Protein Alignment Trpm and TRPM8

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_011510112.1
• Gene: TRPM8 / 79054
• HGNCID: 17961
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 1259
• Identity: 347/1259 - (27%)
• Similarity: 584/1259 - (46%)
• Gaps: 226/1259 - (17%)

  Fly    70 RGIRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPL--KEHQPRSWIETNFQKRECIKFIP 132
            |..|...|.|:..::.||         |.|..:.:.|..|  .|....::|:.||:||||:.|..
Human     4 RAARLSMRNRRNDTLDST---------RTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTK 59

  Fly   133 CPK-DDTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVR 196
            ..| .:..|.||.||..|.....|   :..:.|...|||:..||||:|.|:|:  ....|.:|:|
Human    60 DSKATENVCKCGYAQSQHMEGTQI---NQSEKWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIR 119

  Fly   197 LSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGG 261
            ||.||..|:|.:|.|:.|:|:.|.|:|:|.||..||.|:.:::| |...|:..|::.||||.|||
Human   120 LSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRK-IFSRLIYIAQSKGAWILTGG 183

  Fly   262 TNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVERNHELLGHNREVPCHSISS------PR 318
            |:.|:.|.:|:.:......|:.  .:|:||||.||:|. |.:.|..|.:...:.::.      .|
Human   184 THYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVS-NRDTLIRNCDAEGYFLAQYLMDDFTR 247

  Fly   319 SKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTH-SSTPVVCLVIEGGTNT 382
            ..|.:|:|.|.:.||||||.......|..||.:|||:||...:....: ...|:||....||..|
Human   248 DPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKET 312

  Fly   383 IRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLD 447
            ::|:...:.:.  :|.||.:|||:.||::|.:.:.........|.|.:..:|..|:.:..|...:
Human   313 LKAINTSIKNK--IPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETE 375

  Fly   448 QSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPE------QLSLAL 506
            ...|..:|:|:|:   :|:||.:::|..:   :.:...|..||:|:...|..:      ||.|.|
Human   376 SWIKWLKEILECS---HLLTVIKMEEAGD---EIVSNAISYALYKAFSTSEQDKDNWNGQLKLLL 434

  Fly   507 TWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNT 571
            .||::|:|..|||...:.|.:..|.|.|..||..||..||:|.||||::::||||...|.||::.
Human   435 EWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSN 499

  Fly   572 KHGPANTLGYILRDVRPHIPKGYIYTLHDIGLV-INKLMGGAYRSYYTRRKFRPIYAKVMNSYAN 635
            ..   :||.|  |:::  |.|.   :.:|..|. :.||:..      .||.||.
Human   500 HF---STLVY--RNLQ--IAKN---SYNDALLTFVWKLVAN------FRRGFRK----------- 537

  Fly   636 ACRKSSTYQYQRYAGANSLSL-VTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEE 699
                      :...|.:.:.: :..:.|.|      ..|...|.|||:|..:::::.::|.....
Human   538 ----------EDRNGRDEMDIELHDVSPIT------RHPLQALFIWAILQNKKELSKVIWEQTRG 586

  Fly   700 ALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCE 764
            ....:|.:.||.|.:|  ..::|::..  .|....|.|:|::..:|....|..|.:.|::||...
Human   587 CTLAALGASKLLKTLA--KVKNDINAA--GESEELANEYETRAVELFTECYSSDEDLAEQLLVYS 647

  Fly   765 LHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFK 829
            ..:|...:||.|||.|..:..:|.|..|..|:..|.|.: :|...|:|:||.|.:
Human   648 CEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFI---------- 701

  Fly   830 SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFR 894
                                                                 :.|.......||
Human   702 -----------------------------------------------------IPLVGCGFVSFR 713

  Fly   895 EFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQE- 958
            :       ..|.:|:  :|...:..|:|:|...|..:.:.|:.||::|::.:|:....:|...|
Human   714 K-------KPVDKHK--KLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPEL 769

  Fly   959 -WYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWN-------MWNPCDGAAIILFVIGLAFRF 1015
             .||:.::  |..::||:               |..|       :||..|...:..|:.|:.||.
Human   770 VLYSLVFV--LFCDEVRQ---------------WYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRL 817

  Fly  1016 ---RENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFG 1077
               .::::..||||:|:|.|.:.||:::|..|::.|||.:.|:.:|:.::.:|:.|.||.:::||
Human   818 HSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFG 882

  Fly  1078 VSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGE--------DPSQPGCVT---- 1130
            |:||.||..|:|....:.:.|.::||..::|:| ..|:|....:        :.|:|.||.
Human   883 VARQGILRQNEQRWRWIFRSVIYEPYLAMFGQV-PSDVDGTTYDFAHCTFTGNESKPLCVELDEH 946

  Fly  1131 -----GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVL 1190
                 ..|:|...:.:|:|..||||:|||:|:|......|...:.|||.|||:.:|.||..:..:
Human   947 NLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNI 1011

  Fly  1191 PPPFIALCHFYSLLKYCVR---KAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEII 1252
            |.|||...:||.::|.|.:   |.|.:|    :.:..|..:|:       |....||...|..::
Human  1012 PFPFIVFAYFYMVVKKCFKCCCKEKNME----SSVCCFKNEDN-------ETLAWEGVMKENYLV 1065

  Fly  1253 -LNQSTDERVKNTTERVETMSQKI 1275
             :|...::..:....|...:..||
Human  1066 KINTKANDTSEEMRHRFRQLDTKI 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	70/244 (29%)
		TRPM_tetra	1262..1313	CDD:293127	3/14 (21%)
TRPM8	XP_011510112.1	Ion_trans	756..989	CDD:278921	71/250 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146034
Domainoid	1	1.000	51	1.000	Domainoid score	I11605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850