DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-51L2 and ND-51L1

DIOPT Version :9

Sequence 1:	NP_725449.1	Gene:	ND-51L2 / 36695	FlyBaseID:	FBgn0034007	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_611238.2	Gene:	ND-51L1 / 36998	FlyBaseID:	FBgn0034251	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	234/459 - (50%)
Similarity:	296/459 - (64%)	Gaps:	5/459 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TAKKAGGS--KKLGPDRPPIIDPPKGYEPNCKTKFGPLDDCDRVFQNLYGRHDWRLHGACQRGDW 85
            :|...|||  .|.|...||...||....|..||.||||.|.||:|.||||||||||..|.:||||
  Fly   221 SAPPTGGSPPAKSGAPPPPKGPPPGTPPPQTKTTFGPLADADRIFTNLYGRHDWRLKAAMKRGDW 285

  Fly    86 HRTAELLEQGPEWIMKQVSKSGLRGRGGAGFYAGLKWEFLRQTKSEKVPKMVIVNCAEGEPGTCK 150
            ::|.|::.:|.:||:.::..|||||||||||.:||||.|:.:....: ||.::||..||||||||
  Fly   286 YKTKEIIAKGDKWIVNEIKTSGLRGRGGAGFPSGLKWSFMHKPPDGR-PKFLVVNADEGEPGTCK 349

  Fly   151 DRDILRHEPHKLIEGILLVGVAMGCGRAIVYIRNRFYNEACNLHFALAEAYHHGLLGNSVCGTGI 215
            ||:|:||:||||:||.|:.|.|||.....:|||..||||||||.:|:.|||..|.||.:.||:|.
  Fly   350 DREIMRHDPHKLVEGCLIAGRAMGANTGFIYIRGEFYNEACNLQYAIIEAYKAGYLGKNACGSGF 414

  Fly   216 KFDVMVQRG-DRYLCGEETAMINCLMGKLGRPRRRPPFLTEKGYFEHPCLVINAESIAVVPTILR 279
            .||:.|||| ..|:|||||::|..|.||.|:||.:|||..:.|.|..|..|.|.|::||.|||.|
  Fly   415 DFDLYVQRGAGAYICGEETSLIESLEGKAGKPRNKPPFPADIGVFGCPSTVTNVETVAVSPTICR 479

  Fly   280 RGSQWWAGLGRSYNTGTKLYCLSGQVNNPCTVEEEMSIPLKDLIERHAGGVKGGWDNLAAVFPGG 344
            ||..|:|..||:.|:||||:.:||.|.||||||||||:|.::|||||||||.||||||.|:.|||
  Fly   480 RGGNWFASFGRTRNSGTKLFNISGHVCNPCTVEEEMSMPTRELIERHAGGVIGGWDNLLAIIPGG 544

  Fly   345 LSTPLLDPSTAGKVLMDFDSLTDAGSGFGCGAVIVMTKDCDPLAIMLRSIQFFEKHTCKQCSYCR 409
            .|||.:....|...:.|:|.|....|..|.||:|||.||.|.:..:.|...|::..:|.||:.||
  Fly   545 SSTPCITKEHASSAIHDYDGLMAVRSSMGTGALIVMNKDTDIIKAIARLSAFYKHESCGQCTPCR 609

  Fly   410 DGAIWLPEIFARFVKGQTHPHEIDWTLVIADKMRNSKPICALAYSQVSVAESLVRMFSRKIEERL 474
            :|..|:..|..|||.||....|||....:. |......|||||.......:.|:|.|...||||:
  Fly   610 EGLHWVNMIMHRFVTGQAQIAEIDMLFELT-KQIEGHTICALADGAAWPPQGLIRNFRPVIEERI 673

  Fly   475 LKYA 478
            .|.|
  Fly   674 KKRA 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-51L2	NP_725449.1	PTZ00304	55..477	CDD:185547	219/422 (52%)
		Complex1_51K	103..275	CDD:279808	95/172 (55%)
		SLBB	298..>335	CDD:287499	26/36 (72%)
		NADH_4Fe-4S	389..466	CDD:287548	26/76 (34%)
ND-51L1	NP_611238.2	CAP_N	<195..234	CDD:279545	5/12 (42%)
		PRK13596	258..688	CDD:237441	218/422 (52%)
		Complex1_51K	303..472	CDD:279808	93/169 (55%)
		NADH_4Fe-4S	589..670	CDD:287548	27/81 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470258
Domainoid	1	1.000	146	1.000	Domainoid score	I1134
eggNOG	1	0.900	-	-		E1_COG1894
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I71
Isobase	1	0.950	-	0	Normalized mean entropy	S1523
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D272111at33208
OrthoFinder	1	1.000	-	-		FOG0003103
OrthoInspector	1	1.000	-	-		otm51409
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2074
	11	10.850