DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-5 and Unc5b

DIOPT Version :10

Sequence 1:NP_611033.2 Gene:unc-5 / 36703 FlyBaseID:FBgn0034013 Length:1072 Species:Drosophila melanogaster
Sequence 2:NP_084046.2 Gene:Unc5b / 107449 MGIID:894703 Length:945 Species:Mus musculus


Alignment Length:1059 Identity:308/1059 - (29%)
Similarity:452/1059 - (42%) Gaps:237/1059 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 SSSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQV 157
            |.:|:.|:|.     :|.:.:      |...:..||.||:||:..::|||:|..|.|:|..:.|:
Mouse    24 SLAGVDSAGQ-----VLPDSY------PSAPAEQLPYFLLEPQDAYIVKNKPVELHCRAFPATQI 77

  Fly   158 IFKCSGS--SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKS 220
            .|||:|.  ||....|.|: :|..||:.:.||...:.|..|:|.||...:.|:|.||||.|..||
Mouse    78 YFKCNGEWVSQNDHVTQES-LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSSGTTKS 141

  Fly   221 QAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSA 285
            :.|.:.|||:||:|:|.|.:..:.|.....|:|.||.|.|..::.|.||..||....:....::.
Mouse   142 RRAYIRIAYLRKNFDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPAQDTNFLLTI 206

  Fly   286 G-TLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPSQGR- 346
            . .||.||..|...|||:|.|:||..:|.|.:|.:|||||||||:|:.|..|  :|      || 
Mouse   207 DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRC------GRG 265

  Fly   347 --KRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSI 409
              ||:|||.||.||||||.|.|...||:|....||.|                 ..|:.||.||.
Mouse   266 WQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTVCPVD-----------------GAWTEWSKWSA 313

  Fly   410 CSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDI 474
            ||.||...|.|:|:                    ||.                            
Mouse   314 CSTECAHWRSRECM--------------------APP---------------------------- 330

  Fly   475 IPGYGKSLCAGKDIQTAECRGEQCQIGKDDF------------DWTLYLGLA----FITAVCFAF 523
             |..|...|:|..:.:..|....|.:.:...            |..||.||.    .:.||..|.
Mouse   331 -PQNGGRDCSGTLLDSKNCTDGLCVLNQRTLNDPKSHPLETSGDVALYAGLVVAVFVVVAVLMAV 394

  Fly   524 GTALICCARRGIRT-NPHYNMARSVMDADYMPGVVEKKEMRMHIEASNMGYDYVNPG--HRYLPG 585
            |   :...||..|. :.....:.:.:...:.|  |..|..|.:           ||.  |...|.
Mouse   395 G---VIVYRRNCRDFDTDITDSSAALTGGFHP--VNFKTARPN-----------NPQLLHPSAPP 443

  Fly   586 EHIMGMGIGCGGV---TEHHYDVPNLSANYTNPIDHLSVD-YLSET-GESS-------------- 631
            :.....||..|.|   .:....:|..::...:|:..|.:. |.|.| |..|              
Mouse   444 DLTASAGIYRGPVYALQDSADKIPMTNSPLLDPLPSLKIKVYNSSTIGSGSGLADGADLLGVLPP 508

  Fly   632 ---TADTSNSTFDMNGKLSILNAS---------KSSTYEMLGSAGGQLRLYGGELLLFVPEHAI- 683
               ..|.|..|..::.:.:.|.:.         .||.....|..||:|.|.|..:.|.||..|| 
Mouse   509 GTYPGDFSRDTHFLHLRSASLGSQHLLGLPRDPSSSVSGTFGCLGGRLSLPGTGVSLLVPNGAIP 573

  Fly   684 -GK------HVKKHVSLLLLSDECS-----RVSCATESSILCSSVVHSAPRNYSFVKPVILKIPH 736
             ||      |:.|..|.|.||:...     .|:|.....:||              :||:|.:||
Mouse   574 QGKFYDLYLHINKAESTLPLSEGSQTVLSPSVTCGPTGLLLC--------------RPVVLTVPH 624

  Fly   737 CL-VAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVA 800
            |. |....|   |:...::..:  .:|...|::.|||:|||.:.||||....|:.:|||.:..:.
Mouse   625 CAEVIAGDW---IFQLKTQAHQ--GHWEEVVTLDEETLNTPCYCQLEAKSCHILLDQLGTYVFMG 684

  Fly   801 EPRIQQPSIKMKLLAFSQHTPPSNANC-----SLRIYVVKDFPNSRDICANVEAKLGGSFLGESQ 860
            |...:....:::|..|:.      |.|     |||:|.::|.|.:......:|..|||..:.|.:
Mouse   685 ESYSRSAVKRLQLAIFAP------ALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPK 743

  Fly   861 VFAFTLNSRNLNIRVRSADVEAA-------APYEHAIPYQHILSNNS-ILHCEFSLRRQDQNS-- 915
            ...|..:..||.:.:.  |:..|       |.|:. ||:.|:.:.:. .|||.|:|.|....|  
Mouse   744 PLLFKDSYHNLRLSLH--DIPHAHWRSKLLAKYQE-IPFYHVWNGSQRALHCTFTLERHSLASTE 805

  Fly   916 ----LCVDFGQGSEDDYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHA 976
                :||...:|....:......|.:.:||.:.|.|.....|: .:.|.|.        .::|.:
Mouse   806 FTCKVCVRQVEGEGQIFQLHTTLAETPAGSLDALCSAPGNAIT-TQLGPYA--------FKIPLS 861

  Fly   977 TKRLICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVS 1041
            .::.||.:||.|.:...||||||:||:.|||:.|||||||||..||:|||.|.......:|    
Mouse   862 IRQKICSSLDAPNSRGNDWRLLAQKLSMDRYLNYFATKASPTGVILDLWEARQQDDGDLNS---- 922

  Fly  1042 HTIMALLLTLKEMGRQDVL 1060
                 |...|:|||:.::|
Mouse   923 -----LASALEEMGKSEML 936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-5NP_611033.2 Ig 236..321 CDD:472250 29/85 (34%)
Ig strand B 249..253 CDD:409389 1/3 (33%)
Ig strand C 263..267 CDD:409389 0/3 (0%)
Ig strand E 286..290 CDD:409389 1/4 (25%)
Ig strand F 300..305 CDD:409389 3/4 (75%)
Ig strand G 314..317 CDD:409389 1/2 (50%)
TSP1 327..379 CDD:214559 26/56 (46%)
TSP1 401..>422 CDD:214559 11/20 (55%)
ZU5 656..752 CDD:470600 32/109 (29%)
UPA 810..915 CDD:465384 31/117 (26%)
Death_UNC5-like 973..1064 CDD:260051 39/88 (44%)
Unc5bNP_084046.2 Ig 157..243 CDD:472250 29/85 (34%)
Ig strand B 170..174 CDD:409353 1/3 (33%)
Ig strand C 184..188 CDD:409353 0/3 (0%)
Ig strand E 208..212 CDD:409353 1/3 (33%)
Ig strand F 222..227 CDD:409353 3/4 (75%)
Ig strand G 236..239 CDD:409353 1/2 (50%)
TSP1 249..300 CDD:214559 26/56 (46%)
TSP1 305..353 CDD:214559 19/96 (20%)
ZU5 541..644 CDD:128514 34/121 (28%)
UPA domain. /evidence=ECO:0000250 689..838 38/157 (24%)
UPA 691..830 CDD:465384 35/147 (24%)
Interaction with DCC. /evidence=ECO:0000250|UniProtKB:O08722 707..725 6/17 (35%)
Death_UNC5B 858..941 CDD:176780 39/88 (44%)

Return to query results.
Submit another query.