Protein Alignment Hr51 and NR2E1

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001273031.1
• Gene: NR2E1 / 7101
• HGNCID: 7973
• Length: 422
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 185/571 - (32%)
• Similarity: 267/571 - (46%)
• Gaps: 179/571 - (31%)

  Fly    27 PPPAPMHGQAPPPTSTGVAPPTQPPPPHPAAPNVPNGRLLSWNHSAAAAAAAAAAQAAANSMNHS 91
            |.|.|.....|.|   |:..|.....|.|:....|.||:|.
Human    13 PSPRPECRADPGP---GLGFPLGSGLPWPSLLESPGGRILD------------------------ 50

  Fly    92 SAAEGSSMTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGT-GRCV 155
                             :.|.||||.|||||||:.||:|||||||||:||...|.|::|. |.|.
Human    51 -----------------IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCP 98

  Fly   156 VDKAHRNQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETL-----REMEHGRALREAAVAV 215
            |||.|||||:||||||||::.|||||||:||.|| |:|||.:..     .:.|:|.|..
Human    99 VDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPR-TSTIRKQVALYFRGHKEENGAAAH------ 156

  Fly   216 GVFGPPVLLSPPCYGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHS 280
                         :.|..||.|:.             .|:..||
Human   157 -------------FPSAALPAPAF-------------FTAVTQL--------------------- 174

  Fly   281 PKEKAYGMEMATSGNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDD 345
               :.:|:|:|.                  .|..||..          :.||.:.||
Human   175 ---EPHGLELAA------------------VSTTPERQ----------TLVSLAQPT-------- 200

  Fly   346 SIDVTNDNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSF 410
                   .:.||.|:.:      |.:    ||....|:|.|::||||||::||||::|:|:.||.
Human   201 -------PKYPHEVNGT------PMY----LYEVATESVCESAARLLFMSIKWAKSVPAFSTLSL 248

  Fly   411 RDQVILLEESWSELFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKE--ELAADVR 473
            :||::|||::|.|||:|...||.||:|..  .|.:|        :..|||...:::  ::.::::
Human   249 QDQLMLLEDAWRELFVLGIAQWAIPVDAN--TLLAV--------SGMNGDNTDSQKLNKIISEIQ 303

  Fly   474 TLHEIFCKYKAVLVDPAEFACLKAIVLFR-------PETRGLKDPAQIENLQDQAHVMLSQHTKT 531
            .|.|:..:::.:.:|..||||||.||.|:       .|.|..::.|.|..|||:|.:.|:.:..|
Human   304 ALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHT 368

  Fly   532 QFTAQIARFGRLLLMLPLLRMISSHKIESIYFQRTIGNTPMEKVLCDMYKN 582
            ::..|..|||:|||:||.||.||...||.::|::||||.|:.::|.||||:
Human   369 RYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	58/91 (64%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	83/223 (37%)
NR2E1	NP_001273031.1	NR_DBD_TLX	45..136	CDD:143537	61/132 (46%)
		NR_LBD_Tlx_PNR_like	191..406	CDD:132748	87/259 (34%)