Protein Alignment unc-5 and LOC1280018

DIOPT Version :10

• Sequence 1: NP_611033.2
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_061514374.1
• Gene: LOC1280018 / 1280018
• VectorBaseID: AGAMI1_013069
• Length: 1214
• Species: Anopheles gambiae
• Alignment Length: 1193
• Identity: 401/1193 - (33%)
• Similarity: 581/1193 - (48%)
• Gaps: 224/1193 - (18%)

  Fly    24 FTLSVSGELPQLDYGSLSASLEEDAIDPLTAMAPFANSLVTEESAQ------HKNNAELLGNSSE 82
            |...||..||... |:::           .|.|||......||...      :::..|||||..|
Mosquito   102 FKSDVSTSLPAFS-GTVT-----------NAKAPFGVDDPDEEEPDDDEDDGYEDGGELLGNFDE 154

  Fly    83 DENVRPQQGSSSSGLGSSGAAGGSGIL----LEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNR 143
            |......:|.|.....|........:.    :|.|.:     |.....||:||:||:..:|:|||
Mosquito   155 DSRATEDRGPSGHKHDSLDYTDNFEVAAIDQIESFGA-----GNDGTPLPVFLVEPKGAYVMKNR 214

  Fly   144 PAVLKCKASHSLQVIFKCSGSSQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCE 208
            ||.|.|||||:||:.||||||::|||:..|.|.|||:||.::|.||||.|:|||||||.||||||
Mosquito   215 PAKLYCKASHALQISFKCSGSTKPPPTEKEHHTDPHSGVQLQEATATITRELVDEFFGKGPFKCE 279

  Fly   209 CHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVI 273
            |.|:||||.||:|..|:.:|.|:|..:.||..:|:..|.||||.| .....|..|:.|.||:..:
Mosquito   280 CRAYSSRGHVKTQPVTIQVATIKKQISISPKIVRVATGGRAELNC-IANATPAAKVVWLKNSVPV 343

  Fly   274 TADSEPGITVSAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWRECKC 338
            .| :.|.:.::...|:..:|.:|.||||:|.||||||:||||...:.|||:||||:|.||.:|||
Mosquito   344 HA-NPPFVLLTENALLIARVEIQDMANYTCVAENIAGKRVSDPVPITVYVDGGWSSWGPWTDCKC 407

  Fly   339 AGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACP-EDTQIVSPDGFDISSSKRMARWS 402
            .|...||:||:|.||:|:|:|.||.|.|...:.:.||..|. :|.|||:|:|:.:|:    .|||
Mosquito   408 PGHGKQGQKRTRVCNSPVPMNNGAPCKGASTESTPDCLPCSVDDVQIVNPNGYQLSA----GRWS 468

  Fly   403 AWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEA 467
            :||:||.|..:|.|:|:|.|:.      ||.|.:     ||:..|..|||:|.:      |.::|
Mosquito   469 SWSEWSECGPDCTQIRQRSCVG------SSSATQ-----LGSVPVTSAALVANS------SSAQA 516

  Fly   468 TGSSSDIIPGYGKSLCAGKDIQTAECRGEQCQIGKDDFDWTLYLGLAFITAVCFAFGTALICCAR 532
            ....|..|..     ||||..|:.:|.|..|.....|.:|::||.:..:.|.|.....|:....|
Mosquito   517 FAIDSGTIVN-----CAGKSQQSIKCTGGLCNYTAQDSNWSVYLWVTLVAAFCLGVVFAVSKFLR 576

  Fly   533 RGIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIE---ASNMG---YDYV------------NPG 579
            |. :|.|.||:|||.|..:|...  |.|:: .|.:   ..|.|   |:|.            :|.
Mosquito   577 RK-KTIPAYNLARSEMPTEYFAN--ESKKL-THFQPDLTQNTGPINYEYPMTASLQPHLAGHHPH 637

  Fly   580 HRYLPGEH--------------IMG---MGIG-----C----------GGV----------TEHH 602
            |.:|..:|              ::|   .|.|     |          ||:          :|||
Mosquito   638 HHHLQQQHHHHLSSLHHQHGSSLLGPVATGHGQLHPQCQSQQAPTLPIGGLKSSLPLPRSNSEHH 702

  Fly   603 YDVPNLSANYTNPIDHLSVD--YLS----------ETGESSTADTSNSTFDMNGKLSILNASKSS 655
            ||||:|..||..|:|.:|::  |.|          |:.|:||..:::||:|   :..:|..|.|.
Mosquito   703 YDVPHLCNNYIYPLDKVSINESYSSSTYSKRVCSVESLETSTNTSADSTYD---QAPMLPPSSSP 764

  Fly   656 -----------------TYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSLLLLSDECSRV 703
                             |:..|..||..|||......|.:||.||.||.:..|:|.::.|:...|
Mosquito   765 AIRPTTLVEEPFRGAEVTHATLTPAGALLRLATYSTALLIPEGAIPKHQRHSVALSIVRDDKHHV 829

  Fly   704 SCAT-ESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAPEQWHVHIYHADSEHDELSVNWRRAVS 767
            ...| ..|...|.||...|.:....||:::::|||......|...:|.|.   |.:: .|.:.|:
Mosquito   830 PVPTGPRSTYLSPVVFCGPVDTKVNKPIVMQLPHCAENLSDWAFSLYSAP---DNVT-PWCKVVT 890

  Fly   768 VGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPR--IQQ--PSIKMKLLAFSQHTPPSNANCS 828
            :||||:|||..||::..:.:::||..|.:.:|.|..  ||:  ...:::|......|.|..::.|
Mosquito   891 IGEETLNTPALVQIDKRYAYVLTETFGKYVLVGESATDIQERVACKRLRLFICGPSTVPEFSDVS 955

  Fly   829 LRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFT-LNSRNLNI--------RVRSADVEAAA 884
            ||:|:|:|.|.:.:.|.:.|.::||..||.|.|..|. :....|||        |.:|:.
Mosquito   956 LRVYIVEDNPGAEERCRHCEQEIGGVLLGRSTVLHFADVGQAGLNIDLQCVGGWRAKSSS----- 1015

  Fly   885 PYEHAIPYQHILSNN-SILHCEFSLRRQDQNSLC---------VDFGQGSEDDYYTFNIPA---- 935
             ....||:.|:.::. :.|||.|:|.|.:.:. |         .|..||.::......:||
Mosquito  1016 -ERQTIPFSHVWNSACTALHCSFTLCRTEHDK-CDFKIVVQASQDVPQGLDERLTAIGVPATLSI 1078

  Fly   936 --------------HSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALD 986
                          ||.|       |....||.....|::.......|..:|....||.:|..||
Mosquito  1079 SSFVPMAKDGRHCQHSSS-------SFETMTICSVGSGDHNTNLLATDRFRLSKDVKRKLCRCLD 1136

  Fly   987 PPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTL 1051
            ||.....|||:||..||.|||:.||||:.|||:|||:|||||         |...:.:..|:...
Mosquito  1137 PPTQKRNDWRMLAAHLNVDRYLTYFATRPSPTDQILDLWECR---------NRDLNALQQLIEIC 1192

  Fly  1052 KEMGRQDVLDIIVETIGPL--WI 1072
            :.|.|.|.: .|:|.|.|.  |:
Mosquito  1193 RTMERPDAV-AILEQIQPAAPWV 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_611033.2	Ig	236..321	CDD:472250	34/84 (40%)
		Ig strand B	249..253	CDD:409389	3/3 (100%)
		Ig strand C	263..267	CDD:409389	1/3 (33%)
		Ig strand E	286..290	CDD:409389	1/3 (33%)
		Ig strand F	300..305	CDD:409389	3/4 (75%)
		Ig strand G	314..317	CDD:409389	2/2 (100%)
		TSP1	327..379	CDD:214559	25/51 (49%)
		TSP1	401..>422	CDD:214559	11/20 (55%)
		ZU5	656..752	CDD:470600	31/96 (32%)
		UPA	810..915	CDD:465384	33/114 (29%)
		Death_UNC5-like	973..1064	CDD:260051	38/90 (42%)
LOC1280018	XP_061514374.1	None