DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-51L2 and NDUFV1

DIOPT Version :9

Sequence 1:	NP_725449.1	Gene:	ND-51L2 / 36695	FlyBaseID:	FBgn0034007	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_009034.2	Gene:	NDUFV1 / 4723	HGNCID:	7716	Length:	464	Species:	Homo sapiens

Alignment Length:	431	Identity:	232/431 - (53%)
Similarity:	297/431 - (68%)	Gaps:	7/431 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KTKFGPLDDCDRVFQNLYGRHDWRLHGACQRGDWHRTAELLEQGPEWIMKQVSKSGLRGRGGAGF 116
            ||.||.|.|.||:|.||||||||||.|:..||||::|.|:|.:||:||:.::..|||||||||||
Human    29 KTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGF 93

  Fly   117 YAGLKWEFLRQTKSEKVPKMVIVNCAEGEPGTCKDRDILRHEPHKLIEGILLVGVAMGCGRAIVY 181
            ..||||.|:.: .|:..||.::||..||||||||||:||||:||||:||.|:.|.|||...|.:|
Human    94 PTGLKWSFMNK-PSDGRPKYLVVNADEGEPGTCKDREILRHDPHKLLEGCLVGGRAMGARAAYIY 157

  Fly   182 IRNRFYNEACNLHFALAEAYHHGLLGNSVCGTGIKFDVMVQRG-DRYLCGEETAMINCLMGKLGR 245
            ||..|||||.||..|:.|||..||:|.:.||:|..|||.|.|| ..|:||||||:|..:.||.|:
Human   158 IRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGK 222

  Fly   246 PRRRPPFLTEKGYFEHPCLVINAESIAVVPTILRRGSQWWAGLGRSYNTGTKLYCLSGQVNNPCT 310
            ||.:|||..:.|.|..|..|.|.|::||.|||.|||..|:||.||..|:||||:.:||.||:|||
Human   223 PRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCT 287

  Fly   311 VEEEMSIPLKDLIERHAGGVKGGWDNLAAVFPGGLSTPLLDPSTAGKVLMDFDSLTDAGSGFGCG 375
            ||||||:|||:|||:|||||.||||||.||.|||.||||:..|....||||||:|..|.:|.|..
Human   288 VEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTA 352

  Fly   376 AVIVMTKDCDPLAIMLRSIQFFEKHTCKQCSYCRDGAIWLPEIFARFVKGQTHPHEID--WTLVI 438
            |||||.:..|.:..:.|.|:|::..:|.||:.||:|..|:.::.||||:|...|.|||  |.:
Human   353 AVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEI-- 415

  Fly   439 ADKMRNSKPICALAYSQVSVAESLVRMFSRKIEERLLKYAK 479
             .|......||||........:.|:|.|..::|||:.::|:
Human   416 -SKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQ 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-51L2	NP_725449.1	PTZ00304	55..477	CDD:185547	229/424 (54%)
		Complex1_51K	103..275	CDD:279808	97/172 (56%)
		SLBB	298..>335	CDD:287499	27/36 (75%)
		NADH_4Fe-4S	389..466	CDD:287548	27/78 (35%)
NDUFV1	NP_009034.2	PRK13596	35..453	CDD:237441	227/421 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1894
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1523
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D272111at33208
OrthoFinder	1	1.000	-	-		FOG0003103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760