Protein Alignment Xpc and LOC1275019

DIOPT Version :10

• Sequence 1: NP_725451.1
• Gene: Xpc / 36697
• FlyBaseID: FBgn0004698
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_314239.6
• Gene: LOC1275019 / 1275019
• VectorBaseID: AGAMI1_006637
• Length: 1253
• Species: Anopheles gambiae
• Alignment Length: 1420
• Identity: 421/1420 - (29%)
• Similarity: 654/1420 - (46%)
• Gaps: 298/1420 - (20%)

  Fly     1 MSDEEE--DSVSEG--FSASEDEWKPSKDVK----GGESSDDDDSDFDELQAEGGAAGSSGRS-- 55
            |||||:  ....||  ||||||||.|:||.|    .|:|.|:..|..:|.:.|...:.|:..|
Mosquito     1 MSDEEDILSGSEEGDDFSASEDEWLPTKDSKKKAGKGKSKDESSSAEEEDEDEDDGSSSADESDL 65

  Fly    56 ----SAVAGKRGSD--------HKAPSGIKGSSVKKRKPTGQSLRSKLYNKYRP------PPKTF 102
                ::.|.|:|..        .|:||| |.....|||.....||.:||.:|:.      .|...
Mosquito    66 DDFATSPAKKKGKQPTSRKRAAGKSPSG-KQPGGNKRKRLSPGLRDRLYQQYKKDLLKEIAPSKA 129

  Fly   103 PTSPS----------QQK----ENTPRASGSKNAKTPNESGARNQHGPADSSSESSVEDYLVNPA 153
            |.:.|          |:|    |..|::|...|                  .|:||.:|:||:|.
Mosquito   130 PLNSSVTDILQKCQYQRKTKVTEQAPKSSSVAN------------------DSDSSGDDHLVDPE 176

  Fly   154 DLDLHSTFF--------------AGGQKEKSPAPQFDCNAGITNLSDSG---------------- 188
            .|||.:.||              .|.:.|....||||.|||: .||||.
Mosquito   177 KLDLGAKFFDKSAPPNERPSASKQGEEVEDGGPPQFDVNAGM-RLSDSSDGEGGERHIGEEPLLP 240

  Fly   189 ------------SEDNNESSFEDKAGNAFDFRGLLENANSL-------ERTRDALSKRNVTATPP 234
                        |..|.:||......|...|...:|.|...       |...|:.:.|:..|: .
Mosquito   241 ASIPKQAADKLISHINQQSSEFMNFTNLDQFTAKVEEAKKFLMSYQQRETIADSAAGRDADAS-Q 304

  Fly   235 RSQAATMDVNALLALGENQNYQSVEVEEREGNQRKKAGRGAPAAPPTLDEPSRLSKTKSTRIKRH 299
            .|:....:|::|||:||                 |:.|.|.                      :|
Mosquito   305 TSEQQRENVSSLLAMGE-----------------KEPGTGT----------------------KH 330

  Fly   300 TKTRPVSTVVANAGDTDDSDFEEVADADLSSDQDDGET---PNISGDLEIRVGLEGLRPTKEQKT 361
            .:..           :.|||:|||...:.::.:::..|   ...:...::.:.||..:..::::.
Mosquito   331 EEDA-----------SSDSDWEEVQTGEGTAGKEEEATKPSAETAAGWQVTIELETAQSKRKRRE 384

  Fly   362 QHELEMALKRRLNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQATLKLLPSRNAYPTE 426
            :.|:|:.:||.:||..:..|:..||.|::..|....:.|.::: ..::....:.::.:|.|....
Mosquito   385 ELEMELYIKREINRVKRKNQLNYHKSSVLGAICIGRRLNGIIN-GGAIRGLLMSIMQTRCAEAKV 448

  Fly   427 RGTELKYLQSFVTWFKTSIKLLSPNLYSAQSPATKEAILEALLEQVKRKEARCKQDMIFIFIALA 491
            :..| |.::|...|:|....|:|......::.|....   ||...|..::..|:.|.|.:|:|..
Mosquito   449 KWDE-KKMKSLAEWYKQEFALMSNEFLVPRNGAHCSF---ALSLAVYTRKVACRHDYILLFLACL 509

  Fly   492 RGMGMHCRLIVNLQPMPLRPAASDLIPI-------KLRPDDKNKSQTVESERESEDEKP------ 543
            |..|...||:::....|.||..|||.|:       |......|....|.|::|...:.|
Mosquito   510 RLAGAQARLVLSANVPPKRPPLSDLCPMSERQIKEKFEKRVSNGGGAVGSKQERAVKAPEEAVQP 574

  Fly   544 -----KKDKKAGKPAEKESSKSTISKEAEKKNNAKKAEAKP--LSKSTTKGSETTKSGTVPKVKK 601
                 ||:..|..|  |.:..||:.....|:.....|:..|  .|:.:.:||    .||   |:|
Mosquito   575 KSIELKKEDDANPP--KTAPPSTVDAVERKEKLPTPAKENPPAPSRRSPRGS----GGT---VQK 630

  Fly   602 ELSLSSKLVEKSKHQKAYTSSKSDTSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLK 666
            :::.......:.|........:.|...|.....|            |..:::.|:....:.:..:
Mosquito   631 DIAQPRPPTTRRKALMTLNIPQLDGGDDRLVEAS------------LPAARRSLRSKSVTAVQAE 683

  Fly   667 SKNQSSFSSNKSDTSFEENPST-SSSSKSLKEETAK---LSSSKLEDKKVASPAETKTKVQSSLL 727
            |...|.|:..||:|     |:| :::|||....|.|   .::::.|.|.|..|....|..:.:..
Mosquito   684 SPGSSPFAKRKSNT-----PTTATNASKSQTIATRKRKLFTAAQPEVKAVPPPPTPPTTSRRTSA 743

  Fly   728 KRVTTQNISESGDSKKPKVAPVDTFSPVAGRTRRATVKPKTEEKPQVVGSPVIPKLMLSKVKQLN 792
            ::...|    :.::|:|||             :|.||:|   :.|
Mosquito   744 RKAAKQ----AAETKEPKV-------------KRRTVRP---DPP-------------------- 768

  Fly   793 AKHSDTENASPANKHLQEQRNTRETRSRSKSPKVLISPSFLKKKSDGADSTSDPQKHQMAPETKA 857
               || ::|........|:::....:...|.||..:....|:   |.|:.:::..| |:..:.:|
Mosquito   769 ---SD-DDAFEVKTKTSEKKSASSGKIVKKDPKPKVPVIVLE---DIANKSTEDDK-QLLGDGEA 825

  Fly   858 RISPNFLSEALPARQLR--------SRGQKASSLAIPQLDGGDDVPLPKKRPKLEKLKNSQDSDE 914
            ...|....|..|.:|.:        :|.||::.::........|..:|....|....|.:..:.:
Mosquito   826 ASVPTSEEEKTPLKQAKATRKRATVTRKQKSAHVSDDSAADDSDFEMPNSAAKERNKKRTSSATK 890

  Fly   915 VFEPAKPVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKTDASDMWVEVWSDVEEQWICIDLF 979
            ..:||:|   :|             |......|.||:  :||   |:|:|.:::..::|:..||.
Mosquito   891 AKKPARP---SP-------------RQKQAGSEQGSK--QKT---DLWIEFYNEKSKRWLPFDLA 934

  Fly   980 KGKLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGR 1044
            ..::.|||.|.:||:..:||||.:.::..||||||||..:|:|..|..|||:|||:..:.|::|.
Mosquito   935 SEQIDCVDLIMRNASNPIAYVFGWDNEGHLKDVTARYVKNWNTACRMLRVEQAWLENVLRPFVGE 999

  Fly  1045 RTKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSR 1109
            :::.|..|:.:|.::.:||||||:|||.|:||||.|.||||||:.|||.:.||||||||||:|.|
Mosquito  1000 KSEMDRLEEKELNKLDADKPLPKTISELKNHPLYALRRHLLKFEALYPAEPPTLGFIRGEAIYPR 1064

  Fly  1110 DCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAE 1174
            :||:.|.:||.|.|..|||:..|..|||||.. |:||.....:||||.:|||.|||.|::|||||
Mosquito  1065 ECVYTLQTREKWYKQGRVVRPFETAYKVVKCW-KYDRPNNNWLKDQPCDIFGLWQTDEFDPPTAE 1128

  Fly  1175 NGIVPRNAYGNVELFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFI 1239
            ||:||||.|||||||.:.||||.||||:||||.::||:|.||||.|:.|||..:....|:||||:
Mosquito  1129 NGVVPRNEYGNVELFTEKMLPKGTVHLKLPGLNKVCKRLQIDCAPALTGFDMAKMRVVPVYDGFV 1193

  Fly  1240 VCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKYNF 1294
            ||:||.|.....|.::.:.:..:||||.|.|||||||:||||||:|.:|:.||||
Mosquito  1194 VCKEFAEQAVEEWYKEMEKEDQREQEKLEKRVYGNWKRLIKGLLVRRKLQNKYNF 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpc	NP_725451.1	rad4	345..1294	CDD:273170	312/980 (32%)
		PTZ00108	<696..924	CDD:240271	44/238 (18%)
LOC1275019	XP_314239.6	None