Protein Alignment Hr51 and nhr-49

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001367039.1
• Gene: nhr-49 / 172839
• WormBaseID: WBGene00003639
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 478
• Identity: 120/478 - (25%)
• Similarity: 187/478 - (39%)
• Gaps: 105/478 - (21%)

  Fly   111 CVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRLKKCLQM 175
            |.||||.|:|.|||:::||||.|||:|:|.|...:.|:... |||:||..|..|:.||.:||:|:
 Worm    35 CAVCGDKSTGTHYGVISCNGCKGFFRRTVLRDQKFTCRFNK-RCVIDKNFRCACRYCRFQKCVQV 98

  Fly   176 GMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLS-PPCYGSGLLPPPSL 239
            ||.::|:|.||.|..:.|          .|.:|.         |.|.... .|.|.:|
 Worm    99 GMKREAIQFERDPVGSPT----------SGASLN---------GTPFKKDRSPGYENG------- 137

  Fly   240 GSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATSGNVSHSTNSSS 304
                                .:|.:|:......|...|..|.......|||....| ....|...
 Worm   138 --------------------NSNGVGSNGMGQENMRTVPQSSSVIDALMEMEARVN-QEMCNRYR 181

  Fly   305 NHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHAVSRSDSSFIMP 369
            ...|..:.....|..:.:|..||.|..|:.:|
 Worm   182 RSQIFANGSGGSNGNDTDIQQGSDSGASAFAP--------------------------------- 213

  Fly   370 QFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEE-SWSELFLLNAIQWC 433
                ||........:.|.|...|.:.|:|||.:..|..||..|::|||:. :...|.|:.|.:
 Worm   214 ----PNRPCTTEVDLNEISRTTLLLMVEWAKTINPFMDLSMEDKIILLKNYAPQHLILMPAFR-- 272

  Fly   434 IPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVDPAEFACLKAI 498
             ..|.|...||:......:...:.||........:..  |.|.||....:.:.:...||.||||:
 Worm   273 -SPDTTRVCLFNNTYMTRDNNTDLNGFAAFKTSNITP--RVLDEIVWPMRQLQMREQEFVCLKAL 334

  Fly   499 VLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQI--------ARFGRLLLMLPLLRMISS 555
            ....||.:||.:.:|| .::|..:.:|    |..:...:        .|:|.:||:.|.|:.::.
 Worm   335 AFLHPEAKGLSNSSQI-MIRDARNRVL----KALYAFILDQMPDDAPTRYGNILLLAPALKALTQ 394

  Fly   556 HKIESIYFQRTIGNTPMEKVLCD 578
            ..||::...:..|...::.:|.:
 Worm   395 LLIENMTLTKFFGLAEVDSLLSE 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	40/82 (49%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	52/223 (23%)
nhr-49	NP_001367039.1	NR_DBD_HNF4A	35..110	CDD:143518	38/75 (51%)
		HOLI	228..382	CDD:214658	43/163 (26%)