DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-5 and unc5db

DIOPT Version :9

Sequence 1:	NP_001286450.1	Gene:	unc-5 / 36703	FlyBaseID:	FBgn0034013	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	XP_001342230.2	Gene:	unc5db / 100002445	ZFINID:	ZDB-GENE-060531-162	Length:	941	Species:	Danio rerio

Alignment Length:	1028	Identity:	279/1028 - (27%)
Similarity:	423/1028 - (41%)	Gaps:	203/1028 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVI 158
            :||.|..|.|     |.:..:|       ...|||.||.|||..:::||.|..|:|:|:.:||:.
Zfish    33 ASGRGPVGDA-----LADSLSS-------VGGTLPHFLQEPEDAYIIKNNPIKLRCRATPALQIF 85

  Fly   159 FKCSGS--SQPPPSTHETHVDPHTGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQ 221
            |||:|.  .|...|:.| ::|.:|||.:.|||..:.|..|::|.|...:.|.|.|||..|..||:
Zfish    86 FKCNGEWVHQNQHSSQE-YMDQNTGVKIREVTINVTRQQVEDFHGPEDYWCLCVAWSHLGTSKSR 149

  Fly   222 AATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG 286
            .|||.|||:||:|.|.|....:.:.....|.|.||.|.|..|:.|.||..:::|..:..|...|.
Zfish   150 RATVRIAYLRKNFEQDPQGKEVPIKGMIVLHCRPPEGVPMAKVEWLKNEELVSALEDDNIDTRAD 214

  Fly   287 -TLIFRQVALQHMANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWRECKC-AGKPSQGRKRS 349
             .||..:..|...|||:|.|.||..:|.|.:|.::|:||||||.|:.|..|.. .|:..|  |||
Zfish   215 HNLIINEARLSDSANYTCLATNIVAKRRSTTATVVVFVNGGWSLWTEWSSCSVNCGRGVQ--KRS 277

  Fly   350 RTCNNPMPLNGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAEC 414
            |||.||.||||||.|.|..:||.|..|.||.|                 ..|..||:|::|||:|
Zfish   278 RTCTNPAPLNGGAFCEGMSVQKIACNAVCPVD-----------------GVWEEWSEWTMCSAQC 325

  Fly   415 IQVRRRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGYG 479
            .:.|.|:|                                                 :|..|.:.
Zfish   326 ERQRWREC-------------------------------------------------NDPPPRHR 341

  Fly   480 KSLCAGKDIQTAECRGEQC-QIGK-----------DDFDWTLYLGLAF-ITAVCFAFGTALICCA 531
            ..:|.|:...|..|.|..| |.||           :..|..||.|||. :.||     ..||...
Zfish   342 GKMCEGEGQSTENCTGGLCTQNGKLMHDVKPQSMENSMDVALYSGLAAGVIAV-----VVLIVAI 401

  Fly   532 RRGIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIEA------SNMGYDYVNPGHRY-------- 582
            ....::...|.:  .|:|:..:.|..:....:...:.      |:|..| :..|..|
Zfish   402 TLYRKSQSEYGV--DVIDSSALAGGFQSFNFKTTRQGNPLLLNSSMQPD-ITVGQTYSSPICFQD 463

  Fly   583 ---------LP------GEHIMGMGIGCGG---VTEHHYDVP-NLSANYTNPIDHLSVDYLSETG 628
                     ||      ...::.:|:....   |..|...:| ||..||            |...
Zfish   464 SIDKELFDPLPDKVKVQSSFMVSLGVADRAEYHVKAHPQTLPANLHPNY------------SMVE 516

  Fly   629 ESSTADTSNSTFDMNGKLSILNASKSSTYEMLGSAGGQLRLYGGELLLFVPEHAIGKHVKKHVSL 693
            ...||..:.:.....||:.:      .|..:.|..||:|.:....:.|.||..||.......:.:
Zfish   517 GKKTATMAPNGLHTPGKIQL------KTSAVFGHLGGRLVIPNAGVSLLVPHGAIADDTSWEMYM 575

  Fly   694 LLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVILKIPHCL-VAPEQWHVHIYHADSEHDE 757
            |:...|.|..| .....||....:...|...|...||.:.|.||. |:.|.|::.:.....::
Zfish   576 LINQGETSAQS-EERCEILLGPEITYGPPGLSLSCPVAMTIAHCAEVSAENWNIKLKRQTKDN-- 637

  Fly   758 LSVNWRRAVSVGEETINTPMFVQLEATHVFIMTEQLGHFTVVAEPRIQQPSIKMKLLAFSQHTPP 822
               .|...:||.:|  :|..:..:::....::.:|.|.:.:|.|| |...:||...:|.......
Zfish   638 ---KWEEIMSVDDE--STSCYCLMDSHSCHLLLDQPGCYALVGEP-ITDAAIKRLRIAVFGSMEA 696

  Fly   823 SNANCSLRIYVVKDFPNSRDICANVEAKLGGSFLGESQVFAFTLNSRNLNIRVRSADVE----AA 883
            |:.:.|||::.|.|.|::.......|...||..|.|.:...|..|..:|.:.::  |:.    :.
Zfish   697 SSLDYSLRVHCVDDTPHAFQGVVTAETCRGGQLLEEPKTLFFKGNCLSLQVSIQ--DIPQFLWSI 759

  Fly   884 APYEHAIPY---QHILSNNSILHCEFSLRRQDQNSLCVDFGQGSEDDYYTFNIPAHSMSGSAEEL 945
            .|:.....:   |...||...:||.|||:|           ..:..:..:..|....:.|..:.|
Zfish   760 KPFTTCQEFSFTQVWYSNQQPVHCAFSLQR-----------HSAATNQLSCKISVRQVKGHEQIL 813

  Fly   946 ASTTNT------TISIDRQGN-YVNESCVMDFVQLPHATKRLICGALDPPRADERDWRLLAKKLN 1003
            ...|:.      |:....|.: .|.........::|.:.::.||...|...|..:||:|||:||:
Zfish   814 QVYTSVGENEKETVPFFMQADCTVTSQTGAKAFKIPLSIRQRICTTFDTANAKGKDWQLLAQKLH 878

  Fly  1004 TDRYIAYFATKASPTEQILNLWECRANSSPGSSSNSVSHTIMALLLTLKEMGR 1056
            ..|.::||..:.||:..||:|||.|...|....|         |...|:|:|:
Zfish   879 IQRNLSYFTKQKSPSAVILSLWEARHQDSGDLDS---------LASALEEIGK 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-5	NP_001286450.1	I-set	233..321	CDD:254352	29/88 (33%)
		Ig	236..321	CDD:299845	28/85 (33%)
		TSP1	327..379	CDD:214559	27/52 (52%)
		TSP1	401..>422	CDD:214559	10/20 (50%)
		ZU5	655..749	CDD:295340	26/94 (28%)
		Death_UNC5-like	973..1064	CDD:260051	29/84 (35%)
unc5db	XP_001342230.2	I-set	162..250	CDD:254352	29/87 (33%)
		Ig	164..250	CDD:299845	28/85 (33%)
		TSP1	256..307	CDD:214559	27/52 (52%)
		TSP1	312..360	CDD:214559	18/96 (19%)
		ZU5	538..632	CDD:279170	26/94 (28%)
		DD	848..941	CDD:301326	29/84 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595331
Domainoid	1	1.000	65	1.000	Domainoid score	I10013
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2014
OMA	1	1.010	-	-		QHG45590
OrthoDB	1	1.010	-	-		D169564at33208
OrthoFinder	1	1.000	-	-		FOG0000918
OrthoInspector	1	1.000	-	-		otm25359
orthoMCL	1	0.900	-	-		OOG6_102612
Panther	1	1.100	-	-	O	PTHR12582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X496
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910