DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Xpc and XPC

DIOPT Version :10

Sequence 1:NP_725451.1 Gene:Xpc / 36697 FlyBaseID:FBgn0004698 Length:1294 Species:Drosophila melanogaster
Sequence 2:NP_004619.3 Gene:XPC / 7508 HGNCID:12816 Length:940 Species:Homo sapiens


Alignment Length:1158 Identity:325/1158 - (28%)
Similarity:470/1158 - (40%) Gaps:327/1158 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 AGGQ-------KEKSPAPQFDCNAGITNLSDSGSEDNNESSFEDKAGNAFDFRGLLENANSLERT 220
            |||:       .:||.|.           |.:..|:..|.:|||:....   :.||...:..:|.
Human     7 AGGEPRGRELRSQKSKAK-----------SKARREEEEEDAFEDEKPPK---KSLLSKVSQGKRK 57

  Fly   221 RDALSKRNVTATPPRSQAATMDVNALLALGENQNYQSVEVEE-REGNQRKKAGRGAPAAPPTLDE 284
            |...........|.:.:.|.:.|       :::|.:.::.|. .:|:..:             |.
Human    58 RGCSHPGGSADGPAKKKVAKVTV-------KSENLKVIKDEALSDGDDLR-------------DF 102

  Fly   285 PSRLSKTKSTRIKRHTKTRPVSTVVANAGDTD-DSDFEEVADADLSSDQDDGETPNISGDL---- 344
            ||.|.|.      .|.|........:|..:.: ::|:|||.:.......|..|:...|..|    
Human   103 PSDLKKA------HHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVK 161

  Fly   345 --EIRVGLEGLRPTKE--QKTQHELEMALKRRLNRDIKDRQILLHKVSLMCQIARSLKYNRLLSE 405
              ||.:.......|:|  :|.:.|.|..|:|.:.|..|......|||.|:|.:|.....|.:.|:
Human   162 PVEIEIETPEQAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQ 226

  Fly   406 SDSLMQATLKLLPSRNAYPTERGTELKYLQSFVTWFKTSIKLLSPNLYSAQSPATKEAILEALLE 470
            .| |....|.::|:|......|..:..||.:.|.||      :.....:|:..|:::..|:..||
Human   227 PD-LHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWF------IGTFTVNAELSASEQDNLQTTLE 284

  Fly   471 QVKRK----EARCKQDMIFIFIALARGMGMHCRLIVNLQPMPLRPAASDLIPIKLRPDDKNKSQT 531
               |:    .||..::::.||:.:.|.:.:..||:::|||:||:.|.                  
Human   285 ---RRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSAT------------------ 328

  Fly   532 VESERESEDEKPKKDKKAGKPAEKESSKSTISKEAEKKNNAKKAEAKPLSKSTTKGSETTKSGTV 596
                  ::.:||.|::....|.   .|..|.|:..|.       ..||.:...||..||...||.
Human   329 ------AKGKKPSKERLTADPG---GSSETSSQVLEN-------HTKPKTSKGTKQEETFAKGTC 377

  Fly   597 -PKVKKELSLSSKLVEKSKHQKAYTSSKSDTSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLS 660
             |..            |.|..|.....:|      |||:|       ||                
Human   378 RPSA------------KGKRNKGGRKKRS------KPSSS-------EE---------------- 401

  Fly   661 SKLVLKSKNQSSFSSNKSDTSFEENPSTSSSSKSLKEETAKLSSSKLEDKKVASPAETKTKVQSS 725
                                  :|.|.                     ||:              
Human   402 ----------------------DEGPG---------------------DKQ-------------- 409

  Fly   726 LLKRVTTQNISESGDSKKPKVAPVDTFSPVAGRTRR--ATVKPKTEEKPQVVGSPVIPKLMLSKV 788
                       |....::|.           ||.||  :.|..|.|......||           
Human   410 -----------EKATQRRPH-----------GRERRVASRVSYKEESGSDEAGS----------- 441

  Fly   789 KQLNAKHSDTENASPANKHLQEQRNTRETRSRSKSPKVLISPSFLKKKSDGADSTSDPQKHQMAP 853
                  .||.|.:|                               .:.||.:|..|:|     .|
Human   442 ------GSDFELSS-------------------------------GEASDPSDEDSEP-----GP 464

  Fly   854 ETKARISPNFLSEALPARQLRSRGQKASSLAIPQLDGGDDVPLPKKRPKLEKLKNSQDSDEVFEP 918
            ..:.:         .||.|....|.|::|                        :..:.|.     
Human   465 PKQRK---------APAPQRTKAGSKSAS------------------------RTHRGSH----- 491

  Fly   919 AKPVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKTDASDMWVEVWSDVEEQWICIDLFKGKL 983
                :|.|.||.:..:....:|......:|.....|.....|.|:||:.:.||:|:|:|...|.:
Human   492 ----RKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVV 552

  Fly   984 HCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRRTKR 1048
            ....|..|.||..:.||.....|..::|||.||...|.|..||.||:..|..||:.||......|
Human   553 GQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDR 617

  Fly  1049 DITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVH 1113
            :..||.:.:..|.|:|||.:|..:|:||||.|:|||||::.:||..|..||:.||||||||||||
Human   618 EKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVH 682

  Fly  1114 LLHSREIWLKSARVVKLGEQPYKVVKA---RPKWDRLTRTVIKDQ-PLEIFGYWQTQEYEPPTAE 1174
            .||||:.|||.||||:|||.|||:||.   |.:..||....:::: .|.:||||||:||:||.|.
Human   683 TLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAV 747

  Fly  1175 NGIVPRNAYGNVELFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFI 1239
            :|.||||.:|||.||...|:|...|.|.||.|.|:.:||:|||..|:.|||||.|..||:.||:|
Human   748 DGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYI 812

  Fly  1240 VCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKY 1292
            |||||::|:..|||.:|.|...||:||.|.|..||||.|.||||||||||::|
Human   813 VCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRY 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XpcNP_725451.1 rad4 345..1294 CDD:273170 287/961 (30%)
PTZ00108 <696..924 CDD:240271 30/229 (13%)
XPCNP_004619.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 18/84 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..136 5/24 (21%)
rad4 147..867 CDD:273170 290/978 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..519 66/440 (15%)
Nuclear localization signal. /evidence=ECO:0000255 390..395 1/10 (10%)
Interaction with RAD23B 496..734 98/237 (41%)
Minimal sensor domain involved in damage recognition 607..766 83/158 (53%)
DNA-binding, preference for heteroduplex DNA 607..741 68/133 (51%)
DNA-binding, preference for single stranded DNA, required for formation of stable nucleoprotein complex 767..831 34/63 (54%)
Interaction with ERCC2 and GTF2H1. /evidence=ECO:0000269|PubMed:12509233 816..940 30/50 (60%)
Interaction with CETN2 847..866 15/19 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..940 325/1158 (28%)

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