Protein Alignment Hr51 and Nr2f2

DIOPT Version :10

• Sequence 1: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_033827.2
• Gene: Nr2f2 / 11819
• MGIID: 1352452
• Length: 414
• Species: Mus musculus
• Alignment Length: 546
• Identity: 170/546 - (31%)
• Similarity: 226/546 - (41%)
• Gaps: 167/546 - (30%)

  Fly    39 PTSTG----VAPPTQPPPPHPAAPNVPNGRLLSWNHSAAAAAAAAAAQAAANSMNHSSAAEGSSM 99
            |.|.|    .|||...||  |.||:.|       ........|:..||.||.... .....||..
Mouse    16 PGSQGSQASQAPPVPGPP--PGAPHTP-------QTPGQGGPASTPAQTAAGGQG-GPGGPGSDK 70

  Fly   100 TRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQC 164
            .:   |...:.||||||.|||||||...|.||..||||||||.|.|.|:|.. .|.:|:.|||||
Mouse    71 QQ---QQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANR-NCPIDQHHRNQC 131

  Fly   165 QACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLSPPCY 229
            |.|||||||::||.::|||..|.|....|          ||:.
Mouse   132 QYCRLKKCLKVGMRREAVQRGRMPPTQPT----------HGQF---------------------- 164

  Fly   230 GSGLLPPPSLGSLPTGRLLH-HNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATS 293
                       :|..|..|: |::|:..:.|..
Mouse   165 -----------ALTNGDPLNCHSYLSGYISLLL-------------------------------- 186

  Fly   294 GNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHA 358
                                                                       ..||:.
Mouse   187 -----------------------------------------------------------RAEPYP 192

  Fly   359 VSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSE 423
            .||..|     |.|.|| .....|.:.|.:||:||.||:||:|:|.|..|...|||.||..:|||
Mouse   193 TSRFGS-----QCMQPN-NIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251

  Fly   424 LFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVD 488
            ||:|||.|..:||. ....|.:...|.:.:    :.|..:.   ....:|...|...|.||:.||
Mouse   252 LFVLNAAQCSMPLH-VAPLLAAAGLHASPM----SADRVVA---FMDHIRIFQEQVEKLKALHVD 308

  Fly   489 PAEFACLKAIVLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMI 553
            .||::||||||||..:..||.|.|.:|:||:::...|.::.::|:..|..|||:|||.||.||.:
Mouse   309 SAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373

  Fly   554 SSHKIESIYFQRTIGNTPMEKVLCDM 579
            ||..||.::|.|.:|.||:|.::.||
Mouse   374 SSSVIEQLFFVRLVGKTPIETLIRDM 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	51/90 (57%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	85/214 (40%)
Nr2f2	NP_033827.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		19/65 (29%)
		NR_DBD_COUP_TF	79..151	CDD:143516	47/72 (65%)
		Interaction with ZFPM2. /evidence=ECO:0000269|PubMed:11382775	117..414		123/432 (28%)
		NR_LBD_COUP-TF	177..411	CDD:132746	93/328 (28%)
		Important for dimerization	337..414		27/63 (43%)