Protein Alignment CG8155 and TBC1D17

DIOPT Version :10

• Sequence 1: NP_611029.3
• Gene: CG8155 / 36698
• FlyBaseID: FBgn0034009
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_078958.2
• Gene: TBC1D17 / 79735
• HGNCID: 25699
• Length: 648
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 147/555 - (26%)
• Similarity: 225/555 - (40%)
• Gaps: 143/555 - (25%)

  Fly   141 LMSPLQSLGVSQKYVQHMQ--TKLGSSILNQM-----EKTFSIVQKAFNL--------SEEHMAN 190
            |:.|..|..:|..: .|:|  .:..|:::::.     ..|||...:..|.        .|...::
Human   185 LVFPHDSSALSNSF-HHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASD 248

  Fly   191 LPP--------------------------RPPMCDSEFRLFLDALGQIQRKDELHRVIFLGGIDP 229
            |||                          .||:.:.|:...:...|::|:..||...||.||:.|
Human   249 LPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSP 313

  Fly   230 SLRRVVWKHLLNVYPGGANGLALDG--HQRMEFMRRKSEQYCRLRDTWKAA----VKRGSVAGEL 288
            ||||..||.||..       |:.:|  .:....:|:|:::|.|::..||:.    .:|.|:   |
Human   314 SLRREAWKFLLGY-------LSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSL---L 368

  Fly   289 AYVTSMVKKDVLRTDRLHPFYAGSDDNQNIAALFNILTTYALNHPSVSYCQGMSDIASPLLVTMN 353
            ....|::::||.||||.:.||.| .:|..:..|.:||.||.:.|..:.|.|||||:.||:|..:.
Human   369 HGYRSLIERDVSRTDRTNKFYEG-PENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQ 432

  Fly   354 DEAQAYICFCAIMSRMRGNFMLDGIAMTQKFAHLTEALSFYDPEFWEYLKSQQADDLLFCYRWLL 418
            :|..|:.|||..|..::|||......|.::...|...|...||...::|.||.:..|.||:||||
Human   433 NEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLL 497

  Fly   419 LELKREFPFEDALRMLEVQWSSLRYRCDGEKELALFEKEFVPITDASVPNSASTFSSSYSATPTS 483
            :..||||||.|.||:.||.|:.|                                       |..
Human   498 IWFKREFPFPDVLRLWEVLWTGL---------------------------------------PGP 523

  Fly   484 PSYLLTKPRESPYTKVCA-LRRQSSSASLSSLSSSVGTSHGLDNTKRLNHSLDDNMSRHATAAAR 547
            ..:||.         .|| |..:..:..||...|:....|..:.|.:|  |::|.::|  ..|..
Human   524 NLHLLV---------ACAILDMERDTLMLSGFGSNEILKHINELTMKL--SVEDVLTR--AEALH 575

  Fly   548 RQRRTSAKVHQSLDESKMLALIEGALDNRNVKLEQNLSAGEETEDDDVFDRKESPSFLETNPFKD 612
            ||.....::..::.|  :|.|...|                         ...||| ...:|...
Human   576 RQLTACPELPHNVQE--ILGLAPPA-------------------------EPHSPS-PTASPLPL 612

  Fly   613 DAQRAPERETTPPVSPGRAFLCSSSSSNLDEDPSD 647
            ...|||   .|||.|...|....||...|.|:..:
Human   613 SPTRAP---PTPPPSTDTAPQPDSSLEILPEEEDE 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8155	NP_611029.3	TBC	225..439	CDD:214540	83/219 (38%)
TBC1D17	NP_078958.2	PH_RBD	7..205	CDD:432305	6/20 (30%)
		Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040	218..309		17/90 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..259		4/18 (22%)
		TBC	307..542	CDD:214540	92/293 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..648		18/80 (23%)