Protein Alignment Xpc and LOC4577180

DIOPT Version :10

• Sequence 1: NP_725451.1
• Gene: Xpc / 36697
• FlyBaseID: FBgn0004698
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_001238403.3
• Gene: LOC4577180 / 4577180
• VectorBaseID: AGAMI1_014610
• Length: 1070
• Species: Anopheles gambiae
• Alignment Length: 1411
• Identity: 387/1411 - (27%)
• Similarity: 569/1411 - (40%)
• Gaps: 476/1411 - (33%)

  Fly     1 MSDEEEDSVSEG-----FSASEDEWKPSKD--VKGGESSD------------------------- 33
            :.|:|.|..|..     ||||||||.|.|:  .|..|.|.
Mosquito    16 VDDDEGDEASHASSVGDFSASEDEWTPEKEEQTKVAEKSAPKRKSKAQPAKKPIVPARVSRRIAA 80

  Fly    34 ------DDDSDFDELQAEGGA--AGSSGRSSAVAGKRGSDHKAPSGIKGSSVKKR-KPTGQSLR- 88
                  .::.:..||.|...:  |.||....:.:.:   :.|||...|...|::: ||..:...
Mosquito    81 KRGIVLPEEPETAELPANAQSIPAPSSSEDESASEE---EKKAPKRAKRKPVRRKGKPPARQKSP 142

  Fly    89 --------------SKLYNKYRPPPKTFPTSPSQQKENTPRASGSKNAKTPNESGARNQHGPADS 139
                          .:||.||| |....|..||..|  .|.|..:|..| ||.:..   .|..|
Mosquito   143 SADDEPIKLTTFTVEQLYRKYR-PDLAHPERPSTSK--APAAPPTKRTK-PNSAAG---DGTGD- 199

  Fly   140 SSESSVEDYLVNPADLDLHSTFFAGGQKEKSPAP----QFDCNAGITNLSDSGSEDN-------N 193
            .||||.:||||:|::|||:|.||...::||....    .||||||: .|:||..|::       .
Mosquito   200 ESESSGDDYLVDPSELDLNSDFFRPSEQEKEQRHAVNLYFDCNAGV-ELTDSEEEEDASDRVVGG 263

  Fly   194 ESSF-----EDKAGNAFDFRGLLENAN-------SLERTRDALSKRNVTATPPRSQAATMDVNAL 246
            |||.     |.|..:....:.|::..|       .:.|..:|.:.|||   ||:
Mosquito   264 ESSTTAVDNERKLADVELGKKLIQQINQSSEAYVQMVRLAEAATARNV---PPQ----------- 314

  Fly   247 LALGENQNYQSVEVEEREGNQRKKAGRG--APAAPPTLDEPSRLSKTKSTRIKRHTKTRPVSTVV 309
               |.|.          .|....|||:|  |.|.....::..||.........|..|     .:.
Mosquito   315 ---GGND----------PGAGSSKAGKGKEATAESRQQEDIDRLLVAGEKLPGREGK-----GLT 361

  Fly   310 ANAGDTDDSDFEEVADADLSSDQDDGETPNISGDLEI--RVGLEGLRPTKEQKTQHELEMALKRR 372
            |..|.|   ||.:||.:..::..|   ||.   ::||  ::|.||......||...::..||||.
Mosquito   362 AGFGRT---DFVKVAPSKPAAKAD---TPK---EIEITLKLGPEGDGKGGSQKRTFDVLTALKRF 417

  Fly   373 LNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQATLKLLP----SRNAYPTERG-TELK 432
            :||:.:..||.:|||:|:|.|......|.:|.:...:..|..||||    ..:|.....| |.::
Mosquito   418 MNREKRTSQINVHKVALLCWIGHGTYVNSVLRKPSLMRFALKKLLPGVMGQTSAANRPNGLTNVR 482

  Fly   433 YLQSFVTWFKTSIKLLSPNLY--SAQSPATKEAILEALLEQVKRKEARCKQDMIFIFIALARGMG 495
            |.|....:::.::.|....::  ..|.||..:.::.|    :.:|...|::|.|.:|:.:.|.:|
Mosquito   483 YFQELTRYYRRTVTLKDDTMFYRQRQHPALGKFLIFA----IAKKATYCRRDYILLFVLMLRIVG 543

  Fly   496 MHCRLIVNLQPMPLRPAASDLIPIKLRPDDKNKSQTVESERESEDEKPKKDKKAGKPAEKESSKS 560
            :|.|||: ..|:|.:...||
Mosquito   544 VHARLII-APPVPPKHVPSD--------------------------------------------- 562

  Fly   561 TISKEAEKKNNAKKAEAKPLSKSTTKGSETTKSGTVPKVKKELSLSSKLVEKSKHQKAYTSSKSD 625
                :..|.|                          ||..:|:::..||:|..:.
Mosquito   563 ----QLYKMN--------------------------PKTPQEMAMERKLLEDFRQ---------- 587

  Fly   626 TSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLKSKNQSSFSSNKSDTSFEENPSTSS 690
                                                                             
Mosquito   588 ----------------------------------------------------------------- 587

  Fly   691 SSKSLKEETAKLSSSKLEDKKVASPAETKTKVQSSLLKRVTTQNISESGDSKKPKVAPVDTFSPV 755
                                                                    ||.|:...|
Mosquito   588 --------------------------------------------------------APRDSMVYV 596

  Fly   756 AGRTRRATVKPKTEEKPQVVGSPVIPKLMLSKVKQLNAKHSDTENASPANKHLQEQRNTRETRSR 820
            |.:                            |::.|.||..|:....
Mosquito   597 AKQ----------------------------KLRALIAKQKDSTGKG------------------ 615

  Fly   821 SKSPKVLISPSFLKKKSDGADSTSDPQKHQMAPETKARISPNFLSEALPARQLRSRGQKASSLAI 885
                        :|:::.|                                     |......:|
Mosquito   616 ------------VKRRAAG-------------------------------------GGGGGGFSI 631

  Fly   886 PQLDGGDDVPLPKKRPKLEKLKNSQDS----DEVFEPAKPV-----KKAPVLPKSVQNLR----- 936
            ||||||.|.|....|.|.:|||..:.|    :...:||.||     ::...:|..||..|
Mosquito   632 PQLDGGADEPSLLARDKKQKLKLMKGSFLRVENNRKPALPVEGDDEEEQSAVPDEVQQRRQRILA 696

  Fly   937 ------------KDRRVMSTDDEGGSRLNRKTDAS-DMWVEVWSDVEEQWICIDLFKGKLHCVDT 988
                        |::......|:|..:.|.|.... |.||||:.:.|::||.||:.||.::.::.
Mosquito   697 AYRARAARLASKKEKDAKRKGDDGKKKANGKVGCGVDYWVEVFCEHEDKWITIDVLKGSVYNLED 761

  Fly   989 IRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRRTKRDITED 1053
            |.|.||..:|||.|:.:|.::|||:.||.:...:...|.|||.|||::.:.||.|:|||||:.||
Mosquito   762 IVKQATQPIAYVLAWNNDGTIKDVSPRYISRLGSKKSKLRVEDAWLEKALRPYRGKRTKRDLIED 826

  Fly  1054 DQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSR 1118
            .:..|:.:.:|.|:.|.|:|:||.|.:||:||:.:.:||.|||.||.||.|.:|.|||||.||||
Mosquito   827 VKFDRLLNKRPFPEQIGEYKNHPKYAIERYLLRNEAIYPRDAPILGHIRDEPIYLRDCVHTLHSR 891

  Fly  1119 EIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAY 1183
            |.||:.|:.|:|.|:|||||||:.|:||.|...|..|.:|:||.||.|:|.||.|::|:|||:||
Mosquito   892 ESWLRQAKTVRLHEEPYKVVKAKAKYDRFTGAAITGQTVELFGEWQVQDYVPPVAKDGLVPRSAY 956

  Fly  1184 GNVELFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFIVCEEFREVV 1248
            |||:||:.|||||.||||:||||.|||:::.||||.|:.||::..|.|..:||||:||||||:.:
Mosquito   957 GNVDLFQPCMLPKGTVHLQLPGLNRICRRMRIDCAQAITGFEYRNGGCQAVYDGFVVCEEFRDRL 1021

  Fly  1249 TAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKYNF 1294
            ...|..:|.....||.|:...|:||||::||.||.||::||.:|||
Mosquito  1022 LDEWYAEQVELQEKEDERRRKRIYGNWRRLIMGLCIRKKLKDRYNF 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpc	NP_725451.1	rad4	345..1294	CDD:273170	273/984 (28%)
		PTZ00108	<696..924	CDD:240271	32/236 (14%)
LOC4577180	XP_001238403.3	None