DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpc and Xpc

DIOPT Version :9

Sequence 1:	NP_725451.1	Gene:	Xpc / 36697	FlyBaseID:	FBgn0004698	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_001101344.1	Gene:	Xpc / 312560	RGDID:	1305760	Length:	933	Species:	Rattus norvegicus

Alignment Length:	1145	Identity:	321/1145 - (28%)
Similarity:	480/1145 - (41%)	Gaps:	307/1145 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 AGGQKEKSPAPQFDCNAGITNLSDSGSEDNNESSFEDKAGNAFDFRGLLENANSLERTRDALSKR 227
            |||::.|......|..|  |...:|.::|     |||:.... ..:..|...:..:|.||.....
  Rat     7 AGGKRRKRGQEAEDNKA--TRPEESDADD-----FEDEKQKP-PRKCFLPKVSQGKRKRDCSDPG 63

  Fly   228 NVTATPPRSQAATMDVNALLALGENQNYQSVEVEEREGNQRKKAGRGAPAAPPTLDEPSRLSKTK 292
            :.|....:.:.|.       |..:::|.::|:.|....:                .:..|.|.:.
  Rat    64 DPTNGAAKKKVAK-------ATTKSKNLKAVKEEALSDD----------------GDDFRDSLSN 105

  Fly   293 STRIKRHTKTRPVSTVVANAGDTDDS--DFEE-------VADADLSSDQDDGETPNISGDLEIRV 348
            ..:.|:|    |...||....|.|||  |:||       |.|...:|.....:.|..:.::||..
  Rat   106 CRKAKKH----PKREVVDQGTDEDDSEDDWEEVEELTEPVLDMGENSATSRSDLPVKAVEIEIET 166

  Fly   349 GLEGLRPTKEQKTQHELEMALKRRLNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQAT 413
            ..:.....:.:|.:.|.|..|:|.:.|..|:.|..:|||.|:|.:|.....|.:..:.| |:...
  Rat   167 PEQAKARERSEKIKMEFETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICQQPD-LLAIG 230

  Fly   414 LKLLPSRNAYPTERGTELKYLQSFVTWFKTSIKLLSPNLYSAQSPATKEAILEALLE-QVKRKEA 477
            |.::|.|......:..::.||.:.|.||      :.....:|...|:::..|:..|| ::....|
  Rat   231 LSIIPIRFTKVPLQDRDVYYLSNLVKWF------IGTFTVNADLSASEQDSLQTTLERRIAIYSA 289

  Fly   478 RCKQDMIFIFIALARGMGMHCRLIVNLQPMPLRPAASDLIPIKLRPDDKNKSQTVESERESEDEK 542
            |..::::.||:.:.|.:.:..||:::|||:||:.|.:
  Rat   290 RDNEELVHIFLLILRALQLLTRLVLSLQPIPLKSAVA---------------------------- 326

  Fly   543 PKKDKKAGKPAEKESSKSTISKEAEKKNNAKKAEAKPLSKSTTKGSETTKSGTVPKVKKELSLSS 607
                  .||.:.||:|.......:|..:|..::..||.:....|..||...|           |.
  Rat   327 ------KGKKSSKETSLEGPGDSSEPSSNIPESHNKPKTSKRIKQEETLSEG-----------SG 374

  Fly   608 KLVEKSKHQKAYTSSKSDTSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLKSKNQSS 672
            |...:.|...|...|:.    ..|||.|...:..:|..|.....|:    .:::|:..|.:::|.
  Rat   375 KANARGKRGTATAGSRQ----QRKPSCSEGEEAKQEIQSHPQAQKR----RVAAKVSYKEESESD 431

  Fly   673 FSSNKSDTSFEENPSTSSSSKSLKEETAKLSSSKLEDKKVASPAETKTKVQSSLLKRVTTQNISE 737
            .:.:.||  ||                  |||.:
  Rat   432 GAGSGSD--FE------------------LSSGE------------------------------- 445

  Fly   738 SGDSKKPKVAPVDTFSPVAGRTRRATVKPKTEEKPQVVGSPVIPKLMLSKVKQLNAKHSDTENAS 802
                                                                   .:||..|:..
  Rat   446 -------------------------------------------------------GQHSSDEDCK 455

  Fly   803 PANKHLQEQRNTRETRSRSKSPKVLISPSFLKKKSDGADSTSDPQK-HQMAPETKARISPNFLSE 866
            |..:  :::|.:...||::                 |:.|.|..|. .|..|       |:| |.
  Rat   456 PGPR--KQKRASAPQRSKA-----------------GSKSASKTQSGSQWEP-------PSF-SV 493

  Fly   867 ALPARQLRSRGQKASSLAIPQLDGGDDVPLPKKRPKLEKLKNSQDSDEVFEPAKPVKKAPVLPKS 931
            |..:.....||:|.|.       ||::
  Rat   494 ASSSSSACKRGKKISC-------GGEE-------------------------------------- 513

  Fly   932 VQNLRKDRRVMSTDDEGGSRLNRKTDASDMWVEVWSDVEEQWICIDLFKGKLHCVDTIRKNATPG 996
                        |||       ||....|.|:||:.:.:.:|:|:|...|.:.......|.||..
  Rat   514 ------------TDD-------RKAAGVDQWLEVFCEPQAKWVCVDCVHGVVGQPVACYKYATKP 559

  Fly   997 LAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRRTKRDITEDDQLRRIHS 1061
            :.||.....|..::|||.||..:|.|..||.||:..|..||:.||....|:|:..||.:.:..|.
  Rat   560 MTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSPLTEREKKEDQEFQAKHL 624

  Fly  1062 DKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSAR 1126
            |:|||.|||.:|:||||.|:|||||||.:||..|..||:.||||||||||||.||||:.|||.||
  Rat   625 DQPLPTSISTYKNHPLYALKRHLLKFQAIYPESAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQAR 689

  Fly  1127 VVKLGEQPYKVVKA---RPKWDRLTRTVIKD-QPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVE 1187
            ||:|||.|||:||.   |.:..||:...:.| ..|.:||:|||:||:||.|.:|.||||.:|||.
  Rat   690 VVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLFGHWQTEEYQPPVAVDGKVPRNEFGNVY 754

  Fly  1188 LFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFIVCEEFREVVTAAW 1252
            ||...|:|...|.:.||.|.|:.:||.|||..|:.|||||.|.|||:.||::||||||:|:.|||
  Rat   755 LFLPSMMPIGCVQMNLPNLHRVARKLGIDCVQAITGFDFHGGYCHPVTDGYVVCEEFRDVLLAAW 819

  Fly  1253 EEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKY 1292
            |.:|.:...||:||.|.|..||||.|::|||||||||.:|
  Rat   820 ENEQALIEKKEKEKKEKRALGNWKLLVRGLLIRERLKLRY 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpc	NP_725451.1	rad4	345..1294	CDD:273170	281/954 (29%)
		Rad4	925..1057	CDD:281786	39/131 (30%)
		BHD_1	1062..1112	CDD:214984	34/49 (69%)
		BHD_2	1115..1170	CDD:214985	31/58 (53%)
		BHD_3	1178..1252	CDD:198100	41/73 (56%)
Xpc	NP_001101344.1	rad4	144..860	CDD:273170	139/726 (19%)
		TEBP_beta	<399..489	CDD:254188	21/89 (24%)
		Rad4	<525..620	CDD:281786	5/94 (5%)
		BHD_1	624..675	CDD:214984	7/50 (14%)
		BHD_2	678..737	CDD:214985	16/59 (27%)
		BHD_3	745..819	CDD:198100	10/73 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353835
Domainoid	1	1.000	95	1.000	Domainoid score	I7258
eggNOG	1	0.900	-	-		E1_COG5535
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1523
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395919at33208
OrthoFinder	1	1.000	-	-		FOG0002146
OrthoInspector	1	1.000	-	-		oto95833
orthoMCL	1	0.900	-	-		OOG6_102113
Panther	1	1.100	-	-	LDO	PTHR12135
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1843
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760