DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr51 and Nr2c1

DIOPT Version :9

Sequence 1:	NP_611032.2	Gene:	Hr51 / 36702	FlyBaseID:	FBgn0034012	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_665723.1	Gene:	Nr2c1 / 252924	RGDID:	3200	Length:	590	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	153/526 - (29%)
Similarity:	246/526 - (46%)	Gaps:	104/526 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRLKKCLQ 174
            :||||||.:||:|||.:.|.||.||||||:|:.|:|.|: |:..|:::|.|||:||.|||::|:.
  Rat   100 LCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCR-GSKDCIINKHHRNRCQYCRLQRCIA 163

  Fly   175 MGMNKDAVQNERQP------------------------RNTATIRPETLREMEHGRA--LREAAV 213
            .||.:|:||.||:|                        |:.....|..:.:.|..|:  |.::.:
  Rat   164 FGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSTGLLDSGM 228

  Fly   214 AV-----GVFGPPVLLSPP-----CYGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLA----ANHM 264
            .|     |:...|.||..|     |.|       .||:|.       :.:||...|.    .:|.
  Rat   229 FVNIHPSGIKTEPALLMTPDKAESCQG-------DLGTLA-------SVVTSLANLGKAKDLSHC 279

  Fly   265 GAGSFPMFNAA-------GVHHSPKEKAYGMEMATSGNVSHSTNSSSNHSIDPSSPA---PENAK 319
            | |..|:..:.       |..|        .::.|:|:||.:.::.:.......:||   |..:.
  Rat   280 G-GDLPVVQSLRNGDTSFGAFH--------QDIQTNGDVSRAFDNLAKALTPGENPACQSPGESM 335

  Fly   320 EINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETV 384
            |     ||...::.....||.:.     .:.:|:   |.|.|......||::::.:.       :
  Rat   336 E-----GSTHLIAGEPSCMEREG-----PLLSDS---HVVFRLTMPSPMPEYLNVHY-------I 380

  Fly   385 YETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSELFLLNAIQ-WCIPLDPTGCALFSVAE 448
            .|:::||||:::.||.::|||..|...:.:.|::..|:|||.|...| |.:....|..|.|
  Rat   381 GESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATF---- 441

  Fly   449 HCNNLENNANGDTCITKEE--LAADVRTLHEIFCKYKAVL-VDPAEFACLKAIVLFRPETRGLKD 510
             .|.|.|:...|....:..  |...:..|.| ||.....| :|..|:|.|||||||.|:..||::
  Rat   442 -VNCLHNSLQQDKMSPERRKLLMEHIFKLQE-FCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLEN 504

  Fly   511 PAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSHKIESIYFQRTIGNTPMEKV 575
            ...||..|::|:|....:....:.....|..||||.||.||::::...|.::|:..|||..::.|
  Rat   505 MELIEKFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSV 569

  Fly   576 LCDMYK 581
            :..:.|
  Rat   570 IPHILK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	45/107 (42%)
Hr51	NP_611032.2	NR_LBD_Tlx_PNR_like	354..569	CDD:132748	67/218 (31%)
Nr2c1	NP_665723.1	Required for interaction with KAT2B. /evidence=ECO:0000250	1..166		36/66 (55%)
		NR_DBD_TR2_like	96..182	CDD:143525	44/82 (54%)
		NR_LBD_TR2_like	355..576	CDD:132750	72/237 (30%)
		Required for interaction with NRIP1. /evidence=ECO:0000250	571..590		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44866
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910