DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm2

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	XP_021334453.1	Gene:	trpm2 / 799412	ZFINID:	ZDB-GENE-061214-4	Length:	1513	Species:	Danio rerio

Alignment Length:	1578	Identity:	443/1578 - (28%)
Similarity:	718/1578 - (45%)	Gaps:	289/1578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSP----GDLWLPTKHTRPQPTD 176
            |||:.|.:|:||..::...::.. |.||..::.|..    |:..|    |:.|...:|.|..|||
Zfish    81 SWIKENIKKKECCFYVEDGREGI-CKCGYPKVQHCD----EAIKPEDYMGEQWDKHRHVRETPTD 140

  Fly   177 AYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKE 241
            |:|.|.| ||......:|||:|.||..|.|.||.|::|.|..|.|||:|.||..||.::..||.:
Zfish   141 AFGDISF-GGLGQKTGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKNFYIKTHLKDK 204

  Fly   242 IRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL---LLEGQQRTGRVVSIGIAPWGIVERNHELL 303
            .|:||:|.|:||||||.||||:.||.|.||.|:   .|......|::|.||:||||::.....|:
Zfish   205 FRRGLIKVAQTTGAWILTGGTHAGVMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLI 269

  Fly   304 GHNREVPC-HSISSP-RSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTH 366
            ......|. :|:... :.:|:.|:..|.:|||||:|||..||.|:.||.:|||.||.|.|.....
Zfish   270 HPEGRFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLSLGNRES 334

  Fly   367 SST-PVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESM 430
            ..| ||||:|::||..|:..:...:.:.  .|.||.:||||.||::|.|       ...|| ..:
Zfish   335 GVTIPVVCVVLDGGPGTLNTIYNSMLNH--TPCVVLEGSGRLADVIAHV-------ASVPV-SKV 389

  Fly   431 RDYLIGTIQKTF---------EVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTI 486
            ...||..:.|.|         |:.:.:..|..|::|   |..:|:|||||.   |.:..::|..|
Zfish   390 TMALINRLLKRFFMQEYKNFTELQIIEWTKKIQDIL---RMPHLLTVFRID---EDKNYDVDVAI 448

  Fly   487 LTALFKS----QHLSP---PEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRID 544
            |.||.|:    :|...   ..||.||:.|||||||.||||....:|.:..|..||..||..|:.:
Zfish   449 LQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPE 513

  Fly   545 FVKLLLENGVSMKKFLTIPR-LEELYNTKHGPA---------NTLGYILRDVRPHIPKGYIYTLH 599
            ||:|||||||.:::||.... |.|||:  |.|:         ...|..:|..:..:|......|.
Zfish   514 FVRLLLENGVCVREFLEREETLCELYS--HLPSCFFLRKLAKRVQGGKMRRGQEPLPGSRKVCLS 576

  Fly   600 DIGLVINKLMGGAYRSYYTRRKFRP----IYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGL 660
            .:...:..|:|...:..|...:::|    :..||.:.                 ||..
Zfish   577 HVSEEVRHLLGSFTQPLYIASRYKPTKDDVRLKVPSK-----------------GALD------- 617

  Fly   661 LPFTSEMALFEF-------PFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEA 718
            ||.:.|    |:       |..:|.:|||:...:::|.:.|....:.:|.:|.:.|:.:.:|.|:
Zfish   618 LPCSGE----EWSADTVWDPGRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQES 678

  Fly   719 AEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHR 783
            .||  |:|...|:...|..:|.:...:....:..||::||:||.....||...:||.||:.|:.:
Zfish   679 GED--DSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCLWLALEAHDK 741

  Fly   784 ALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF----YIRQLDFKSKEELQ-QMPQTEEE 843
            :.:||...|.:|..:|.|.|.. .|.::||:  |.|.|    |...|.|:..|::| |..:||::
Zfish   742 SFIAHSGVQALLTQIWCGELSV-DNPHWKVL--LCMIFFPLIYTGFLTFRRDEDIQRQAERTEQQ 803

  Fly   844 HLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQH 908
            .|..:::....||                        ||:.         |.....|:.:|:|
Zfish   804 KLAMESVFAGQSD------------------------GKIK---------RHLRGFSQKSELK-- 833

  Fly   909 QPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKV 973
             ||....:...|..:|..||:.:..:|..||.:|:..:::..:..|.|:|.....::|:|..|::
Zfish   834 -PLNCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEI 897

  Fly   974 REIISS-EPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFR--ENTMDIGRVIYCVDSIYWY 1035
            |::... :......|..::..::||..|..:|:||:.||..|.:  :....||:||.|:|.|.:.
Zfish   898 RQLYHDFDGSGFRRKAKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFYIGKVILCIDFIIFC 962

  Fly  1036 LRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTF 1100
            ||::.|..:::.|||.:.::.:|:.::.:|:.||::.::::||::|.||..|::....:|:...:
Zfish   963 LRLMAIFSISRTLGPKIIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVY 1027

  Fly  1101 QPYFMLYGEVFAGDID------PPC---GEDPSQPGC---------VTGHWVTPITMSMYLLIAN 1147
            :||..::|. |..:||      ..|   ..||.:|.|         |...|:|.:.:.:|||.||
Zfish  1028 EPYITIFGN-FPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTPVFPEWLTIMMLCVYLLFAN 1091

  Fly  1148 ILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAK 1212
            |||:|||||:||..|.||...:..:|.|||:.::.||..:|.||||||.|.|....:       :
Zfish  1092 ILLLNLLIAIFNYTFQEVQDNTDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFI-------R 1149

  Fly  1213 GLEV----QRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQ 1273
            |:.:    ||....:..||:.:.|.|..:|....:.:........:||.:.|:.:|.|:|..||:
Zfish  1150 GVFLRDLPQRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSE 1214

  Fly  1274 KIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEM 1338
            .:|   :::.:.:||:..   ||.::||...:....|..|          .|.|:........:.
Zfish  1215 LLE---REQEMVSATMAK---RLARLEEQVSESAKALRWI----------IDALKSQGCKSKVQP 1263

  Fly  1339 QRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVT----TRRRFNRSLTEVRP 1399
            ..||:.| ||.:.|...|                          |.|    ....|.|.|.  .|
Zfish  1264 PLMRSKS-SDRDDGDSSG--------------------------QETDDEEAPHMFARQLQ--YP 1299

  Fly  1400 DAYIF-----DEGTHFEVVPLPEEP------DEVVKSREALNEQ--------VVRKASMQSEADS 1445
            |:.:.     :|...:||...|.:|      |.......||::.        :..|.::.:...:
Zfish  1300 DSTVRRFPVPEEKVSWEVNFSPYQPPVYNQQDSSESDTSALDKHRNPGGRTGIRGKGALNTLGPN 1364

  Fly  1446 DIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINF 1510
            .|..|:..|....|. |...::.|.:|.                :....|:||....|.......
Zfish  1365 HILHPIFTRWRDAEH-KVLEFLAVWEDA----------------EKRWALLGGPAQPDEPLAQVL 1412

  Fly  1511 EAARHRALRQRTVSLCRRNSETY--------SLTGADINRSHISLNQLASLSRRQMSLTQSEPDS 1567
            |....:.|.::|.:|.:...|.|        :...|.:..|.|:|:                  .
Zfish  1413 ERILGKKLNEKTKTLLKAGEEVYKGYVDDSRNTDNAWVETSIITLH------------------C 1459

  Fly  1568 DKDAPIAQGSAHPGKSVL 1585
            ||:.|:.....|..:|.|
Zfish  1460 DKNTPLMADLNHMVESSL 1477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	73/236 (31%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	13/50 (26%)
trpm2	XP_021334453.1	TRP_2	<734..1138	CDD:331598	126/443 (28%)
trpm2	XP_021334453.1	Nudix_Hydrolase	1345..1467	CDD:320976	25/156 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920