Protein Alignment Xpc and Xpc

DIOPT Version :10

• Sequence 1: NP_725451.1
• Gene: Xpc / 36697
• FlyBaseID: FBgn0004698
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_033557.2
• Gene: Xpc / 22591
• MGIID: 103557
• Length: 930
• Species: Mus musculus
• Alignment Length: 1120
• Identity: 305/1120 - (27%)
• Similarity: 456/1120 - (40%)
• Gaps: 295/1120 - (26%)

  Fly   189 SEDNNESSFEDKAGNAF-DFRGLLENANSLERTRDALSKRNVT-ATPPRSQAATMDVNALLALGE 251
            :|||..:..|:...:.| |.:......:|..:......||..: ...|.:.||...|....|..:
Mouse    18 TEDNKVARHEESVADDFEDEKQKPRRKSSFPKVSQGKRKRGCSDPGDPTNGAAKKKVAKATAKSK 82

  Fly   252 NQNYQSVEVEEREGNQRKKAGRGAPAAPPTLDEPSRLSKTKSTRIKRHTKTRPVSTVVANAGDTD 316
            |     ::|.:.|........|.:||              ...:.|:|    |.|.||....|.|
Mouse    83 N-----LKVLKEEALSDGDDFRDSPA--------------DCKKAKKH----PKSKVVDQGTDED 124

  Fly   317 DS--DFEE-------VADADLSSDQDDGETPNISGDLEIRVGLEGLRPTKEQKTQHELEMALKRR 372
            ||  |:||       |.|...:|.....:.|..:.::||....:.....:.:|.:.|.|..|:|.
Mouse   125 DSEDDWEEVEELTEPVLDMGENSATSPSDMPVKAVEIEIETPQQAKERERSEKIKMEFETYLRRM 189

  Fly   373 LNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQATLKLLPSRNAYPTERGTELKYLQSF 437
            :.|..|:.|..:|||.|:|.:|.....|.:..:.| |:...|.::|.|......:..:..||.:.
Mouse   190 MKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPD-LLAIGLSIIPIRFTKVPLQDRDAYYLSNL 253

  Fly   438 VTWFKTSIKLLSPNLYSAQSPATKEAILEALLE-QVKRKEARCKQDMIFIFIALARGMGMHCRLI 501
            |.||      :.....:|...|:::..|:..|| ::....||..::::.||:.:.|.:.:..||:
Mouse   254 VKWF------IGTFTVNADLSASEQDDLQTTLERRIAIYSARDNEELVHIFLLILRALQLLTRLV 312

  Fly   502 VNLQPMPLRPAASDLIPIKLRPDDKNKSQTVESERESEDEKPKKDKKAGKPAEKESSKSTISKEA 566
            ::|||:||:.|.:                                  .|:.:.||:|.......:
Mouse   313 LSLQPIPLKSAVT----------------------------------KGRKSSKETSVEGPGGSS 343

  Fly   567 EKKNNAKKAEAKPLSKSTTKGSETTKSGTVPKVKKELSLSSKLVEKSKHQKAYTSSKSDTSFDEK 631
            |..:|:.::..||.:....|..||...|           ..|...:.|.......|:.    ..|
Mouse   344 ELSSNSPESHNKPTTSRRIKEEETLSEG-----------RGKATARGKRGTGTAGSRQ----RRK 393

  Fly   632 PSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLKSKNQSSFSSNKSDTSFEENPSTSSSSKSLK 696
            ||.|...:
Mouse   394 PSCSEGEE--------------------------------------------------------- 401

  Fly   697 EETAKLSSSKLEDKKVASPAETKTKVQSSLLKRVTTQNISESGDSKKPKVAPVDTFSPVAGRTRR 761
                               ||.|.:.:....||.....:|...:|:.........|.|.:|
Mouse   402 -------------------AEQKVQGRPHARKRRVAAKVSYKEESESDGAGSGSDFEPSSG---- 443

  Fly   762 ATVKPKTEEKPQVVGSPVIPKLMLSKVKQLNAKHSDTENASPANKHLQEQRNTRETRSRSKSPKV 826
                                          ..:||..|:..|..:          .:.|:.:|
Mouse   444 ------------------------------EGQHSSDEDCEPGPR----------KQKRASAP-- 466

  Fly   827 LISPSFLKKKSDGADSTSDPQKHQMAPETKARISPNFLSEALPARQLRSRGQKASSLAIPQLDGG 891
                   ::...|:.|.|..|:       .::..|:...||..:.....||:|.||       |.
Mouse   467 -------QRTKAGSKSASKTQR-------GSQCEPSSFPEASSSSSGCKRGKKVSS-------GA 510

  Fly   892 DDVPLPKKRPKLEKLKNSQDSDEVFEPAKPVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKT 956
            :::                                                         .:||.
Mouse   511 EEM---------------------------------------------------------ADRKP 518

  Fly   957 DASDMWVEVWSDVEEQWICIDLFKGKLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWS 1021
            ...|.|:||:.:.:.:|:|:|...|.:.......|.||..:.||.....|..::|||.||..:|.
Mouse   519 AGVDQWLEVYCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWM 583

  Fly  1022 TTVRKARVEKAWLDETIAPYLGRRTKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLK 1086
            |..||.||:..|..||:.||....|:|:..||.:.:..|.|:|||.|||.:|:||||.|:|||||
Mouse   584 TATRKCRVDAEWWAETLRPYRSLLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLK 648

  Fly  1087 FQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKA---RPKWDRLT 1148
            ||.:||..|..||:.||||||||||||.||||:.|||.||||:|||.|||:||.   |.:..||:
Mouse   649 FQAIYPETAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQARVVRLGEVPYKMVKGFSNRARKARLS 713

  Fly  1149 RTVIKD-QPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPGLMRICKK 1212
            ...:.| ..|.::|:|||:||:||.|.:|.||||.:|||.||...|:|...|.:.||.|.|:.:|
Mouse   714 EPQLHDHNDLGLYGHWQTEEYQPPIAVDGKVPRNEFGNVYLFLPSMMPVGCVQMTLPNLNRVARK 778

  Fly  1213 LNIDCANAVVGFDFHQGACHPMYDGFIVCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKK 1277
            |.|||..|:.|||||.|.|||:.||:|||||||:|:.||||.:|.:...||:||.|.|..||||.
Mouse   779 LGIDCVQAITGFDFHGGYCHPVTDGYIVCEEFRDVLLAAWENEQAIIEKKEKEKKEKRALGNWKL 843

  Fly  1278 LIKGLLIRERLKKKY 1292
            |::|||||||||.:|
Mouse   844 LVRGLLIRERLKLRY 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpc	NP_725451.1	rad4	345..1294	CDD:273170	268/953 (28%)
		PTZ00108	<696..924	CDD:240271	29/227 (13%)
Xpc	NP_033557.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134		22/117 (19%)
		rad4	143..859	CDD:273170	130/725 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..517		27/193 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	388..393		0/4 (0%)
		Interaction with RAD23B. /evidence=ECO:0000250	489..727		29/237 (12%)
		Minimal sensor domain involved in damage recognition. /evidence=ECO:0000250	600..759		19/158 (12%)
		DNA-binding, preference for heteroduplex DNA. /evidence=ECO:0000250	600..734		19/133 (14%)
		DNA-binding, preference for single stranded DNA, required for formation of stable nucleoprotein complex. /evidence=ECO:0000250	760..824		12/63 (19%)
		Interaction with ERCC2 and GTF2H1. /evidence=ECO:0000250	809..930		53/120 (44%)
		Interaction with CETN2. /evidence=ECO:0000250	840..859		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	867..930		32/62 (52%)