Protein Alignment Hr51 and Nr2e1

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_689415.1
• Gene: Nr2e1 / 21907
• MGIID: 1100526
• Length: 385
• Species: Mus musculus
• Alignment Length: 500
• Identity: 174/500 - (34%)
• Similarity: 255/500 - (51%)
• Gaps: 139/500 - (27%)

  Fly    98 SMTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGT-GRCVVDKAHR 161
            |.:||    |.:.|.||||.|||||||:.||:|||||||||:||...|.|::|. |.|.|||.||
Mouse     7 STSRI----LDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHR 67

  Fly   162 NQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETL-----REMEHGRALREAAVAVGVFGPP 221
            |||:||||||||::.|||||||:||.|| |:|||.:..     .:.::|.|..
Mouse    68 NQCRACRLKKCLEVNMNKDAVQHERGPR-TSTIRKQVALYFRGHKEDNGAAAH------------ 119

  Fly   222 VLLSPPCYGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAY 286
                   :.|..||.|:.             .|:..||                        :.:
Mouse   120 -------FPSTALPAPAF-------------FTAVTQL------------------------EPH 140

  Fly   287 GMEMATSGNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTN 351
            |:|:|.                  .|..||..          :.||.:.||
Mouse   141 GLELAA------------------VSATPERQ----------TLVSLAQPT-------------- 163

  Fly   352 DNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVIL 416
             .:.||.|:.:      |.:    ||....|:|.|::||||||::||||::|:|:.||.:||::|
Mouse   164 -PKYPHEVNGT------PMY----LYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLML 217

  Fly   417 LEESWSELFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKE--ELAADVRTLHEIF 479
            ||::|.|||:|...||.||:|..  .|.:|        :..|.|...:::  ::.::::.|.|:.
Mouse   218 LEDAWRELFVLGIAQWAIPVDAN--TLLAV--------SGMNTDNTDSQKLNKIISEIQALQEVV 272

  Fly   480 CKYKAVLVDPAEFACLKAIVLFR-------PETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQI 537
            .:::.:.:|..||||||.||.|:       .|.|..::.|.|..|||:|.:.|:.:..|::..|.
Mouse   273 ARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQP 337

  Fly   538 ARFGRLLLMLPLLRMISSHKIESIYFQRTIGNTPMEKVLCDMYKN 582
            .|||:|||:||.||.||...||.::|::||||.|:.::|.||||:
Mouse   338 CRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKS 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	59/91 (65%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	82/223 (37%)
Nr2e1	NP_689415.1	NR_DBD_TLX	8..99	CDD:143537	61/95 (64%)
		NR_LBD_Tlx_PNR_like	154..369	CDD:132748	86/259 (33%)
		Required for transcriptional repression	341..385		23/41 (56%)