DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr51 and Nr2c2

DIOPT Version :9

Sequence 1:	NP_611032.2	Gene:	Hr51 / 36702	FlyBaseID:	FBgn0034012	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_038964192.1	Gene:	Nr2c2 / 50659	RGDID:	3201	Length:	629	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	160/527 - (30%)
Similarity:	251/527 - (47%)	Gaps:	90/527 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 EGSSMTRIKGQ------NLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGR 153
            :.:|:.|:.|:      .:...||||||.:||:|||.::|.||.||||||||:.|.|.|::...
  Rat   128 DSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQD- 191

  Fly   154 CVVDKAHRNQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVF 218
            |:::|.|||:||.|||||||:|||..::||:||:|.:....:|...           ||....::
  Rat   192 CIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNC-----------AASTEKIY 245

  Fly   219 GPPVLLSPPCYGSGLLPPPSL-----GSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAG-- 276
            ....|.||      |:..|:.     ||..|| ||....|.:..|           |:....|
  Rat   246 IRKDLRSP------LIATPTFVADKDGSRQTG-LLDPGMLVNIQQ-----------PLIREDGTV 292

  Fly   277 --VHHSPKEKAYGMEMATSGNV----SHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSV---- 331
              ...|..|.:.| .:.|..||    ::.:.|.:|.......|..::|.||..|..:::..
  Rat   293 LLATDSKAETSQG-ALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTT 356

  Fly   332 -SSSSPTMENDNDDDSIDVTNDNEEPHAVSRSDSSFI------------------MPQFMSPNLY 377
             |:|.|::.     |.||.:... ..|.:||..|:.|                  ||..|...|.
  Rat   357 DSASPPSLA-----DGIDASGGG-SIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLN 415

  Fly   378 THQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSELFLLNAIQWCIPLDPTGCA 442
            .|.   :.|:::||||:::.||:::|:|..|.......|:...|:|||.|...| |..:......
  Rat   416 VHY---ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ-CAQVMSLSTI 476

  Fly   443 LFSVAEHCNN--LENNANGDTCITKEELAADVRTLHEIFCKYKAVL-VDPAEFACLKAIVLFRPE 504
            |.::..|..|  .|:..:||..   :::...:..|.| ||...|.| :|..|:|.|||||||.|:
  Rat   477 LAAIVNHLQNSIQEDKLSGDRI---KQVMEHIWKLQE-FCNSMAKLDIDGYEYAYLKAIVLFSPD 537

  Fly   505 TRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSHKIESIYFQRTIGN 569
            ..||...:|||..|::|.:.|..:.:..::....|..|:|:.||.||::||:..|.::|...|||
  Rat   538 HPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGN 602

  Fly   570 TPMEKVL 576
            ..::.::
  Rat   603 VSIDSII 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	48/96 (50%)
Hr51	NP_611032.2	NR_LBD_Tlx_PNR_like	354..569	CDD:132748	71/235 (30%)
Nr2c2	XP_038964192.1	NR_DBD_TR2_like	145..231	CDD:143525	47/86 (55%)
Nr2c2	XP_038964192.1	NR_LBD_TR2_like	394..615	CDD:132750	68/224 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44866
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910