DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-5 and UNC5CL

DIOPT Version :9

Sequence 1:	NP_001286450.1	Gene:	unc-5 / 36703	FlyBaseID:	FBgn0034013	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	NP_775832.2	Gene:	UNC5CL / 222643	HGNCID:	21203	Length:	518	Species:	Homo sapiens

Alignment Length:	410	Identity:	94/410 - (22%)
Similarity:	147/410 - (35%)	Gaps:	74/410 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   645 KLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRVSCATES 709
            ||.:.:|.:      :...||.|.|....:.|.:|..|:....::.|||:|:.| .|.....:::
Human    99 KLLVFSARE------VDHRGGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWD-LSDAPSLSQA 156

  Fly   710 SILCSSVVHSAPRNYSFVKPVILKIPHCLVAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETIN 774
            ..|.|.||...|...||:||..|...||...|.  |...|.:::...:..| ||.....|.....
Human   157 QGLVSPVVACGPHGASFLKPCTLTFKHCAEQPS--HARTYSSNTTLLDAKV-WRPLGRPGAHASR 218

  Fly   775 TPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIK-MKLLAFSQHTPPSNANCSLRIYVVKDFP 838
            ....:.|  :|..:       :|.|.|..:.:.:.| ::|..|.....|..::..||||.:.:.|
Human   219 DECRIHL--SHFSL-------YTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTP 274

  Fly   839 NSRDICANVEAKLGGSFLGESQVFAFT-------LNSRNLNIRVRSADVEAAAPYEHAIPYQHIL 896
            .:.......|...||...|..|:|.|.       |....::....:.|..:.    ..:|:.||.
Human   275 CALQWALTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEGWENVDDSSC----QLVPHLHIW 335

  Fly   897 SNNSILHC---EFSLRRQ--DQNSLCV-----------DFGQGSEDDY---YTFNIPAHSMSGSA 942
            ...    |   .|..||:  |:|..|.           .|..|.|..|   ..|.        ::
Human   336 HGK----CPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRFQ--------AS 388

  Fly   943 EELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRADERDWRLLAKKLN-TDR 1006
            ||.:......:|.....|           :||......:...|:|......|||.||..|. ...
Human   389 EEESWAAPPPVSQPPPCN-----------RLPPELFEQLRMLLEPNSITGNDWRRLASHLGLCGM 442

  Fly  1007 YIAYFATKASPTEQILNLWE 1026
            .|.:.:.:.||...||.|:|
Human   443 KIRFLSCQRSPAAAILELFE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352
		Ig	236..321	CDD:299845
		TSP1	327..379	CDD:214559
		TSP1	401..>422	CDD:214559
		ZU5	655..749	CDD:295340	27/93 (29%)
		Death_UNC5-like	973..1064	CDD:260051	17/55 (31%)
UNC5CL	NP_775832.2	ZU5	103..192	CDD:279170	28/97 (29%)
		Interaction with RELA and NFKB1. /evidence=ECO:0000269\|PubMed:14769797	186..400		47/241 (20%)
		Peptidase S68. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00485	208..235		4/35 (11%)
		DD	408..488	CDD:301326	17/55 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840