DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm4b.2

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001269082.1	Gene:	trpm4b.2 / 799647	ZFINID:	ZDB-GENE-061214-2	Length:	1222	Species:	Danio rerio

Alignment Length:	1320	Identity:	370/1320 - (28%)
Similarity:	642/1320 - (48%)	Gaps:	217/1320 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDDT-----KCCCGQAQITHQTIP 153
            :|.:|:.:......|    :..|||.|.|:||.|..|:    :|:     .|.||.|:..|.::
Zfish     1 MNEKDIEEGGVAVMP----KDLSWIPTFFKKRLCTTFV----EDSFSNGGLCQCGAARDHHPSV- 56

  Fly   154 GIESGSPGD--------LWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLF 210
                 :.||        .|..|:|:..|||||||.::| ..:....:.::|||..|.|..:..|.
Zfish    57 -----ALGDNFSTAVVSQWFSTQHSSEQPTDAYGELDF-NNSRKRDSYFLRLSSTTDPAKVFDLM 115

  Fly   211 TKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL- 274
            .:.|.|:.|.|:::|.||:...::::.:...:|:||:|.|::|||||.|||...|:::.:|:|:
Zfish   116 KEHWKLQQPNLVVSVVGGEGRSEVKSWVLDILRQGLVKTAQSTGAWIITGGLRQGISRCIGEAVK 180

  Fly   275 ---LLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDN 336
               .........:|:.|||||||:||....|:......|....:.....   |:|.|..|||||:
Zfish   181 DNATAVSSITLNKVLPIGIAPWGLVENRQHLVNSEGSFPAKVTTQDSCN---LDNNHKAFLLVDD 242

  Fly   337 GTQAKYGAELILRRKLEKFISNLKLHPFTHS-STPVVCLVIEGGTNTIRAVLEYVTDS--PPVPV 398
            ||..:.|.||..|.:||.:||  :..|...| ..||:.::|.|.|    ::||::..|  ...|.
Zfish   243 GTTGRKGGELAFRARLEDYIS--RQRPGNASIDIPVLNMLIAGDT----SMLEFLEMSLKNSTPC 301

  Fly   399 VVCDGSGRAADLLAFVHKY--------ASDGEE-QPVLESMRDYLIGTIQKTFEVGLDQSEKLYQ 454
            :|..|||..|:|::.:.:.        ||:.|: .|::| :|:.|...::|.|... .:::||..
Zfish   302 LVLAGSGGLANLVSDIVENVQSAAMPGASEKEDASPIME-LREQLAAKVKKYFPAE-KKTDKLVD 364

  Fly   455 ELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPE-------QLSLALTWNRVD 512
            ::|...:||::|:::..::  || |::.|..:|..|.::...:..|       :|.||:||||||
Zfish   365 KVLSIYQNKDIISIYNAEQ--EG-AEDFDIVMLKVLVQASKRNVSENTNSYADELRLAVTWNRVD 426

  Fly   513 IARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-- 575
            ||:||:|....:|....|.::|..|||:::..||:||::||:::..:||..|||.|||:....
Zfish   427 IAKSELFNGHIDWKYEELKDSMTDALENNKPQFVRLLIDNGLNISTYLTYNRLEILYNSISDTCL 491

  Fly   576 ANT--LGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYY---------TRRKFRPIYAKV 629
            |.|  |.::...:...|.:.|..:|:::..::..|.|.....:|         |:||
Zfish   492 AKTLLLHHLNERIHQSIKQIYKISLYEVSQLLTDLFGEVCLPFYKAELKLEATTKRK-------- 548

  Fly   630 MNSYANAC---RKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMAL 691
              :..|||   ..|.||:.::                      .:.|:..|.|||||..|::||:
Zfish   549 --ALKNACDVLNGSCTYRDEK----------------------CKHPWLCLFIWAVLQNRREMAI 589

  Fly   692 LMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEK 756
            ..|....|::..:|..|||..    |.::.:::||....::..|.:||...:.:....|:..|..
Zfish   590 FFWEMCGESVLTALAGCKLLL----ELSKQEIETEAKLSMKELALKFEQMAHDVFGTCYQTKASH 650

  Fly   757 AQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP- 820
            :.:||..:...|.:.:||.:|:||:.|...:|...|.:|:.:|.|.:. |....::::|.:..|
Zfish   651 SYKLLIRKSKLWGDATCLKMAIAADARIFFSHDGVQSLLSQIWWGDIE-RGTAFWRLLLVMICPP 714

  Fly   821 -FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVS 884
             .|...::|:..:     |..||:.:        .:..|.|.........||.:|.|....|:
Zfish   715 LCYTNCIEFRKTD-----PAKEEKSM--------TAPPSSPTDSHYEKTVYSFKDIKHQNEGE-- 764

  Fly   885 LTDSDTAQFREFFNLSEYNEVKQH---QPL---RLKKKFY-----EFYTAPITKFWADSIAYMFF 938
              :.|:            |.::|:   :|.   .:|..|.     :|:.||:|.|..:.:.|..|
Zfish   765 --NEDS------------NHIRQNTKGEPAFIESMKSSFVVSRWKQFWYAPVTSFIGNLLMYFLF 815

  Fly   939 LIMFSFTVLVKME----QMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS----VWAWNM 995
            |.::::.:||..:    ..|...|:....::.||..|::||    ..:|...||.    |:|.:|
Zfish   816 LFLYAYVLLVDFKPPPPDGPAVSEYVLYFWVFTLVCEEIRE----ASIAGNKKFPQMLFVYAQDM 876

  Fly   996 WNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVK 1060
            ||..|..||.||:.||..|....:.::||.|.|||.:.:.||:::|..:::.|||.:.::|||:|
Zfish   877 WNKFDVLAISLFITGLCCRMFSWSFNMGRGILCVDYMVFTLRLIHIFAIHRQLGPKIIILGKMIK 941

  Fly  1061 NMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID--------- 1116
            :..:|:..|.|.|.::||:.||:||..........:.|.::||..::|::...:||
Zfish   942 DAFFFLFFLLVWLSAYGVANQALLYQYDPSPARTFRRVLYRPYLHIFGQIPVEEIDTGRHWERDC 1006

  Fly  1117 -----------PPCGEDPSQPGCVTGH-WVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVS 1169
                       .||.:        |.| |:..:.:.::||:.||||:|||||.|:..|::|...|
Zfish  1007 TDNLTLINEGIEPCRD--------TSHNWLVVVLLVIFLLVTNILLVNLLIATFSYTFSKVQERS 1063

  Fly  1170 HQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERL 1234
            ...|.|||:.:::||..:|.|.||||.|.|...|:|..:||.:..:|||   ..|.::..:.:.|
Zfish  1064 DTYWKFQRYNLIVEYHSRPTLAPPFIILSHINLLIKRKIRKVQSAKVQR---FALKIKGQEKKEL 1125

  Fly  1235 YDFEEECVEGFFHEQEIILNQSTD-ERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRK 1298
            ..:|....|.:. ..||...:.|| ||:|..|.:|:::.:           |.|.:::::.|||.
Zfish  1126 VKWENLQKENYL-ALEIKKQRGTDSERLKRITSKVDSVIK-----------QVAEIRDVDRRLRA 1178

  Fly  1299 MEESSEQILSHLAVIHRFMS 1318
            :|...|...|.|..|...:|
Zfish  1179 VESEMEFCTSSLQWIMETLS 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	74/244 (30%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	12/50 (24%)
trpm4b.2	NP_001269082.1	trp	<869..1184	CDD:273311	105/337 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850