DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-5 and Unc5d

DIOPT Version :9

Sequence 1:NP_001286450.1 Gene:unc-5 / 36703 FlyBaseID:FBgn0034013 Length:1072 Species:Drosophila melanogaster
Sequence 2:NP_694775.1 Gene:Unc5d / 210801 MGIID:2389364 Length:956 Species:Mus musculus


Alignment Length:1051 Identity:273/1051 - (25%)
Similarity:425/1051 - (40%) Gaps:233/1051 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 SSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVI 158
            ::|..::..|.||.||.:...|   :||    |||.|:.|||..:::|:.|..|:|||..::|:.
Mouse    25 AAGAAAARGADGSEILPDSIPS---APG----TLPHFIEEPEDAYIIKSNPIALRCKARPAMQIF 82

  Fly   159 FKCSGS-SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQA 222
            |||:|. ........|..:|..:|:.:.||...:.|..|::|.|...:.|:|.|||..|..||:.
Mouse    83 FKCNGEWVHQNEHVSEESLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRK 147

  Fly   223 ATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG- 286
            |:|.|||:||:|.|.|....:.:.....|.|.||.|.|..::.|.||...|.::.:..|...|. 
Mouse   148 ASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADH 212

  Fly   287 TLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPSQGR--- 346
            .||.||..|....||:|.|.||..:|.|.||.::||||||||:|:.|..|  :|      ||   
Mouse   213 NLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRC------GRGWQ 271

  Fly   347 KRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICS 411
            ||||||.||.||||||.|.|..:||....|.||.|                 ..|..||:||:||
Mouse   272 KRSRTCTNPAPLNGGAFCEGMSVQKITCTALCPVD-----------------GSWEVWSEWSVCS 319

  Fly   412 AECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIP 476
            .||..:|.|:|.                    ||.                             |
Mouse   320 PECEHLRIRECT--------------------APP-----------------------------P 335

  Fly   477 GYGKSLCAGKDIQTAECRGEQCQIGKDDF-----------------DWTLY--LGLAFITAVCFA 522
            ..|...|.|...::..|....|.:.|...                 |..||  ||.|.:......
Mouse   336 RNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQRWSRRGIENASDIALYSGLGAAVVAVAVLV 400

  Fly   523 FGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIEASNMGYDYVNPGHRYLPGEH 587
            .|..|.   ||.     |.:....|:|:..:.|..:....:...:.:::   .:||..:      
Mouse   401 IGVTLY---RRS-----HSDYGVDVIDSSALTGGFQTFNFKTVRQGNSL---LLNPAMQ------ 448

  Fly   588 IMGMGIGCGGVTEHHYDVPNL--SANYTNPI---DHLSVDYLSET-------------------- 627
                              |:|  |..|:.||   |.|..:.::|:                    
Mouse   449 ------------------PDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVS 495

  Fly   628 ----------GES-------------STADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRL 669
                      |::             ||....|.|..:....|:...::..|..:.|..||:|.:
Mouse   496 LGVSERAEYHGKNHSGTFPHGNNRGFSTIHPRNKTPYIQNLSSLPTRTELRTTGVFGHLGGRLVM 560

  Fly   670 YGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKI 734
            ....:.|.:|..||.:.....:.:.:...|.|..|..:|  :|.|..|...|.:.....|..|.|
Mouse   561 PNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSE--VLLSPEVTCGPPDMLVTTPFALTI 623

  Fly   735 PHCL-VAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTV 798
            |||. |:.|.|::|:.....:.     .|...:||.:|:.:....:...|.||.:  :..|.:.:
Mouse   624 PHCADVSSEHWNIHLKKRTQQG-----KWEEVMSVEDESTSCYCLLDPFACHVLL--DSFGTYAL 681

  Fly   799 VAEPRIQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFA 863
            ..|| |...::|...:|.......::.:.:||:|.|.:.|.:.....:.|...||..|.|.::..
Mouse   682 TGEP-ITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVISDERHQGGQLLEEPKLLH 745

  Fly   864 FTLNSRNLNIRVRSADVE----AAAPYE--HAIPYQHILSNN-SILHCEFSLRR------QDQNS 915
            |..|:.:|.:.|  .|:.    ...|:.  ..:|:..:.|:| ..|||.|||.|      |....
Mouse   746 FKGNTFSLQVSV--LDIPPFLWRIKPFTACQEVPFSRVWSSNRQPLHCAFSLERYTPTTTQLSCK 808

  Fly   916 LCVDFGQGSEDDYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRL 980
            :|:...:|.|.   ...:....:....|.:      |........:..::....| ::|::.::.
Mouse   809 ICIRQLKGHEQ---ILQVQTSILESERETI------TFFAQEDSTFPAQTGPKAF-KIPYSIRQR 863

  Fly   981 ICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIM 1045
            ||...|.|.|..:||::||:|.:.:|.::||||::||:..||||||.|........|        
Mouse   864 ICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQQDGDLDS-------- 920

  Fly  1046 ALLLTLKEMGR 1056
             |...|:|:||
Mouse   921 -LACALEEIGR 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-5NP_001286450.1 I-set 233..321 CDD:254352 30/88 (34%)
Ig 236..321 CDD:299845 29/85 (34%)
TSP1 327..379 CDD:214559 27/56 (48%)
TSP1 401..>422 CDD:214559 11/20 (55%)
ZU5 655..749 CDD:295340 27/94 (29%)
Death_UNC5-like 973..1064 CDD:260051 31/84 (37%)
Unc5dNP_694775.1 Ig 51..153 CDD:299845 36/101 (36%)
Important for interaction with FLRT2. /evidence=ECO:0000250|UniProtKB:F1LW30 89..91 0/1 (0%)
I-set 159..247 CDD:254352 30/87 (34%)
Ig 161..247 CDD:299845 29/85 (34%)
TSP1 253..304 CDD:214559 27/56 (48%)
TSP1 309..357 CDD:214559 19/96 (20%)
ZU5 545..640 CDD:279170 27/96 (28%)
Death_UNC5D 856..953 CDD:176779 31/84 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849591
Domainoid 1 1.000 94 1.000 Domainoid score I7440
eggNOG 1 0.900 - - E1_KOG1480
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 394 1.000 Inparanoid score I1957
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45590
OrthoDB 1 1.010 - - D169564at33208
OrthoFinder 1 1.000 - - FOG0000918
OrthoInspector 1 1.000 - - otm43868
orthoMCL 1 0.900 - - OOG6_102612
Panther 1 1.100 - - O PTHR12582
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X496
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.770

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