 MILEEESTSCYCLLDTQCCH--LLVERPGCYALVGEALSQAAGKRLRLAAFG-NMEPNFLNYSIR 711

  Fly   831 IYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSADVE----AAAPYEHAIP 891
            :|.|.|.|::.....:||...||..|.|.:...|..||.:|.:.::  |:.    :..|:.....
Zfish   712 VYCVDDTPHAFQEVVSVERGRGGRLLEEPKTLLFRANSFSLQVSIQ--DIPQFLWSIKPFTTCQE 774

  Fly   892 Y---QHILSNNSILHCEFSLRRQD--QNSLCVDFGQGSEDDYYTFNIPAHSMSGSAEELASTTNT 951
            :   |...|:.|.|.|.|||.|..  .|.|             :..|....:.|..:.|  ...|
Zfish   775 FSFSQVWCSSQSPLQCAFSLERYSPAANQL-------------SCKISVRQVKGHEQIL--QVYT 824

  Fly   952 TISIDRQGN---YVNESCVMD------FVQLPHATKRLICGALDPPRADERDWRLLAKKLNTDRY 1007
            ||:...:..   :....|.:.      ..::|.:.::.||...|...|..:||:|||:||:.||.
Zfish   825 TIAESEKDTVPFFTQSDCTITSQTGSRAFKIPQSIRQRICATFDTANAKGKDWQLLAQKLHIDRN 889

  Fly  1008 IAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGR--------QDVLDIIV 1064
            :.|||.:.||:..||:|||.:........|         |...|:|:|:        .|.||.|.
Zfish   890 LGYFARQTSPSAVILSLWEAQHQEQGDLDS---------LASALEEIGKVQSKQSTSADTLDRIS 945

  Fly  1065 ETI 1067
            :||
Zfish   946 KTI 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	26/85 (31%)
		Ig strand B	249..253	CDD:409389	1/3 (33%)
		Ig strand C	263..267	CDD:409389	0/3 (0%)
		Ig strand E	286..290	CDD:409389	1/4 (25%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	1/2 (50%)
		TSP1	327..379	CDD:214559	27/53 (51%)
		TSP1	401..>422	CDD:214559	10/20 (50%)
		ZU5	656..752	CDD:470600	23/96 (24%)
		UPA	810..915	CDD:465384	32/113 (28%)
		Death_UNC5-like	973..1064	CDD:260051	32/98 (33%)
unc5da	NP_001315278.2	None