Protein Alignment unc-5 and LOC1280019

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_319813.5
• Gene: LOC1280019 / 1280019
• VectorBaseID: AGAMI1_001011
• Length: 1146
• Species: Anopheles gambiae
• Alignment Length: 934
• Identity: 319/934 - (34%)
• Similarity: 492/934 - (52%)
• Gaps: 137/934 - (14%)

  Fly    65 EESAQHKNNAELLGNSSEDENVRPQQGSSSSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPI 129
            ||..:.:|::|:    |..|:|.|    .|...|:.|...|.|:.:||              .|.
Mosquito   266 EEEEEDENDSEV----SYGEDVLP----PSEAFGTFGERTGGGLKVEE--------------APY 308

  Fly   130 FLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGSSQPPPSTHETHVDPHTGVNMEEVTATIHRD 194
            ||:||::.:|::::||||||||:::||:.||||||.:||||..|:|||||:||:.:||||||.||
Mosquito   309 FLVEPQNTYVIRSKPAVLKCKAANTLQIHFKCSGSIKPPPSIEESHVDPHSGVHFQEVTATISRD 373

  Fly   195 LVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGF 259
            ||.|:||..||||||||||.||...||.|::.:||::|:|:...|.:|.|.|.:.|::|..|.|:
Mosquito   374 LVYEYFGKLPFKCECHAWSPRGKAVSQPASIVVAYLKKNFDLMDTRIRAEAGEKLEIKCMAPKGY 438

  Fly   260 PEPKLTWHKNNAVITADSEPGITVSA-GTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYV 323
            |:|::||.|||..:|  |.|.:|.:| |.::...:.||.:.||:|.||||||:|:|:...|||||
Mosquito   439 PKPQITWLKNNFTVT--SSPLLTFTAEGNIVITSLNLQDIGNYTCVAENIAGKRISEPIELIVYV 501

  Fly   324 NGGWSTWSPWRECKCAGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPD 388
            |||||.||.|.||:|.|||:|||||:|||::|:||.|||.|.||..||:|||..|||||||::|:
Mosquito   502 NGGWSQWSAWLECRCPGKPAQGRKRTRTCSDPIPLYGGAPCVGPNQQKTADCVTCPEDTQIITPN 566

  Fly   389 GFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALI 453
            ||:.::..|  |||:||.||.||.:|.|.|||.|.||.        .:..|..|......:|||:
Mosquito   567 GFEDNAFVR--RWSSWSAWSACSNKCTQSRRRTCRTQN--------IDYYDKALVKHHQQLAALM 621

  Fly   454 AAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQCQIGKDDFDWTLYLGLAFITA 518
                     ...:...||:     ||   |.|||:||..|||.:|:|.....||..||||.||..
Mosquito   622 ---------EDHDEQESSA-----YG---CHGKDVQTIVCRGGECKIDDTASDWIFYLGLGFIVT 669

  Fly   519 VCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKK--------EMRMHIEASNMGYDY 575
            :|..|...|:....|  :..|.|::.|:..|........:||        ::.:.:.    ||:|
Mosquito   670 LCLTFLVFLLHMRHR--QKLPTYSITRTTPDQHTYTHEFQKKLTLSSNPPDINIRVN----GYEY 728

  Fly   576 VNPGHRYLPGEHIMGMGIG---CGGVTEHHYDVPNLSANYTNP--------------------ID 617
            .|.....:|  .:....:.   ....:|||||.|..::...|.                    :.
Mosquito   729 SNGSTMEVP--KVPSQNVPLLLTRSTSEHHYDEPQFNSMQPNQALNKDGSAGVYNQQKLAGVILQ 791

  Fly   618 H-------LSVDYL-----------SETGESSTADTSNSTFDMNGKLSI--------LNASKS-- 654
            |       |...:|           |:.|:..::::.:.|.:.|..:|.        |:.|.|
Mosquito   792 HHYHQYHSLEQSHLQRQIASSPIAQSQKGQYRSSESLSGTSNTNTSISTYAIATTDSLDTSSSSE 856

  Fly   655 ------STYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRVSCATESSIL- 712
                  |..:::.|.||.|.:...:..|.:||.||...::.:|.|.::.|  |:.:...|:.:.
Mosquito   857 AMYKSNSVRQVVTSDGGWLEMEHLQTSLSIPEGAIPAALRINVFLAVMYD--SKDTILVENQVTH 919

  Fly   713 CSSVVHSAPRNYSFVKPVILKIPHCLVAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPM 777
            .|..:...|...:|.||:|:|:|||......|.|.:::    .:|::..|::..|...:..:...
Mosquito   920 ISPTIVCGPAKSNFTKPLIIKVPHCAEDIGSWKVSLFY----KEEVTNCWKKIASSENDVPSPQA 980

  Fly   778 FVQLEATHVFIMTEQLGHFTVVAEPRIQQPSI--KMKLLAFSQHTPPSNANCSLRIYVVKDFPNS 840
            ::||:..:.:|||.:||.:.:..|....:.::  ::|::.|.....| .|:.::|.||::|:|::
Mosquito   981 YIQLDQHNAYIMTRKLGKYLLGGESLTPEVNVTKRLKIVMFGPARKP-EADFNIRAYVLEDYPSA 1044

  Fly   841 RDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSAD--VEAAAPYEHAIPYQHILSNNSILH 903
            .:.|:.:|.:||...:|:|..|.|..|...:.:|:..:.  ..||......||:.||..|.|||:
Mosquito  1045 LEHCSGIETRLGYFQIGQSSPFHFANNKEAMTLRINCSGGWTTAAECAVQKIPFNHIWKNMSILN 1109

  Fly   904 CEFSLRRQDQNSLCVDFGQGSEDD 927
            |||.|.:......|:......|.|
Mosquito  1110 CEFLLHKLTDEMPCLRLELAVEQD 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	35/85 (41%)
		Ig strand B	249..253	CDD:409389	1/3 (33%)
		Ig strand C	263..267	CDD:409389	1/3 (33%)
		Ig strand E	286..290	CDD:409389	1/3 (33%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	1/2 (50%)
		TSP1	327..379	CDD:214559	33/51 (65%)
		TSP1	401..>422	CDD:214559	13/20 (65%)
		ZU5	656..752	CDD:470600	26/96 (27%)
		UPA	810..915	CDD:465384	33/106 (31%)
		Death_UNC5-like	973..1064	CDD:260051
LOC1280019	XP_319813.5	None