Protein Alignment unc-5 and unc5a

DIOPT Version :9

• Sequence 1: NP_001286450.1
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_031753613.1
• Gene: unc5a / 100492616
• XenbaseID: XB-GENE-923412
• Length: 921
• Species: Xenopus tropicalis
• Alignment Length: 1040
• Identity: 290/1040 - (27%)
• Similarity: 439/1040 - (42%)
• Gaps: 242/1040 - (23%)

  Fly    88 PQQGSSSSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKAS 152
            |..||:|.|                        |:....||.||||||||::|||:|..|.|||:
 Frog    48 PMPGSASMG------------------------GQGGELLPHFLIEPESVYIVKNKPVTLNCKAT 88

  Fly   153 HSLQVIFKCSGSSQPPPSTHET-HVDPH-----TGVNMEEVTATIHRDLVDEFFGDGPFKCECHA 211
            .:.|:.|||:|.     ..|:| ||..|     ||:.:.||...|.|..|::.||...:.|.|.|
 Frog    89 PATQIYFKCNGE-----WVHQTDHVIQHSADRSTGLPVMEVRIDISRQQVEKIFGMDEYWCHCVA 148

  Fly   212 WSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITAD 276
            |||.|..|||.|.|.|||:||:|.|.|.|..:.|.....|.|:||.|.|..::.|.||..::..:
 Frog   149 WSSSGTSKSQKAFVRIAYLRKNFEQEPLSREVSLDQEVMLLCQPPEGIPPAEVEWLKNEEILDPE 213

  Fly   277 SEPGITV-SAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWRECK-CA 339
            .:..|.: |..:|:.||..|....||:|.|:||..||.|:||.:.||||||||:|:.|..|. ..
 Frog   214 VDSNIFIGSDNSLLLRQARLADTGNYTCVAKNIVARRRSNSAAITVYVNGGWSSWADWSPCSTTC 278

  Fly   340 GKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAW 404
            |:..|  ||||:|.||.|||||:.|.|..|||:|....||            :|..     |:.|
 Frog   279 GRGWQ--KRSRSCTNPTPLNGGSFCEGQNIQKTACTTLCP------------VSGG-----WAEW 324

  Fly   405 SDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATG 469
            |.||.|:::|...|.|.|     ||                                  |:
 Frog   325 SYWSACASDCTHWRSRDC-----TQ----------------------------------PA---- 346

  Fly   470 SSSDIIPGYGKSLCAGKDIQTAECRGEQC---------------QIGKDDFDWTLYLGLAFITA- 518
                  |..|...|.|.|::|..|..|.|               .:|..: |..||:|:..:..
 Frog   347 ------PRNGGPQCQGPDMETRNCTSELCINTLIMPFNTVKSNIAVGAPE-DVALYVGVVAVAVF 404

  Fly   519 VCFAFGTALICCARR-GIRTNPHYNMARSVMDADYMP--------GVVEKKEMRMHIEASNMGYD 574
            |.......|:|..|: |:..:.   ...|::.|.:.|        |......::..:..:.|.|.
 Frog   405 VVLLLAVILVCWRRKEGLDADV---ADSSILTAAFQPVSLKPGKAGQAHLLTIQPDLSTATMTYQ 466

  Fly   575 -------------YVNPGHRYLPGEHIMGMGIGCGGVTEHHYDVPNLSANYTNPIDHLSVDYLSE 626
                         .:..||...|    ||.||    ..||.:.:|.||..          .|..
 Frog   467 GSLCLRQDGGNKFQLTNGHLLSP----MGPGI----PREHSHTLPRLSTQ----------SYYR- 512

  Fly   627 TGESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHV 691
                                ::...|.:..|......||:||:....|.|.:|..||.:.....:
 Frog   513 --------------------TLPRGSNNMAYGTFNFLGGRLRIPNTGLSLLIPPDAIPRGKIYEI 557

  Fly   692 SLLLLSDECSRV---SCATESSILCSSVVHSAPRNYSFVKPVILKIPHCLVAP--EQWHVHIYHA 751
            .|.|...|..|:   .|.|    |...::...|......:||::.:.|| |.|  |.|.|.:...
 Frog   558 YLTLHKQEDVRLPLAGCQT----LLGPIISCGPPGVLLTQPVVVVMDHC-VEPSLENWTVRLKKQ 617

  Fly   752 DSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLLAF 816
            ..|.     :|...:.:...:.:...:..||:...::.|||||.|.:|.|......:.::|||.|
 Frog   618 SCEG-----SWEDVLQLDGGSPSHHYYCHLESRRCYLFTEQLGRFALVGESLSMSATKRLKLLLF 677

  Fly   817 SQHTPP--SNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSAD 879
            :   ||  :....|:|:|.:.|..::.....:.|.:.||..:.|.::..|..:..||.:.|.  |
 Frog   678 A---PPCCTTLEYSMRVYCINDTQDAIKEVIHHEKQQGGQLMDEPRLLHFKDSYHNLRLSVH--D 737

  Fly   880 VEAA-------APYEHAIPYQHILS-NNSILHCEFSLRRQDQNS---LCVDFGQGSEDDYYTFNI 933
            :.:.       |.|:. ||:.||.: ::..|||.|:|.|...::   .|..:....|.|..:|||
 Frog   738 MHSTQWKSKLLASYQE-IPFYHIWNGSHQNLHCTFTLERFSLSTWDLSCRIWMWQVEGDGQSFNI 801

  Fly   934 PAHSMSGSAEELASTTNTTISIDRQGNYVNESCVM---DFVQLPHATKRLICGALDPPRADERDW 995
               :::.|.|...|    .||:: :|.  .|:..:   :..::|...::.|..:||.|.:...||
 Frog   802 ---NVNLSKEHRPS----EISLE-EGE--KEAAALVGPNAFKIPFLMRQKIITSLDEPSSHGADW 856

  Fly   996 RLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGRQDVL 1060
            |:||:|||.|.::.:|.:|:|||..:||.||         :.|..:..:..|...:.|:|:||.|
 Frog   857 RILAQKLNLDSHLGFFISKSSPTAILLNFWE---------AQNFPNGNLTQLAAVVAEIGKQDSL 912

  Fly  1061  1060
             Frog   913  912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	31/88 (35%)
		Ig	236..321	CDD:299845	30/85 (35%)
		TSP1	327..379	CDD:214559	25/52 (48%)
		TSP1	401..>422	CDD:214559	9/20 (45%)
		ZU5	655..749	CDD:295340	27/98 (28%)
		Death_UNC5-like	973..1064	CDD:260051	30/88 (34%)
unc5a	XP_031753613.1	Ig	173..259	CDD:416386	30/85 (35%)
		Ig strand A'	177..181	CDD:409353	1/3 (33%)
		Ig strand B	185..192	CDD:409353	2/6 (33%)
		Ig strand C	200..205	CDD:409353	1/4 (25%)
		Ig strand C'	207..210	CDD:409353	0/2 (0%)
		Ig strand D	217..221	CDD:409353	1/3 (33%)
		Ig strand E	224..230	CDD:409353	1/5 (20%)
		Ig strand F	237..245	CDD:409353	4/7 (57%)
		Ig strand G	248..259	CDD:409353	5/10 (50%)
		TSP1	265..316	CDD:214559	25/52 (48%)
		TSP1_spondin	315..369	CDD:408798	24/119 (20%)
		ZU5	518..621	CDD:128514	28/107 (26%)
		UPA	668..807	CDD:407337	37/147 (25%)
		DD	834..917	CDD:417479	30/88 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7329
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1941
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm49043
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060