DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-5 and unc5b

DIOPT Version :9

Sequence 1:NP_001286450.1 Gene:unc-5 / 36703 FlyBaseID:FBgn0034013 Length:1072 Species:Drosophila melanogaster
Sequence 2:XP_002939005.3 Gene:unc5b / 100492290 XenbaseID:XB-GENE-6046963 Length:943 Species:Xenopus tropicalis


Alignment Length:1048 Identity:298/1048 - (28%)
Similarity:459/1048 - (43%) Gaps:216/1048 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 AAG--GSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGS 164
            |||  .|.:|.:.|      |...:.:||.||:|||..::|||:|..|.|||:.:.|:.|||:|.
 Frog    29 AAGIEYSDVLPDSF------PSAPAESLPHFLLEPEDAYIVKNKPVELVCKANPATQIYFKCNGE 87

  Fly   165 --SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHI 227
              :|....|.| .||..||:.:.||...:.|..|:|.||...:.|:|.||||.|..||:.|.|.|
 Frog    88 WVNQNDHITKE-RVDEVTGLVVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSKRAYVRI 151

  Fly   228 AYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVI--TADSEPGITVSAGTLIF 290
            ||:||:|:|.|....:.|...|.|:|.||.|.|..::.|.||..:|  |.|:...||:. ..||.
 Frog   152 AYLRKNFDQEPLGKEVALEQEALLQCRPPEGVPPAEVEWLKNEEIIDPTKDTNFLITID-HNLII 215

  Fly   291 RQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWREC--KCAGKPSQG-RKRSRTC 352
            :|..|...|||:|.|:||..:|.|.:|.:||:||||||:|:.|..|  :|    ..| :||:|||
 Frog   216 KQARLSDTANYTCVAKNIVAKRRSTTATVIVFVNGGWSSWTEWSPCNNRC----GHGWQKRTRTC 276

  Fly   353 NNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQV 417
            .||.|||||..|.|.|.||.|....||.|                 ..|:.||.||.||.||...
 Frog   277 TNPAPLNGGTMCEGQQYQKFACNTMCPVD-----------------GGWTEWSKWSACSTECTHW 324

  Fly   418 RRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYGKSL 482
            |.|:|                                       .:|:...|         ||. 
 Frog   325 RSREC---------------------------------------NAPTPKNG---------GKD- 340

  Fly   483 CAGKDIQTAECRGEQCQIGK------------DDFDWTLYLGL--AFITAVCFAFGTALICCARR 533
            |:|..:.:..|....|...|            ...|..||.||  |....:.......::...|.
 Frog   341 CSGMLLDSKNCTDGLCMQNKRVLGETKSHLLESTGDVALYAGLVVAIFIVIILLMAVGIVVYRRN 405

  Fly   534 GIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIEASNMGYDYVNP----------GHRYLPGEHI 588
            ....:.....:.:.:...:.|  |..|..| | :.|::.:..:.|          ||.|      
 Frog   406 CRELDTDITDSSAALTGGFHP--VNFKTSR-H-DNSHLIHPAMQPDLTANAGIYRGHMY------ 460

  Fly   589 MGMGIGCGGVTEHHYDVPNLSANYTNPIDHLSVDYLSETGESSTADTSNSTFDMNGKL------- 646
                    .:.:....:|..::...:|:.:|.:...:    |||..:|....|.|..|       
 Frog   461 --------ALQDSADKIPMTNSPLLDPLPNLKIKVFN----SSTVGSSPGIHDGNDLLGVKPTGT 513

  Fly   647 -----SILNA----------------SKSSTYEMLGSAGGQLRLYGGELLLFVPEHAI--GKHVK 688
                 :|:||                |.:|.....||.||:|......:.|.:|:.||  ||:.:
 Frog   514 YPSDNNIMNARNKNMSTQHLLTLPRDSSNSVTGTFGSLGGRLTFPNTGVSLLIPQGAIPQGKYYE 578

  Fly   689 KHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCL-VAPEQWHVHIYHAD 752
            .:   |:::...:.|..:..:..:.|.::...|......|||||.:|||. :|...|.:.:  ..
 Frog   579 MY---LMINKRENTVLPSEGTQTILSPIITCGPTGLLLCKPVILTVPHCADIATSDWILQL--KT 638

  Fly   753 SEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLLAFS 817
            ..|..   ||...|::.|||:|||.:.|||:....|:.:|||.:..|.|...:....:::|..|:
 Frog   639 QSHQG---NWEEVVTLNEETLNTPCYCQLESHSCHILLDQLGTYAFVGESYSKSAVKRLQLAIFA 700

  Fly   818 QHTPP---SNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSAD 879
                |   ::...:|::|.|:|.|::......:|..|||..:.:.:...|..:..||.:.:.  |
 Frog   701 ----PMLCTSLEYNLKVYCVEDTPDALKEVLELEKTLGGYLVEDPKPLMFKDSYHNLRLSIH--D 759

  Fly   880 V-------EAAAPYEHAIPYQHILSNNS-ILHCEFSLRRQDQNS------LCVDFGQGSEDDYYT 930
            :       :..|.|:. ||:.||.|.:. .|||.|:|.|....:      :||...:| |...:.
 Frog   760 IPHSLWRSKLLAKYQE-IPFYHIWSGSQRTLHCTFTLERYSLAATELTCKICVRQVEG-EGQIFQ 822

  Fly   931 FNIPAHSMSGSAEELASTTNTTISIDRQGNYVNESCVMDFVQLPHATKRLICGALDPPRADERDW 995
            .:........|.:...|.|..::: .:.|.|.        .::|::.::.||.:||.|.:...||
 Frog   823 LHTSLEENVKSFDPFCSHTENSVT-TQLGPYA--------FKIPYSIRQKICNSLDAPNSRGNDW 878

  Fly   996 RLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGRQDVL 1060
            ||||:||..|||:.|||||||||..||:|||. .:...|.        :..|...|:|||:.:::
 Frog   879 RLLAQKLCMDRYLNYFATKASPTGVILDLWEA-LHQDDGD--------LNTLASALEEMGKSEMM 934

  Fly  1061 DIIVETIG 1068
             :::.|.|
 Frog   935 -LVMATDG 941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-5NP_001286450.1 I-set 233..321 CDD:254352 33/89 (37%)
Ig 236..321 CDD:299845 32/86 (37%)
TSP1 327..379 CDD:214559 25/54 (46%)
TSP1 401..>422 CDD:214559 11/20 (55%)
ZU5 655..749 CDD:295340 26/96 (27%)
Death_UNC5-like 973..1064 CDD:260051 37/90 (41%)
unc5bXP_002939005.3 Ig 160..246 CDD:416386 32/86 (37%)
Ig strand A' 164..168 CDD:409353 0/3 (0%)
Ig strand B 172..179 CDD:409353 3/6 (50%)
Ig strand C 187..192 CDD:409353 1/4 (25%)
Ig strand C' 194..197 CDD:409353 0/2 (0%)
Ig strand D 206..209 CDD:409353 1/2 (50%)
Ig strand E 211..217 CDD:409353 2/5 (40%)
Ig strand F 224..232 CDD:409353 5/7 (71%)
Ig strand G 235..246 CDD:409353 3/10 (30%)
TSP1 252..300 CDD:214559 25/51 (49%)
TSP1 308..356 CDD:214559 19/96 (20%)
ZU5 540..643 CDD:128514 28/107 (26%)
UPA 690..829 CDD:407337 33/146 (23%)
Death_UNC5B 856..939 CDD:176780 37/92 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 94 1.000 Domainoid score I7329
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 392 1.000 Inparanoid score I1941
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D169564at33208
OrthoFinder 1 1.000 - - FOG0000918
OrthoInspector 1 1.000 - - otm49043
Panther 1 1.100 - - O PTHR12582
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X496
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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