Protein Alignment unc-5 and Unc5c

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: NP_001402013.1
• Gene: Unc5c / 362049
• RGDID: 735109
• Length: 950
• Species: Rattus norvegicus
• Alignment Length: 1045
• Identity: 304/1045 - (29%)
• Similarity: 446/1045 - (42%)
• Gaps: 212/1045 - (20%)

  Fly    93 SSSGLGSSGAAGGSGI---LLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHS 154
            |:||.||  ||.....   |.|.|      |.:....||.||||||..::|||:|..|.||||.:
  Rat    32 SASGTGS--AAQDDDFFHELPETF------PSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPA 88

  Fly   155 LQVIFKCSGSSQPPPSTH--ETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGV 217
            .|:.|||: |.......|  :..||..:|:.:.||:..|.|..|:|.||...:.|:|.||||.|.
  Rat    89 TQIYFKCN-SEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152

  Fly   218 VKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVI--TADSEPG 280
            .||:.|.|.|||:||:|.|.|....:.|.....|:|.||.|.|..::.|.||..:|  ..|....
  Rat   153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPMAEVEWLKNEDIIDPVEDRNFY 217

  Fly   281 ITVSAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPS 343
            ||:. ..||.:|..|...|||:|.|:||..:|.|.:|.:|||||||||||:.|..|  :| |:..
  Rat   218 ITID-HNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWAEWSVCNSRC-GRGY 280

  Fly   344 QGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWS 408
            |  ||:|||.||.||||||.|.|..:||.|....||.|                 .||::||.||
  Rat   281 Q--KRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVD-----------------GRWTSWSKWS 326

  Fly   409 ICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSD 473
            .|..||...|||:|.                                       :|:...|
  Rat   327 TCGTECTHWRRRECT---------------------------------------APAPKNG---- 348

  Fly   474 IIPGYGKSLCAGKDIQTAECRGEQCQIG--------------------KDDFDWTLYLGLAFITA 518
                 ||. |.|..:|:..|....|..|                    .|..|..||:|:.....
  Rat   349 -----GKD-CDGLVLQSKNCTDGLCMQGFIYPISTEHRTQSEYGFSSAPDSDDVALYVGIVIAVT 407

  Fly   519 VCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPG---VVEKKEMRMHIEASNMGYDYVNPGH 580
            ||.|....:.....|    ..|.:....::|:..:.|   .|..|..|..:.|
  Rat   408 VCLAITVVVALFVYR----KNHRDFESDIIDSSALNGGFQPVNIKAARQDLLA------------ 456

  Fly   581 RYLPGEHIMGMGIGCGGVTEHHYDV----PNLSANYTNPIDHLSV------------DYLSETGE 629
              :|.:......:..|.|...| ||    |..::...:|:.:|.:            |.|:|...
  Rat   457 --VPPDLTSAAAMYRGPVYALH-DVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSS 518

  Fly   630 SSTADTSNSTFDMNGKLSILNAS-------KSSTYEMLGSAGGQLRLYGGELLLFVPEHAI--GK 685
            ..:...:.|..: |..|::.|.|       ..:.:....|.||.|.:....:.|.:|..||  |:
  Rat   519 KLSPQMTQSLLE-NEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGR 582

  Fly   686 HVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAP--EQWHVHI 748
            ..:.:|::....:....:.   :|..|.:.||...|......:||||.:.|| ..|  |.|.:.:
  Rat   583 VYEMYVTVHRKENMRPPME---DSQTLLTPVVSCGPPGALLTRPVILTLHHC-ADPNTEDWKIQL 643

  Fly   749 YHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKL 813
                 ::..:...|...|.||||...||.::||:|....|:||.|..:.:|.:...:..:.::||
  Rat   644 -----KNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKL 703

  Fly   814 LAFSQHTPP---SNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRV 875
            ..|.    |   |:...|:|:|.:.|..::......:|.::||..|.|.:...|..:..||.:.:
  Rat   704 AIFG----PLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSI 764

  Fly   876 RSADV-------EAAAPYEHAIPYQHILSNNS-ILHCEFSLRRQDQNS------LCVDFGQGSED 926
            .  |:       :..|.|:. ||:.||.|.:. .|||.|:|.|...|:      |||...:| |.
  Rat   765 H--DITHSLWKSKLLAKYQE-IPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEG-EG 825

  Fly   927 DYYTFNIP-AHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRA 990
            ..:..|.. :...:|....|....:|..::.....:          .:|...::.:|.:||.|:.
  Rat   826 QIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAF----------SIPLPIRQKLCSSLDAPQT 880

  Fly   991 DERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMG 1055
            ...|||:||.|||.|||:.|||||:|||..||:|||.: |...|:.|        .|...|:|||
  Rat   881 RGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQ-NFPDGNLS--------MLAAVLEEMG 936

  Fly  1056 RQDVL 1060
            |.:.:
  Rat   937 RHETV 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	30/86 (35%)
		Ig strand B	249..253	CDD:409389	1/3 (33%)
		Ig strand C	263..267	CDD:409389	0/3 (0%)
		Ig strand E	286..290	CDD:409389	1/3 (33%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	1/2 (50%)
		TSP1	327..379	CDD:214559	27/53 (51%)
		TSP1	401..>422	CDD:214559	11/20 (55%)
		ZU5	656..752	CDD:470600	24/99 (24%)
		UPA	810..915	CDD:465384	31/115 (27%)
		Death_UNC5-like	973..1064	CDD:260051	38/88 (43%)
Unc5c	NP_001402013.1	Ig	171..257	CDD:472250	30/86 (35%)
		Ig strand B	184..188	CDD:409389	1/3 (33%)
		Ig strand C	198..202	CDD:409389	0/3 (0%)
		Ig strand E	222..226	CDD:409389	1/3 (33%)
		Ig strand F	236..241	CDD:409389	3/4 (75%)
		Ig strand G	250..253	CDD:409389	1/2 (50%)
		TSP1	263..314	CDD:214559	27/53 (51%)
		TSP1	319..367	CDD:214559	20/96 (21%)
		ZU5	547..650	CDD:128514	24/111 (22%)
		UPA	697..836	CDD:465384	38/146 (26%)
		Death_UNC5C	863..945	CDD:260064	38/88 (43%)