Protein Alignment Hr51 and NR2F1

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_005645.1
• Gene: NR2F1 / 7025
• HGNCID: 7975
• Length: 423
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 168/546 - (30%)
• Similarity: 218/546 - (39%)
• Gaps: 177/546 - (32%)

  Fly    34 GQAPPPTSTGVAPPTQPPPPHPAAPNVPNGRLLSWNHSAAAAAAAAAAQAAANSMNHSSAAEGSS 98
            |:......:| ||.|...|..|.||..|                     ..|..........|.|
Human    38 GEQQQQAGSG-APHTPQTPGQPGAPATP---------------------GTAGDKGQGPPGSGQS 80

  Fly    99 MTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQ 163
            ...|:       ||||||.|||||||...|.||..||||||||.|.|.|:|.. .|.:|:.||||
Human    81 QQHIE-------CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANR-NCPIDQHHRNQ 137

  Fly   164 CQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLSPPC 228
            ||.|||||||::||.::|||..|.|..........|..                 |.|  |:..|
Human   138 CQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN-----------------GDP--LNGHC 183

  Fly   229 YGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATS 293
            |.||.:                     |:.|.|
Human   184 YLSGYI---------------------SLLLRA-------------------------------- 195

  Fly   294 GNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHA 358
                                                                         ||:.
Human   196 -------------------------------------------------------------EPYP 199

  Fly   359 VSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSE 423
            .||..|     |.|.|| .....|.:.|.:|||||.||:||:|:|.|..|...|||.||..:|||
Human   200 TSRYGS-----QCMQPN-NIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258

  Fly   424 LFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVD 488
            ||:|||.|..:||. ....|.:...|.:.:    :.|..:.   ....:|...|...|.||:.||
Human   259 LFVLNAAQCSMPLH-VAPLLAAAGLHASPM----SADRVVA---FMDHIRIFQEQVEKLKALHVD 315

  Fly   489 PAEFACLKAIVLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMI 553
            .||::||||||||..:..||.|.|.||:||:::...|.::.::|:..|.:|||:|||.||.||.:
Human   316 SAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380

  Fly   554 SSHKIESIYFQRTIGNTPMEKVLCDM 579
            ||..||.::|.|.:|.||:|.::.||
Human   381 SSSVIEQLFFVRLVGKTPIETLIRDM 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	50/90 (56%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	87/214 (41%)
NR2F1	NP_005645.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		12/64 (19%)
		NR_DBD_COUP_TF	86..158	CDD:143516	47/72 (65%)
		NR_LBD_COUP-TF	184..419	CDD:132746	99/351 (28%)