DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr51 and tll

DIOPT Version :9

Sequence 1:	NP_611032.2	Gene:	Hr51 / 36702	FlyBaseID:	FBgn0034012	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	157/531 - (29%)
Similarity:	232/531 - (43%)	Gaps:	135/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 NSMNHSSAAEGSSMTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQA- 149
            ||:..|.||....:..:.       |.||.|.||||||||.||:||:||||||:||...|.|::
  Fly    16 NSVRLSPAASSRILYHVP-------CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQ 73

  Fly   150 GTGRCVVDKAHRNQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVA 214
            ..|.|||||.|||||:||||:||.::||||||||:||.|||:      |||  .|....::|.:
  Fly    74 KQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNS------TLR--RHMAMYKDAMM- 129

  Fly   215 VGVFGPPVLLSPPCYGSGLLPPPSLGSLPTGRLLHHNHLTS----SMQLAANHMGAGSFPMFNAA 275
                           |:|.:|     .:|...|::...||.    .|.:......||..|...||
  Fly   130 ---------------GAGEMP-----QIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAA 174

  Fly   276 GVHHSPKEKAYGMEMATSGNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMEN 340
              ...|...|..::::.. .|.|......:|.....:.|..||          .:..:..||
  Fly   175 --FQPPPSAAAVLDLSVP-RVPHHPVHQGHHGFFSPTAAYMNA----------LATRALPPT--- 223

  Fly   341 DNDDDSIDVTNDNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSF 405
                                             |.|...:|  :.||:|..||..|.|.|::.:|
  Fly   224 ---------------------------------PPLMAAEH--IKETAAEHLFKNVNWIKSVRAF 253

  Fly   406 ARLSFRDQVILLEESWSELFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDT--CITKEEL 468
            ..|...||::||||||.|.|:|...|:.:|::  ...|..|.|     ..|||.:.  .:|:|
  Fly   254 TELPMPDQLLLLEESWKEFFILAMAQYLMPMN--FAQLLFVYE-----SENANREIMGMVTRE-- 309

  Fly   469 AADVRTLHEIFCKYKAVLVDPAEFACLKAIVLFR-----------------------------PE 504
               |....|:..:...:.:|..|:.||:||.|||                             .|
  Fly   310 ---VHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAE 371

  Fly   505 TRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSHKIESIYFQRTIGN 569
            :|||.:..::..:.:.|...|..:.:....:|..||..||.::.|:..:||..||.::|::|||:
  Fly   372 SRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGD 436

  Fly   570 TPMEKVLCDMY 580
            ..:.:::.|||
  Fly   437 ITIVRLISDMY 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	56/91 (62%)
Hr51	NP_611032.2	NR_LBD_Tlx_PNR_like	354..569	CDD:132748	64/245 (26%)
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	56/104 (54%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	66/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444766
Domainoid	1	1.000	55	1.000	Domainoid score	I7416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
	7	6.950