DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-5 and Unc5a

DIOPT Version :10

Sequence 1:NP_611033.2 Gene:unc-5 / 36703 FlyBaseID:FBgn0034013 Length:1072 Species:Drosophila melanogaster
Sequence 2:XP_006517100.2 Gene:Unc5a / 107448 MGIID:894682 Length:1073 Species:Mus musculus


Alignment Length:1037 Identity:293/1037 - (28%)
Similarity:443/1037 - (42%) Gaps:207/1037 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 RPQQGSSSSGLGSSGAAGGS----------------------GILLEEFNSGKLS---------- 119
            ||:.|.|:..|.:|....|.                      ||:|..:..|..:          
Mouse   145 RPEVGLSAEALTASLPPAGPLVQPARPPAAMAVRPGLWPALLGIVLTAWLRGSGAQQSATVANPV 209

  Fly   120 PGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGS--SQPPPSTHETHVDPHTGV 182
            ||...:.||.||:|||.|::|||:|.:|.|||..:.|:.|||:|.  .|.......:......|:
Mouse   210 PGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSAGL 274

  Fly   183 NMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGS 247
            ...||...:.|..|::.||...:.|:|.||||.|..|||.|.:.|||:||:|.|.|.:..:.|..
Mouse   275 PTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQ 339

  Fly   248 RAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVS-AGTLIFRQVALQHMANYSCSAENIAGR 311
            ...|.|.||.|.|..::.|.:|..::....:|.:.:: ..:|:.||..|...|||:|.|:||..|
Mouse   340 GIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR 404

  Fly   312 RVSDSAVLIVYVNGGWSTWSPWRECKCAGKPSQGR---KRSRTCNNPMPLNGGAQCPGPQIQKSA 373
            |.|.||.:|||||||||||:.|..|..    |.||   ||||:|.||.||||||.|.|..:||:|
Mouse   405 RRSASAAVIVYVNGGWSTWTEWSVCSA----SCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTA 465

  Fly   374 DCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAG 438
            ....||.|                 ..||.||.||.|..:|...|.|:|                
Mouse   466 CATLCPVD-----------------GSWSPWSKWSACGLDCTHWRSREC---------------- 497

  Fly   439 DLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQC---QI 500
                                             ||..|..|...|.|.|:.|..|..:.|   ..
Mouse   498 ---------------------------------SDPAPRNGGEECRGADLDTRNCTSDLCLHTSS 529

  Fly   501 GKDDFDWTLYLGLAFITAVC---FAFGTALICCARR-GIRTNPHYNMARSVMDADYMP-GVVEKK 560
            |.:|.  .||:||..: |||   ......||.|.:: |:.::.   ...|::.:.:.| .:...|
Mouse   530 GPEDV--ALYIGLVAV-AVCLILLLLVLVLIYCRKKEGLDSDV---ADSSILTSGFQPVSIKPSK 588

  Fly   561 EMRMHI-----EASNMGYDYV--------NPGHRY-LPGEHIMGMGIGCGGVTEHHYDVPNLSAN 611
            ....|:     :.|.....|.        .|..:: |...|::. .:|.|..|.||         
Mouse   589 ADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLSNGHLLS-PLGSGRHTLHH--------- 643

  Fly   612 YTNPIDHLSVDYLSETGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLL 676
                        .|.|.|:....:..||  .|...|:...:.:..|......||:|.:....:.|
Mouse   644 ------------SSPTSEAEDFVSRLST--QNYFRSLPRGTSNMAYGTFNFLGGRLMIPNTGISL 694

  Fly   677 FVPEHAIGKHVKKHVSLLLLSDECSRV---SCATESSILCSSVVHSAPRNYSFVKPVILKIPHC- 737
            .:|..||.:.....:.|.|...|..|:   .|.|    |.|.:|...|......:||||.:.|| 
Mouse   695 LIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQT----LLSPIVSCGPPGVLLTRPVILAMDHCG 755

  Fly   738 LVAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEP 802
            ..:|:.|.:.:.....|.     :|...:.:|||:.:...:.||||...::.|||||.|.:|.|.
Mouse   756 EPSPDSWSLRLKKQSCEG-----SWEDVLHLGEESPSHLYYCQLEAGACYVFTEQLGRFALVGEA 815

  Fly   803 RIQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLN 867
            .....:.:::||.|:. ...::...::|:|.:.|..::......:|.:|||..:.|.:|..|..:
Mouse   816 LSVAATKRLRLLLFAP-VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDS 879

  Fly   868 SRNLNIRVRSADVEAA-------APYEHAIPYQHILS-NNSILHCEFSLRRQDQNS---LCVDFG 921
            ..||.:.:.  ||.::       ..|:. ||:.||.: ....|||.|:|.|.:.::   .|..:.
Mouse   880 YHNLRLSIH--DVPSSLWKSKLLVSYQE-IPFYHIWNGTQQYLHCTFTLERVNASTSDLACKVWV 941

  Fly   922 QGSEDDYYTFNIPAHSMSGS--AEELASTTNTTISIDRQGN---YVNESCVMDFVQLPHATKRLI 981
            ...|.|..:|||..:....:  ||.||        ::.:|.   .|..|.    .::|...::.|
Mouse   942 WQVEGDGQSFNINFNITKDTRFAEMLA--------LESEGGVPALVGPSA----FKIPFLIRQKI 994

  Fly   982 CGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECR--ANSSPGSSSNSVS 1041
            ..:||||.:...|||.||:||:.|.::::||:|.|||..||||||.|  .|.:.|..:.:|:
Mouse   995 ITSLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLGQLAAAVA 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-5NP_611033.2 Ig 236..321 CDD:472250 28/85 (33%)
Ig strand B 249..253 CDD:409389 1/3 (33%)
Ig strand C 263..267 CDD:409389 0/3 (0%)
Ig strand E 286..290 CDD:409389 1/3 (33%)
Ig strand F 300..305 CDD:409389 3/4 (75%)
Ig strand G 314..317 CDD:409389 1/2 (50%)
TSP1 327..379 CDD:214559 27/54 (50%)
TSP1 401..>422 CDD:214559 10/20 (50%)
ZU5 656..752 CDD:470600 26/99 (26%)
UPA 810..915 CDD:465384 28/112 (25%)
Death_UNC5-like 973..1064 CDD:260051 30/71 (42%)
Unc5aXP_006517100.2 Ig 328..414 CDD:472250 28/85 (33%)
Ig strand B 341..345 CDD:409353 1/3 (33%)
Ig strand C 355..359 CDD:409353 0/3 (0%)
Ig strand E 379..383 CDD:409353 1/3 (33%)
Ig strand F 393..398 CDD:409353 3/4 (75%)
Ig strand G 407..410 CDD:409353 1/2 (50%)
TSP1 420..471 CDD:214559 27/54 (50%)
TSP1 476..524 CDD:214559 20/96 (21%)
ZU5 670..773 CDD:128514 26/106 (25%)
UPA 820..957 CDD:465384 34/140 (24%)
Death_UNC5A 986..1069 CDD:260065 30/71 (42%)

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