Protein Alignment Hr51 and Nr2f6

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_034280.2
• Gene: Nr2f6 / 13864
• MGIID: 1352453
• Length: 390
• Species: Mus musculus
• Alignment Length: 514
• Identity: 162/514 - (31%)
• Similarity: 211/514 - (41%)
• Gaps: 164/514 - (31%)

  Fly    72 AAAAAAAAAAQAAANSMNHSSAAEGSSMTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFK 136
            |..:...|....:|:....:|.||.....|   ..|.:.||||||.|||||||:..|.||..|||
Mouse    21 AGGSYPRATEDDSASPPGATSDAEPGDEER---PGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFK 82

  Fly   137 RSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLRE 201
            ||:||.|.|.|::... |.:|:.||||||.||||||.::||.|:|||..|.|....
Mouse    83 RSIRRNLSYTCRSNRD-CQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALP--------- 137

  Fly   202 MEHGRALREAAVAVGV---FGPPVLLSPPCYGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANH 263
               |.|......|.||   .||||                                  .:|.|..
Mouse   138 ---GPAACSPPGATGVEPFTGPPV----------------------------------SELIAQL 165

  Fly   264 MGAGSFPMFNAAGVHHSPKEKAYGMEMATSGNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSV 328
            :.|..:|   |||        .:|                                    .||:|
Mouse   166 LRAEPYP---AAG--------RFG------------------------------------GGGAV 183

  Fly   329 SSVSSSSPTMENDNDDDSIDVTNDNEEPHAVSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLF 393
            ..:                    ||                              |.|.:|||||
Mouse   184 LGI--------------------DN------------------------------VCELAARLLF 198

  Fly   394 MAVKWAKNLPSFARLSFRDQVILLEESWSELFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNAN 458
            ..|:||::.|.|..|...|||.||..||||||:|||.|..:||. |...|.:...|.
Mouse   199 STVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAALPLH-TAPLLAAAGLHA-------- 254

  Fly   459 GDTCITKEELAA---DVRTLHEIFCKYKAVLVDPAEFACLKAIVLFRPETRGLKDPAQIENLQDQ 520
              ..:..|...|   .||...|...|...:.||.||:.|||||.||.|:..||.|||.:|:||::
Mouse   255 --APMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEK 317

  Fly   521 AHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMISSHKIESIYFQRTIGNTPMEKVLCDM 579
            |.|.|:::.:.|:.:|..|||||||.||.||.:.:..|..::|.|.:|.||:|.::.||
Mouse   318 AQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDM 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	49/90 (54%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	78/217 (36%)
Nr2f6	NP_034280.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		6/28 (21%)
		NR_DBD_COUP_TF	57..129	CDD:143516	45/72 (63%)
		NR_LBD_COUP-TF	157..387	CDD:132746	99/362 (27%)
		Important for dimerization. /evidence=ECO:0000250	314..390		27/63 (43%)