DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr51 and RXRA

DIOPT Version :10

Sequence 1:NP_611032.2 Gene:Hr51 / 36702 FlyBaseID:FBgn0034012 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_002948.1 Gene:RXRA / 6256 HGNCID:10477 Length:462 Species:Homo sapiens


Alignment Length:608 Identity:164/608 - (26%)
Similarity:241/608 - (39%) Gaps:203/608 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NSSETRPSSQ-ELHSPQRHCYTPPPAPMHGQAPPPTST------GVAPP----TQPPPPHPAAPN 59
            |||.|.|:.: .:.:|..|....|.....||...|.||      |:.||    :.|..||  :.:
Human    16 NSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPH--SMS 78

  Fly    60 VPNGRLLSWNHSAAAAAAAAAAQAAANSMNHSSAAEGSSMTRIKGQNLGL--------------- 109
            ||....|.:         :..:...::.||..|::|.     || ..|||               
Human    79 VPTTPTLGF---------STGSPQLSSPMNPVSSSED-----IK-PPLGLNGVLKVPAHPSGNMA 128

  Fly   110 -----ICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRL 169
                 ||.:|||.|||||||:.:|.||.|||||:||:.|.|.|:.... |::||..||:||.||.
Human   129 SFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD-CLIDKRQRNRCQYCRY 192

  Fly   170 KKCLQMGMNKDAVQNERQ---PRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLSPPCYGS 231
            :|||.|||.::|||.|||   .||.        .|:|...:..|                     
Human   193 QKCLAMGMKREAVQEERQRGKDRNE--------NEVESTSSANE--------------------- 228

  Fly   232 GLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATSGNV 296
                     .:|..|:|       ..:||.                  .||.:.|          
Human   229 ---------DMPVERIL-------EAELAV------------------EPKTETY---------- 249

  Fly   297 SHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHAVSR 361
                 ..:|..::||||                            ||    .|||          
Human   250 -----VEANMGLNPSSP----------------------------ND----PVTN---------- 267

  Fly   362 SDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSELFL 426
                                  :.:.:.:.||..|:|||.:|.|:.|...||||||...|:||.:
Human   268 ----------------------ICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI 310

  Fly   427 LNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVDPAE 491
            .:.....|.:.........:..|.|:..:...|         |...|.|.|:..|.:.:.:|..|
Human   311 ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVG---------AIFDRVLTELVSKMRDMQMDKTE 366

  Fly   492 FACLKAIVLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSH 556
            ..||:|||||.|:::||.:||::|.|:::.:..|..:.|.::..|..||.:|||.||.||.|...
Human   367 LGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLK 431

  Fly   557 KIESIYFQRTIGNTPMEKVLCDM 579
            .:|.::|.:.||:||::..|.:|
Human   432 CLEHLFFFKLIGDTPIDTFLMEM 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr51NP_611032.2 NR_DBD_PNR 103..194 CDD:143528 52/113 (46%)
NR_LBD_Tlx_PNR_like 354..569 CDD:132748 59/214 (28%)
RXRANP_002948.1 Modulating. /evidence=ECO:0000250 1..134 31/134 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..107 26/106 (25%)
Nuc_recep-AF1 17..127 CDD:463363 30/126 (24%)
NR_DBD_RXR 133..209 CDD:143514 43/76 (57%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12145331 160..165 3/4 (75%)
Hinge 201..224 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..228 8/29 (28%)
NR_LBD_RXR_like 229..440 CDD:132741 76/323 (24%)
Required for nuclear export. /evidence=ECO:0000269|PubMed:15509776 348..368 6/19 (32%)

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