DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr51 and nr2e3

DIOPT Version :9

Sequence 1:	NP_611032.2	Gene:	Hr51 / 36702	FlyBaseID:	FBgn0034012	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001007369.1	Gene:	nr2e3 / 492496	ZFINID:	ZDB-GENE-041114-63	Length:	419	Species:	Danio rerio

Alignment Length:	501	Identity:	242/501 - (48%)
Similarity:	299/501 - (59%)	Gaps:	99/501 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ANSMNHSSAAEGSSMTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQA 149
            :||.:.|.  :|.|....|..|.||:|.||.||||||||||.|||||||||||||||:|||||||
Zfish    15 SNSTDDSQ--DGKSPAPGKVLNTGLLCKVCSDTSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQA 77

  Fly   150 GTGRCVVDKAHRNQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETL---REMEHGRALREA 211
            |||.|.|||||||||||||||||||.||||||||||||||:||.:|.:.|   ::.||.....|.
Zfish    78 GTGMCPVDKAHRNQCQACRLKKCLQAGMNKDAVQNERQPRSTAQVRLDALDVDKDKEHLATTLEP 142

  Fly   212 AVAVGVFGPPVLLSPPCYGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAG 276
            .           .|..|   .::..|.|||          .::||:.
Zfish   143 T-----------SSSTC---SVISRPLLGS----------SISSSIS------------------ 165

  Fly   277 VHHSPKEKAYGMEMATSGNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMEND 341
                          :|.|: .||.:..:.|....|....|...:                 :|.:
Zfish   166 --------------STDGS-QHSNSPKNGHRFMASLMTAETCAK-----------------LEPE 198

  Fly   342 NDDDSIDVTNDNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFA 406
            :.|::||||::  ||...|....|.:.|        :.:.|:|||||||||||:||||||||.|:
Zfish   199 DVDENIDVTSN--EPERSSPMYGSALYP--------SREPESVYETSARLLFMSVKWAKNLPVFS 253

  Fly   407 RLSFRDQVILLEESWSELFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAAD 471
            .|.||||||||||:|||||||.||||.:|||  .|.|.|:.:    |.....|    .....|:|
Zfish   254 HLPFRDQVILLEEAWSELFLLCAIQWSLPLD--NCPLLSLPD----LSPTGQG----KGSPSASD 308

  Fly   472 VRTLHEIFCKYKAVLVDPAEFACLKAIVLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQ 536
            ||.|.|:|.::|.:.|||.|||||||||||:|||||||||.|:||||||:.|:|:||..|.:.:|
Zfish   309 VRVLQEVFSRFKPLQVDPTEFACLKAIVLFKPETRGLKDPEQVENLQDQSQVLLAQHIHTLYPSQ 373

  Fly   537 IARFGRLLLMLPLLRMISSHKIESIYFQRTIGNTPMEKVLCDMYKN 582
            :||||||||:||.|..:||.:||.::||||||||||||:||||:||
Zfish   374 VARFGRLLLLLPSLHFVSSERIEHLFFQRTIGNTPMEKLLCDMFKN 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	78/90 (87%)
Hr51	NP_611032.2	NR_LBD_Tlx_PNR_like	354..569	CDD:132748	120/214 (56%)
nr2e3	NP_001007369.1	NR_DBD_PNR	31..122	CDD:143528	78/90 (87%)
nr2e3	NP_001007369.1	NR_LBD_Tlx_PNR_like	201..406	CDD:132748	125/224 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594740
Domainoid	1	1.000	217	1.000	Domainoid score	I2628
eggNOG	1	0.900	-	-		E33208_3BF3C
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84397
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1650
OMA	1	1.010	-	-		QHG48225
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	1	1.000	-	-		oto38689
orthoMCL	1	0.900	-	-		OOG6_108159
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3420
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800