Protein Alignment unc-5 and unc5c

DIOPT Version :9

• Sequence 1: NP_001286450.1
• Gene: unc-5 / 36703
• FlyBaseID: FBgn0034013
• Length: 1072
• Species: Drosophila melanogaster
• Sequence 2: XP_004911160.2
• Gene: unc5c / 100485730
• XenbaseID: XB-GENE-921628
• Length: 951
• Species: Xenopus tropicalis
• Alignment Length: 1061
• Identity: 307/1061 - (28%)
• Similarity: 449/1061 - (42%)
• Gaps: 218/1061 - (20%)

  Fly    96 GLGSSGAAGGSGILLEEFNSGKLS-----------------------PGEASNTLPIFLIEPESV 137
            |:.::....|.|.:|:.|....|:                       |.:....||.||||||..
 Frog     4 GMETASCGVGLGCILQLFFLPALAILSAGSTLAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEA 68

  Fly   138 FVVKNRPAVLKCKASHSLQVIFKCSGS--SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFF 200
            ::|||:|..|.||||.:.|:.|||:..  .|.....:| .||..:|:.:.||:..|.|..|:|.|
 Frog    69 YIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVNE-KVDETSGLIVREVSIEISRQQVEELF 132

  Fly   201 GDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLT 265
            |...:.|:|.||||.|..||:.|.|.|||:||:|.|.|....:.|.....|:|.||.|.|..::.
 Frog   133 GLEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPGAEVE 197

  Fly   266 WHKNNAVI--TADSEPGITVSAGTLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWS 328
            |.||..||  ..|....||:. ..||.:|..|...|||:|.|:||.|:|.|.:|.:|||||||||
 Frog   198 WLKNEDVIDPVEDRNFYITID-HNLIIKQARLSDTANYTCVAKNIVGKRRSTTATVIVYVNGGWS 261

  Fly   329 TWSPWREC--KCAGKPSQGRKRSRTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFD 391
            ||:.|..|  :| ||..|  ||:|||.||.|||||..|.|..:||.|..:.||||
 Frog   262 TWTEWSACSNRC-GKGYQ--KRTRTCTNPAPLNGGYICEGQGVQKMACTSLCPED---------- 313

  Fly   392 ISSSKRMARWSAWSDWSICSAECIQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAA 456
                   ..|:|||.||.|..||...|||.|
 Frog   314 -------GEWTAWSKWSTCGTECTHWRRRDC---------------------------------- 337

  Fly   457 GVGAVGSPSEATGSSSDIIPGYGKSLCAGKDIQTAECRGEQCQIG--------------KDDFDW 507
                 .:|....|         ||. |.|..:|:..|....|..|              :.::::
 Frog   338 -----ANPPPRNG---------GKD-CDGPVLQSKNCTDGLCMQGLIYPHSPRIHEQKTQKEYEY 387

  Fly   508 T---------LYLGLAFITAVCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKKEMR 563
            :         ||:|:.....||.|....:.....|    ..|......::|...:.|..:    .
 Frog   388 SSAPSSDNVALYVGIVIAVIVCLAISVIVALFVYR----KNHRGFESDIIDTSALNGGFQ----A 444

  Fly   564 MHIEASNMGYDYVNPGHRYLPGEHIMGMGIGCGGVTEHHYDV---------------PNL----- 608
            ::|:|:..  |.:.     :|.:......:..|.|...| ||               |||
 Frog   445 VNIKAARQ--DLLG-----VPPDLTSAAAMYRGPVYALH-DVSDKIPMTNSPLLDPLPNLKIKVY 501

  Fly   609 -SANYTNPIDHLSVDYLSETGESSTAD-TSNSTFDM-NGKLSILNASKSSTYEMLGSAGGQLRLY 670
             |:....|.|.|| ||.|:.....|.. ..|.|.:| |..|:.......:.:....|.||.|.:.
 Frog   502 NSSGTVTPQDDLS-DYTSKLSSQITQSLLENDTLNMKNQSLARQTDPSCTAFGTFNSLGGHLIIP 565

  Fly   671 GGELLLFVPEHAI--GKHVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILK 733
            ...:.|.:|..|:  |:..:.:|::....:....:.   :|..|.:.||...|......:||||.
 Frog   566 NSGVSLLIPAGAVPQGRVYEMYVTVHRKENMRPPIE---DSQTLLTPVVSCGPPGALMTRPVILT 627

  Fly   734 IPHCL-VAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFT 797
            :.||. ...|.|.:.:     :...:...|...|.||||...||.::|:|:....|:||.|..:.
 Frog   628 MHHCAETTAEDWKMQL-----KEQSVQGQWEDVVFVGEENFTTPCYIQMESEACHILTETLSTYA 687

  Fly   798 VVAEPRIQQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVF 862
            :|.:...:..:.::||..|.. |..::...::|:|.:.|..::.......|.|:||..|.|.:..
 Frog   688 LVGQSTSKSSAKRLKLALFGP-TSCTSLEYNIRVYCLDDTQDALKEVIQQERKVGGQLLDEPKTL 751

  Fly   863 AFTLNSRNLNIRVRSADV-------EAAAPYEHAIPYQHILSN-NSILHCEFSLRRQDQNS---- 915
            .|..::.||.:.:.  ||       :..|.|:. ||:.||.|. ...|||.|:|.|...::
 Frog   752 HFKGSTHNLRLSIH--DVPHSLWKSKLLAKYQE-IPFYHIWSGCQRNLHCTFTLERFSLSTVELV 813

  Fly   916 --LCVDFGQGSEDDYYTFNIPAHSMSGSAEEL----ASTTNTTISIDRQGNYVNESCVMDFVQLP 974
              |||...:| |...:..|..|.....|..:|    :::|.|||        |..|.    ..:|
 Frog   814 CKLCVRQVEG-EGQIFQLNCTASEEPSSIIDLPLMDSASTITTI--------VGPSA----FSIP 865

  Fly   975 HATKRLICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLWECRANSSPGSSSNS 1039
            ...::.:|.:||.|:....|||:||.||..|||:.|||||.|||..||:|||.: |...|:.|
 Frog   866 LTIRQKLCSSLDAPQTRGHDWRMLAHKLKLDRYLNYFATKPSPTGVILDLWEAQ-NYPEGNLS-- 927

  Fly  1040 VSHTIMALLLTLKEMGRQDVL 1060
                  .|...|:||||.:.:
 Frog   928 ------TLAAVLEEMGRHETM 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	33/89 (37%)
		Ig	236..321	CDD:299845	32/86 (37%)
		TSP1	327..379	CDD:214559	27/53 (51%)
		TSP1	401..>422	CDD:214559	12/20 (60%)
		ZU5	655..749	CDD:295340	22/96 (23%)
		Death_UNC5-like	973..1064	CDD:260051	37/88 (42%)
unc5c	XP_004911160.2	Ig	168..254	CDD:416386	32/86 (37%)
		Ig strand A'	172..176	CDD:409353	0/3 (0%)
		Ig strand B	180..187	CDD:409353	2/6 (33%)
		Ig strand C	195..200	CDD:409353	1/4 (25%)
		Ig strand C'	202..205	CDD:409353	0/2 (0%)
		Ig strand D	211..216	CDD:409353	0/4 (0%)
		Ig strand E	219..225	CDD:409353	2/5 (40%)
		Ig strand F	232..240	CDD:409353	5/7 (71%)
		Ig strand G	243..254	CDD:409353	4/10 (40%)
		TSP1	260..311	CDD:214559	27/53 (51%)
		TSP1	316..364	CDD:214559	21/96 (22%)
		ZU5	547..650	CDD:128514	22/110 (20%)
		UPA	698..836	CDD:407337	38/142 (27%)
		DD	864..946	CDD:417479	37/88 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7329
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2765
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1941
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm49043
Panther	1	1.100	-	-	LDO	PTHR12582
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160