DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-5 and UNC5D

DIOPT Version :9

Sequence 1:	NP_001286450.1	Gene:	unc-5 / 36703	FlyBaseID:	FBgn0034013	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	XP_016868533.1	Gene:	UNC5D / 137970	HGNCID:	18634	Length:	977	Species:	Homo sapiens

Alignment Length:	1040	Identity:	273/1040 - (26%)
Similarity:	437/1040 - (42%)	Gaps:	197/1040 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SSGAAGGSGILLEEFNSGKLSP---GEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFK 160
            ::|.|...|.     ::|:..|   ..|..|||.|:.||:..:::|:.|..|:|||..::|:.||
Human    27 AAGTAAARGT-----DNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFK 86

  Fly   161 CSGS--SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAA 223
            |:|.  .|....:.|| :|..:|:.:.||...:.|..|::|.|...:.|:|.|||..|..||:.|
Human    87 CNGEWVHQNEHVSEET-LDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKA 150

  Fly   224 TVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG-T 287
            :|.|||:||:|.|.|....:.:.....|.|.||.|.|..::.|.||...|.::.:..|...|. .
Human   151 SVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHN 215

  Fly   288 LIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPSQGRKRSR 350
            ||.||..|....||:|.|.||..:|.|.||.::||||||||:|:.|..|  :| |:..|  ||||
Human   216 LIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRC-GRGWQ--KRSR 277

  Fly   351 TCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECI 415
            ||.||.||||||.|.|..:||....:.||.|                 ..|..||:||:||.||.
Human   278 TCTNPAPLNGGAFCEGMSVQKITCTSLCPVD-----------------GSWEVWSEWSVCSPECE 325

  Fly   416 QVRRRKC----------LTQGQTQISSEA--------------------EEAGDLL----LGAPG 446
            .:|.|:|          ..:|.:|.|...                    |.|.|:.    |||..
Human   326 HLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAV 390

  Fly   447 VGMAALIAAA----------GVGAVGSPSEATGSSSDIIPGYG----KSLCAGKDIQTAECRGEQ 497
            |.:|.|:...          ||..:.| |..||       |:.    |::...|:|.  |...::
Human   391 VAVAVLVIGVTLYRRSQSDYGVDVIDS-SALTG-------GFQTFNFKTVRQAKNIM--ELMIQE 445

  Fly   498 CQIGKDDFDWTLYLGLAFITAVCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKK-- 560
            ...||             ..:.|..:|.:|:.    .....|...::|:......:...::|:
Human   446 KSFGK-------------CHSPCIYYGNSLLL----NSAMQPDLTVSRTYSGPICLQDPLDKELM 493

  Fly   561 ----------EMRMHIEASNMGYDYVNPGHRYLPGEHIMGMGIGCGGVTEHHYDVPNLSANYTNP 615
                      ::::.:::|.|                   :.:|.....|:|      ..|::..
Human   494 TESSLFNPLSDIKVKVQSSFM-------------------VSLGVSERAEYH------GKNHSRT 533

  Fly   616 IDHLSVDYLSETGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPE 680
            ..|      ......||....|....:....|:...::..|..:.|..||:|.:....:.|.:|.
Human   534 FPH------GNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPH 592

  Fly   681 HAIGKHVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCL-VAPEQW 744
            .||.:.....:.:.:...|.|..|..:|  :|.|..|...|.:.....|..|.||||. |:.|.|
Human   593 GAIPEENSWEIYMSINQGEPSLQSDGSE--VLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHW 655

  Fly   745 HVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSI 809
            ::|:.....:.     .|...:||.:|:.:....:...|.||.:  :..|.:.:..|| |...::
Human   656 NIHLKKRTQQG-----KWEEVMSVEDESTSCYCLLDPFACHVLL--DSFGTYALTGEP-ITDCAV 712

  Fly   810 KMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIR 874
            |...:|.......::.:.:||:|.|.:.|.:.....:.|...||..|.|.::..|..|:.:|.|.
Human   713 KQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQIS 777

  Fly   875 VRSADVE----AAAPYE--HAIPYQHI-LSNNSILHCEFSLRR------QDQNSLCVDFGQGSED 926
            |  .|:.    ...|:.  ..:|:..: .||...|||.|||.|      |....:|:...:|.|.
Human   778 V--LDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQ 840

  Fly   927 DYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRAD 991
               ...:....:....|.:      |........:..::....| ::|::.::.||...|.|.|.
Human   841 ---ILQVQTSILESERETI------TFFAQEDSTFPAQTGPKAF-KIPYSIRQRICATFDTPNAK 895

  Fly   992 ERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGR 1056
            .:||::||:|.:.:|.::||||::||:..||||||.|........|         |...|:|:||
Human   896 GKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDS---------LACALEEIGR 951

Fly 1057 1056
Human 952 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	30/88 (34%)
		Ig	236..321	CDD:299845	29/85 (34%)
		TSP1	327..379	CDD:214559	26/53 (49%)
		TSP1	401..>422	CDD:214559	11/20 (55%)
		ZU5	655..749	CDD:295340	27/94 (29%)
		Death_UNC5-like	973..1064	CDD:260051	31/84 (37%)
UNC5D	XP_016868533.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159219
Domainoid	1	1.000	99	1.000	Domainoid score	I7072
eggNOG	1	0.900	-	-		E1_KOG1480
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1951
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45590
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm41817
orthoMCL	1	0.900	-	-		OOG6_102612
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770