Protein Alignment Hr51 and Rxra

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_035435.1
• Gene: Rxra / 20181
• MGIID: 98214
• Length: 467
• Species: Mus musculus
• Alignment Length: 599
• Identity: 154/599 - (25%)
• Similarity: 225/599 - (37%)
• Gaps: 219/599 - (36%)

  Fly    13 SSQELHSPQRHCYTP-----PP-----APM--HGQAPPPTST---GVAPPTQPPPPHPAA----- 57
            |..:||||.....:|     ||     :||  |..:.|.|.|   |...|....|.:|.:
Mouse    48 SPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDI 112

  Fly    58 ------------PNVPNGRLLSWNHSAAAAAAAAAAQAAANSMNHSSAAEGSSMTRIKGQNLGLI 110
                        |..|:|.:.|:.                   .|                   |
Mouse   113 KPPLGLNGVLKVPAHPSGNMASFT-------------------KH-------------------I 139

  Fly   111 CVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRLKKCLQM 175
            |.:|||.|||||||:.:|.||.|||||:||:.|.|.|:.... |::||..||:||.||.:|||.|
Mouse   140 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD-CLIDKRQRNRCQYCRYQKCLAM 203

  Fly   176 GMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLSPPCYGSGLLPPPSLG 240
            ||.::|||.|||
Mouse   204 GMKREAVQEERQ----------------------------------------------------- 215

  Fly   241 SLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATSGNVSHSTNSSSN 305
               .|:..:.|.:.|:.  :||               ...|.||....|:|.....  .|...:|
Mouse   216 ---RGKDRNENEVESTS--SAN---------------EDMPVEKILEAELAVEPKT--ETYVEAN 258

  Fly   306 HSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHAVSRSDSSFIMPQ 370
            ..::||||                            ||    .|||
Mouse   259 MGLNPSSP----------------------------ND----PVTN------------------- 272

  Fly   371 FMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSELFLLNAIQWCIP 435
                         :.:.:.:.||..|:|||.:|.|:.|...||||||...|:||.:.:.....|.
Mouse   273 -------------ICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIA 324

  Fly   436 LDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVDPAEFACLKAIVL 500
            :.........:..|.|:..:...|         |...|.|.|:..|.:.:.:|..|..||:||||
Mouse   325 VKDGILLATGLHVHRNSAHSAGVG---------AIFDRVLTELVSKMRDMQMDKTELGCLRAIVL 380

  Fly   501 FRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSHKIESIYFQR 565
            |.|:::||.:||::|.|:::.:..|..:.|.::..|..||.:|||.||.||.|....:|.::|.:
Mouse   381 FNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFK 445

  Fly   566 TIGNTPMEKVLCDM 579
            .||:||::..|.:|
Mouse   446 LIGDTPIDTFLMEM 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	46/90 (51%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	59/214 (28%)
Rxra	NP_035435.1	Modulating domain. /evidence=ECO:0000250	1..139		23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..112		18/63 (29%)
		Nuc_recep-AF1	18..132	CDD:463363	21/83 (25%)
		NR_DBD_RXR	138..214	CDD:143514	44/95 (46%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P19793	165..170		3/4 (75%)
		Hinge	206..229		9/78 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..233		9/94 (10%)
		NR_LBD_RXR_like	234..445	CDD:132741	74/285 (26%)
		Required for nuclear export. /evidence=ECO:0000250|UniProtKB:P19793	353..373		6/19 (32%)